Patents by Inventor Dexue Sun

Dexue Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGULATED BIOCIRCUIT SYSTEMS
    Publication number: 20230233608
    Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Application
    Filed: August 16, 2022
    Publication date: July 27, 2023
    Applicant: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Peter Barrett, Michael N. Gladstone, Tariq A. Kassum, Vipin Suri, Dan Jun Li, Dexue Sun, Brian Dolinski
  • PDE5 compositions and methods for immunotherapy
    Patent number: 11666642
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Grant
    Filed: February 1, 2022
    Date of Patent: June 6, 2023
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • DHFR tunable protein regulation
    Patent number: 11629340
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Grant
    Filed: September 2, 2019
    Date of Patent: April 18, 2023
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Dan Jun Li, Dexue Sun, Byron Delabarre, Vijaya Balakrishnan, Brian Dolinski, Mara Christine Inniss, Grace Y. Olinger
  • TANDEM CD19 CAR-BASED COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20230092895
    Abstract: The present invention provides biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: August 30, 2019
    Publication date: March 23, 2023
    Inventors: Vipin Suri, Michael Joseph Briskin, Brian Dolinski, Kutlu Goksu Elpek, Tucker Ezell, Scott Francis Heller, Mara Christine Inniss, Tariq A. Kassum, Nicole Kosmider, Abhishek Kulkarni, Meghan Langley, Dan Jun Li, Michelle Lynn Ols, Benjamin J. Primack, Celeste Richardson, Steven Mark Shamah, James Storer, Dexue Sun, Vijaya Balakrishnan, Andrew R.M. Bradbury, Michael Frank Erasmus, Fortunato Ferrara
  • PDE5 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20230074330
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: February 1, 2022
    Publication date: March 9, 2023
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • CA2 COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20230026259
    Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities. In particular, the present application is directed to fusion proteins comprising a fragment of human human carbonic anhydrase 2 and a chimeric antigen receptor (CAR). The activity of the destabilizing domain can be regulated by externally administered agents.
    Type: Application
    Filed: March 6, 2020
    Publication date: January 26, 2023
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Celeste RICHARDSON, Brian DOLINSKI, Abhishek KULKARNI, Mara Christine Inniss, Dexue SUN, Elizabeth Jane WEISMAN, Grace Y. Olinger, Scott Francis HELLER, Jennifer Leah GORI, Michelle Lynn OLS, Kutlu Goksu ELPEK, Tucker Read EZELL, Michael SCHEBESTA, Michelle Lois FLEURY, Dhruv Kam SETHI
  • PDE5 DERIVED REGULATORY CONSTRUCTS AND METHODS OF USE IN IMMUNOTHERAPY
    Publication number: 20220403001
    Abstract: The present disclosure relates to tunable biocircuit systems for the development of controlled and/or regulated therapeutic systems. In particular, regulatable biocircuits containing destabilizing domains (DD) derived from mutant human cGMP-specific phosphodiesterase type 5 (PDE5) are disclosed. Especially, the present disclosure provides an effector module. Such effector module may include (a) a stimulus response element (SRE), wherein the SRE is a DD, said DD comprising at least one mutation relative to cGMP-specific 3?,5?-cyclic phosphodiesterase (hPDE5; SEQ ID NO: 1) and (b) at least one payload, which is attached, appended or associated with said SRE. The SRE may be responsive to one or more stimuli.
    Type: Application
    Filed: June 12, 2019
    Publication date: December 22, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Celeste RICHARDSON, Brian DOLINSKI, Abhishek KULKARNI, Mara Christine INNISS, Dexue SUN, Dan Jun LI, Grace Y. OLINGER, Scott Francis HELLER, Jennifer Leah GORI, Byron DELABARRE
  • CA2-IL15 FUSION PROTEINS FOR TUNABLE REGULATION
    Publication number: 20220332780
    Abstract: The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (EL15) payloads, as well as compositions and methods of use thereof.
    Type: Application
    Filed: September 10, 2020
    Publication date: October 20, 2022
    Inventors: Kutlu Goksu ELPEK, Dhruv Kam SETHI, Meghan C. LANGLEY, Tucker Read EZELL, Dexue SUN, Jennifer Leah GORI, Geetha Hanna MYLVAGANAM, Michelle OLS, Michelle FLEURY, Celeste RICHARDSON, James A. STORER, Vipin SURI, Shyamsundar SUBRAMANIAN, Colleen FOLEY, Molly Reed PERKINS, Jeremy Hatem TCHAICHA, Scott Francis HELLER
  • Regulated biocircuit systems
    Patent number: 11446398
    Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: September 20, 2022
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Peter Barrett, Michael N. Gladstone, Tariq A. Kassum, Vipin Suri, Dan Jun Li, Dexue Sun, Brian Dolinski
  • CA2 COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20220267398
    Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Application
    Filed: June 12, 2020
    Publication date: August 25, 2022
    Inventors: Michelle Lynn OLS, Vipin SURI, Dexue SUN, Dhruv Kam SETHI, Michael SCHEBESTA, Michelle Lois FLEURY, Kutlu Goksu ELPEK
  • DHFR TUNABLE PROTEIN REGULATION
    Publication number: 20220213449
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: December 28, 2021
    Publication date: July 7, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Dan Jun LI, Dexue SUN, Byron DELABARRE, Vijaya BALAKRISHNAN, Brian DOLINSKI, Mara Christine INNISS, Grace Y. OLINGER
  • CD40L COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20220175781
    Abstract: The present disclosure provides regulatable biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: March 6, 2020
    Publication date: June 9, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Michael SCHEBESTA, Michelle Lois FLEURY, Kutlu Goksu ELPEK, Elizabeth Jane WEISMAN, Vipin SURI, Dexue SUN, Dan Jun LI, Steven Mark SHAMAH, Michael Joseph BRISKIN, Celeste RICHARDSON, Tariq A. KASSUM, Michelle Lynn OLS, Brian DOLINSKI, Mara Christine INNISS, Emily BRIDEAU, Jennifer Leah GORI, Dhruv Kam SETHI
  • MEMBRANE BOUND IL12 COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20220056092
    Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Application
    Filed: December 11, 2019
    Publication date: February 24, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Michelle Lynn OLS, Vipin SURI, Dexue SUN, Dan Jun LI, Dhruv Kam SETHI, Abhishek KULKARNI, Benjamin J. PRIMACK, James STORER
  • PDE5 compositions and methods for immunotherapy
    Patent number: 11241485
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: February 8, 2022
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • ER TUNABLE PROTEIN REGULATION
    Publication number: 20210386788
    Abstract: The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: October 23, 2019
    Publication date: December 16, 2021
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Dexue SUN, Michelle Lynn OLS, Scott Francis HELLER, Dan Jun LI, Celeste RICHARDSON, Mara Christine INNISS, Jennifer Leah GORI, Benjamin J. PRIMACK, Abhishek KULKARNI, Brian DOLINSKI, Tucker Read EZELL, Michael SCHEBESTA, James A. STORER, Kutlu Goksu ELPEK
  • CA2 compositions and methods for tunable regulation
    Patent number: 11058725
    Abstract: The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: July 13, 2021
    Assignee: Obsidian Therapeutics, Inc.
    Inventors: Kutlu Goksu Elpek, Dhruv Kam Sethi, Meghan C. Langley, Tucker Read Ezell, Dexue Sun, Jennifer Leah Gori, Geetha Hanna Mylvaganam, Michelle Ols, Michelle Fleury, Celeste Richardson, James A. Storer, Vipin Suri, Shyamsundar Subramanian, Colleen Foley, Molly Reed Perkins, Jeremy Hatem Tchaicha, Scott Francis Heller
  • CA2 COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20210069248
    Abstract: The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.
    Type: Application
    Filed: September 10, 2020
    Publication date: March 11, 2021
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Kutlu Goksu ELPEK, Meghan C. LANGLEY, Tucker Read EZELL, Dexue SUN, Jennifer Leah GORI, Geetha Hanna MYLVAGANAM, Michelle OLS, Michelle FLEURY, Celeste RICHARDSON, James A. STORER, Vipin SURI, Shyamsundar SUBRAMANIAN, Colleen FOLEY, Molly Reed PERKINS, Jeremy Hatem TCHAICHA, Scott Francis HELLER
  • DHFR TUNABLE PROTEIN REGULATION
    Publication number: 20200172879
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: September 2, 2019
    Publication date: June 4, 2020
    Inventors: Vipin SURI, Dan Jun LI, Dexue SUN, Byron DELABARRE, Vijaya BALAKRISHNAN, Brian DOLINSKI, Mara Christine INNISS, Grace Y. OLINGER
  • PDE5 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20200101142
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: June 12, 2018
    Publication date: April 2, 2020
    Inventors: Vipin SURI, Byron DELABARRE, Michael N. GLADSTONE, Celeste RICHARDSON, Brian DOLINSKI, Abhishek KULKARNI, Mara Christine INNISS, Dexue SUN, Dan Jun LI, Grace Y. OLINGER, Scott Francis HELLER
  • REGULATED BIOCIRCUIT SYSTEMS
    Publication number: 20190192691
    Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Application
    Filed: April 11, 2017
    Publication date: June 27, 2019
    Inventors: Peter Barrett, Michael N. Gladstone, Tariq A. Kassum, Vipin Suri, Dan Jun Li, Dexue Sun, Brian Dolinski