Abstract: The present disclosure provides a ketone carbonyl-containing hydrophobic antitumor drug and a conjugate thereof as well as a nano preparation containing the conjugate, a preparation method therefor, and an application thereof. The conjugate is an amphipathic pH-responsive conjugate obtained by enabling a dehydration condensation reaction between a hydrazide-terminated polyethylene glycol and/or lactose hydrazide and the ketone carbonyl-introduced hydrophobic antitumor drug. The ketone carbonyl-introduced hydrophobic antitumor drug is obtained by reacting an isocyanate group in a compound containing isocyanate group and ketone carbonyl group with a hydroxyl on a hydroxyl-containing hydrophobic antitumor drug. The hydroxyl-containing hydrophobic antitumor drug includes at least one of paclitaxel, docetaxel, paclitaxel derivatives, or docetaxel derivatives.

Abstract: A conjugate for active targeted therapy of tumors is obtained by coupling a hydrophilic affibody with an active tumor targeting function and a hydrophobic anti-tumor cytotoxin through a small molecule linker. The affibody has a specific binding activity and a high affinity to receptors overexpressed on surfaces of various tumor cells. The cytotoxin is a highly effective anti-tumor drug. The affibody-cytotoxin conjugate can self-assemble in water to form the nanoparticle with the affinity body as a shell and the cytotoxin as an inner core. Since the affibody can specifically recognize and bind to receptors overexpressed on the surfaces of the tumor cells, the nanoparticle can be efficiently enriched at tumor sites and biodegraded through the linker to release the cytotoxin and reach effective therapeutic concentrations for inhibiting the growth of the tumors while reducing toxic and side effects to normal organs and tissues.

Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Abstract: The present disclosure provides a ketone carbonyl-containing hydrophobic antitumor drug and a conjugate thereof as well as a nano preparation containing the conjugate, a preparation method therefor, and an application thereof. The conjugate is an amphipathic pH-responsive conjugate obtained by enabling a dehydration condensation reaction between a hydrazide-terminated polyethylene glycol and/or lactose hydrazide and the ketone carbonyl-introduced hydrophobic antitumor drug. The ketone carbonyl-introduced hydrophobic antitumor drug is obtained by reacting an isocyanate group in a compound containing isocyanate group and ketone carbonyl group with a hydroxyl on a hydroxyl-containing hydrophobic antitumor drug. The hydroxyl-containing hydrophobic antitumor drug includes at least one of paclitaxel, docetaxel, paclitaxel derivatives, or docetaxel derivatives.

Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Abstract: The reaction product of a monomer comprising phthalazinone and a phenol group, and at least one sulfonated aromatic compound. The monomer comprising phthalazinone and a phenol group is used in a reaction with the sulfonated aromatic compound to produce ionomers with surprising and highly desirable properties. In one embodiment, the inventive ionomer is a sulfonated poly(phthalazinone ether ketone), hereinafter referred to as sPPEK. In another embodiment, the inventive ionomer is a sulfonated poly(phthalazinone either sulfone), herein after referred to as SPPES. In another embodiment, the inventive ionomer is other sulfonated aromatic polymeric compounds. The invention further includes the formation of these polymers into membranes and their use for polymer electrolyte membrane fuel cells (PEMFC), and in particular for direct methanol fuel cells (DMFC).

Abstract: The reaction product of a monomer comprising phthalazinone and a phenol group, and at least one sulfonated aromatic compound. The monomer comprising phthalazinone and a phenol group is used in a reaction with the sulfonated aromatic compound to produce ionomers with surprising and highly desirable properties. In one embodiment, the inventive ionomer is a sulfonated poly(phthalazinone ether ketone), hereinafter referred to as sPPEK. In another embodiment, the inventive ionomer is a sulfonated poly(phthalazinone either sulfone), herein after referred to as SPPES. In another embodiment, the inventive ionomer is other sulfonated aromatic polymeric compounds. The invention further includes the formation of these polymers into membranes and their use for polymer electrolyte membrane fuel cells (PEMFC), and in particular for direct methanol fuel cells (DMFC).