Patents by Inventor Deyan Luo

Deyan Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nicotinic acid or isonicotinic acid compound and use thereof
    Patent number: 10981873
    Abstract: Disclosed are a nicotinic acid or isonicotinic acid compound and a use thereof. The compound is the compound shown in Formula I, or a pharmaceutically acceptable salt, ester or solvate thereof. Efficacy tests demonstrate that the nicotinic acid compound can inhibit botulinum toxin endopeptidase activity in vitro, and has a significant protective effect on mice poisoned with botulinum toxin. On this basis, the compound may be used to prepare a drug preventing and/or treating botulinum toxin exposure and/or poisoning.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: April 20, 2021
    Assignee: ACADEMY OF MILITARY MEDICAL SCIENCES
    Inventors: Hui Wang, Tao Li, Zhenyuan Miao, Jianxin Wang, Deyan Luo, Jie Huang, Chunlin Zhuang, Yuelin Wu
  • NICOTINIC ACID OR ISONICOTINIC ACID COMPOUND AND USE THEREOF
    Publication number: 20190241522
    Abstract: Disclosed are a nicotinic acid or isonicotinic acid compound and a use thereof. The compound is the compound shown in Formula I, or a pharmaceutically acceptable salt, ester or solvate thereof. Efficacy tests demonstrate that the nicotinic acid compound can inhibit botulinum toxin endopeptidase activity in vitro, and has a significant protective effect on mice poisoned with botulinum toxin. On this basis, the compound may be used to prepare a drug preventing and/or treating botulinum toxin exposure and/or poisoning.
    Type: Application
    Filed: September 8, 2017
    Publication date: August 8, 2019
    Applicant: Academy of Military Medical Sciences
    Inventors: Hui WANG, Tao LI, Zhenyuan MIAO, Jianxin WANG, Deyan LUO, Jie HUANG, Chunlin ZHUANG, Yuelin WU
  • Luteolin and diosmin/diosmetin as novel STAT3 inhibitors for treating autism
    Patent number: 8778894
    Abstract: The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: July 15, 2014
    Assignee: University of South Florida
    Inventors: Jun Tan, Deyan Luo, Roland Douglas Shytle
  • LUTEOLIN AND DIOSMIN/DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TREATING AUTISM
    Publication number: 20140038913
    Abstract: The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.
    Type: Application
    Filed: October 4, 2013
    Publication date: February 6, 2014
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jun Tan, Deyan Luo
  • LUTEOLIN AND DIOSMIN/DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TREATING AUTISM
    Publication number: 20110201565
    Abstract: The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 18, 2011
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jun Tan, Deyan Luo