Patents by Inventor Dezso Korbonits
Dezso Korbonits has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6348470Abstract: The invention relates to the use of theobromine and/or its salts and/or its complexes optionally in admixture with other known active ingredients and inert solid or liquid carriers, additives and auxiliary agents for the manufacture of a pharmaceutical composition suitable for relieving cough syndrome. Further subject of the invention is a method of treatment of a human or animal subject being in condition where relieving of cough is desirable which comprise steps of administering in an effective amount theobromine and/or salts and/or its complexes optionally in admixture with other known active ingredients and suitable inert, solid or liquid carriers, additives and auxiliary agents.Type: GrantFiled: September 24, 1999Date of Patent: February 19, 2002Inventors: Dezsö Korbonits, Péter Arányi, István Jelinek, Endre Mikus
-
Patent number: 5648498Abstract: A process is described for the preparation of 4-Methyl-5-(2-Chloroalkyl)-thiazole wherein the alkyl ranges from C.sub.2 -C.sub.5, by providing the steps of either a) converting the 3-thiocyanato-5-chloro-2-alkanone into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole by gaseous hydrochloric acid in an organic solvent and hydrogenating the compound in the presence of a metal catalyst in an organic solvent, or b) reacting 3-thiocyanato-5-choro-2-alkanone with aqueous mineral acid and treating the thiazole obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole in an organic solvent in presence of a metal catalyst.Type: GrantFiled: June 27, 1994Date of Patent: July 15, 1997Assignee: Astra AktiebolagInventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szvoboda nee Kanzel, Gergely Heja, Pal Kiss, Csaba Gonczi, Ferenc Sperber, Csaba Huszar, Gyorgy Mihalovics, Attila Nemeth, Mihaly Sut, Karol Gyure, Istvan Bone, Ferenc Morasz, Laszlo Ledniczky, Erzsebet Szabo nee Kardos, Peter Gyri, Erzsebet Szalay, Karoly Ban, Ildiko Buttkai, Arpad Kvari, Sandor Garaczy
-
Patent number: 5534644Abstract: The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.Type: GrantFiled: June 5, 1995Date of Patent: July 9, 1996Assignee: Aktiebolaget AstraInventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szvoboda nee Kanzel, Gergely Heja, Pal Kiss, Csaba Gonczi, Ferenc Sperber, Csaba Huszar, Gyorgy Mihalovics, Attila Nemeth, Mihaly Su, Karol Gyure, Istvan Bone, Ferenc Morasz, Laszlo Ledniczky, Erzsebet Szabo nee Kardos, Peter Gy ri, Erzsebet Szalay, Karoly Ban, Iidiko Buttkai, Arpad K vari, Sandor Garaczy
-
Patent number: 4988730Abstract: The invention relates to novel diphenylpropylamine derivatives of the general formula (I). ##STR1## R.sup.1 stands for hydrogen or a methyl group; R.sup.2 stands for hydrogen, a methyl or n-decyl group;Z means a phenyl group substituted by R.sup.3, R.sup.4 and R.sup.5, whereinR.sup.3 means hydrogen, fluorine, chlorine or bromine, or a nitro, C.sub.1-12 alkyl, C.sub.1-4 alkoxy, phenoxy or benzyloxy group;R.sup.4 and R.sup.5 represent hydrogen, chlorine or a hydroxy, alkoxy, benzyloxy, acetamino or carboxy group; orR.sup.4 and R.sup.5 together form a methylendioxy group;orZ may stand for a 4-methoxynaphtyl or 4-ethoxy-naphthyl group; andR.sup.6 stands for hydrogen or fluorine, with the proviso that each of R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 cannot simultaneously stand for hydrogen, as well as their physiologically acceptable acid addition salts.The invention also relates to a process for the preparation of these compounds and to the pharmaceutical compositions containing these compounds.Type: GrantFiled: July 21, 1989Date of Patent: January 29, 1991Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyar RTInventors: Dezso Korbonits, Pal Kiss, Laszlo Szekeres, Gyula Papp, Gabor Kovacs, Andrea Santane Csutor, Sandor Virag, Eva Udvari, Imre Bata, Katalin Marmarosi nee Kellner, Laszlo Tardos, Peter Kormoczy, Vera Gergely, Zoltan Vargai
-
Patent number: 4960773Abstract: The present invention relates to new compounds of Formula I ##STR1## and physiologically acceptable salts thereof wherein A and B stand for oxygen or --CH.sub.2 group with the proviso that if A stands for oxygen, then B stands for --CH.sub.2 group and R stands for hydrogen and, if A represents a --CH.sub.2 group, then B stands for oxygen, R stands for a --CH.sub.2 Q group wherein Q stands for hydrogen, and pyrrolidino, piperidino or morpholino and a process for the preparation thereof and pharmaceutical compositions containing as active ingredient a compound of the Formula (I) or a physiologically acceptable salt thereof.Type: GrantFiled: November 2, 1988Date of Patent: October 2, 1990Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara RT.Inventors: Dezso Korbonits, Gergely Heja, Maria Szomor, Emil Minker
-
Patent number: 4940716Abstract: Diuretic and saluretic tetrahydro-isoquinoline derivatives of the Formula (I) ##STR1## wherein R stands for hydrogen or chlorine,R.sup.1 and R.sup.2 are hydrogen, methoxy or ethoxy, andR.sup.3 and R.sup.4 are hydrogen or methyl,and a process for the preparation thereof as well as pharmaceutical compositions containing as active ingredients isoquinoline derivatives of the Formula (I). The compounds of Formula I are prepared by reacting a 2-amino-tetrahydro-isoquinoline derivative of the Formula (II) ##STR2## with a carboxylic acid derivative of the Formula (III) ##STR3## wherein x stands for chlorine, --OH, --OCH.sub.2 CN, --OCH.sub.3, --OC.sub.2 H.sub.5, --OCOOCH.sub.3 or --OCOOC.sub.2 H.sub.5R.sup.5 and R.sup.6 stand for hydrogen or together from CHN(CH.sub.3).sub.2 and in case of the Formula (Ia) ##STR4## splitting off the protective group in alkaline medium.Type: GrantFiled: December 29, 1988Date of Patent: July 10, 1990Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szyoboda nee Kanzel, Laszlo Harsing, Gyorgy Simon, Vera Gergely, Peter Kormoczi, Katalin Marmarosi nee Keliner, Sandor Virag
-
Patent number: 4916149Abstract: The present invention relates to novel compounds of the general formula ##STR1## wherein R is hydrogen atom or a trifluoromethyl, carboxy, C.sub.2-5 alkoxycarbonyl, cyano, benzoyl, sulfamoyl or C.sub.1-4 alkylsulfonyl group;R.sup.1 is hydrogen atom or a linear or branched chain C.sub.1-4 alkyl, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulfonyl, benzylthio, benzylsulfonyl, phenyl, hydroxy or mercapto group; andR.sup.2 is hydrogen or chlorine atom,as well as their pharmaceutically acceptable salts.The compounds according to the invention possess diuretic and saluretic activity with an advantageous Na/K ratio.Type: GrantFiled: December 29, 1988Date of Patent: April 10, 1990Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szoboda nee Kanzel, Laszlo Harsing, Gyorgy Simon, Sandor Virag, Vera Gergely, Katalin Marmarosi nee Kellner
-
Patent number: 4840949Abstract: The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I ##STR1## and pharmaceutically acceptable salts thereof wherein A stands for C.sub.1-4 alkylene andR.sup.1 represents C.sub.1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C.sub.5-6 cycloalkyl or aminoalkyl of the Formula --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 in which group n is an integer 1-3; R.sup.2 and R.sup.3 each stand for hydrogen or C.sub.1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; orR.sup.1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzylThe compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.Type: GrantFiled: October 9, 1987Date of Patent: June 20, 1989Assignee: Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.Inventors: Dezso Korbonits, Emil Minker, Zoltan Vargai, Gergely Heja, Gabor Kovacs, Agnes Gottsegen, Sandor Antus, Sandor Virag, Andrea Bolehovszky, Jeno Marton, Katalin Marmarosi nee Kellner, Lorand Debreczeni, Laszlo Tardos, Peter Kormoczy, Vera Gergely, Gabor Horvath
-
Patent number: 4709081Abstract: The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, whereinR.sup.2 stands for a straight or branched chained alkyl having 1 to 8 carbon atoms optionally substituted with phenyl, naphthyl, tetrahydronaphthyl or m-phenoxy-benzyl, cycloalkyl having 3 to 6 carbon atoms optionally substituted with one or more straight or branched chained alkyl or alkenyl having 1 to 6 carbon atoms, phenyl or naphthyl.The compounds of formula (I) are prepared according to the invention by(a) reacting esters of formula (II) ##STR2## wherein X stands for chlorine or bromine andR.sup.2 has the same meanings as defined above with a phenol alkali metal salt and(b) if desired converting the diphenyl ethers so obtained to a specific compound of formula (I), m-phenoxybenzyl alcohol by the hydrolysis of the ester group.Type: GrantFiled: September 26, 1985Date of Patent: November 24, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Gergely Heja, Dezso Korbonits, Endre Palosi, Pal Kiss, Csaba Gonczi, Ida Szvoboda nee Kanzel, Ede Marvanyos, Judit Kun, Maria Szomor nee Wundele, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky
-
Patent number: 4599327Abstract: 2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R.sup.2' stands for C.sub.1 to C.sub.12 alkyl or a group of the formula ##STR2## in which R.sup.11 is C.sub.1 to C.sub.4 alkyl;R.sup.12 is hydrogen or C.sub.1 to C.sub.4 alkyl;n is 0 or 1;p is 1 to 4;r is 1 to 4; andR.sup.3' and R.sup.4' are each C.sub.1 to C.sub.4 alkyl, or pharmaceutically salts thereof are disclosed, having analgesic activity.Type: GrantFiled: December 2, 1983Date of Patent: July 8, 1986Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Mihaly Nogradi, Dezso Korbonits, Agnes Gottsegen, Sandor Antus, Zsuzsa Furst, Jozsef Knoll, Jozsef Szejtli, Agnes Stadler, Gabor Kovacs, Katalin Marmarosi
-
Patent number: 4599428Abstract: A process is disclosed for the preparation of a compound of the formula (XI) ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.3 alkoxy, or trifluoromethyl;R.sup.5 is amino or C.sub.1 to C.sub.4 alkoxycarbonylamino; andR.sup.4" is C.sub.1 to C.sub.6 alkyl, C.sub.2 to C.sub.6 alkenyl, C.sub.2 to C.sub.6 alkynyl, cyclohexyl, benzyl, or 2-phenyl-ethyl, which comprises the steps of:(a) reacting a compound of the formula (VIII) ##STR2## or a salt thereof, with a basic nucleophilic compound to yield a salt of the formula (IX) ##STR3## wherein R.sup.4' is a lone pair of electrons, in which case an alkali metal or alkali earth metal cation forms a salt with the sulfur atom; and(b) reacting a salt of the formula (IX) with a compound of the formula (X)R.sup.4' --QwhereinQ is hydroxyl, halogen, 1/2SO.sub.4, 1/3PO.sub.3, SO.sub.3 C.sub.6 H.sub.5, or SO.sub.3 C.sub.6 H.sub.4 CH.sub.3 to yield the desired product.Type: GrantFiled: March 21, 1984Date of Patent: July 8, 1986Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Csaba Gonczi, Dezso Korbonits, Endre Palosi, Pal Kiss, Gergely Heja, Judit Kun, Maria Szomor nee Wundele, Ida Szvoboda nee Kanzel, Ede Marvanyos, Karoly Horvath, Vera Kovacs nee Mindler, Livia Nagy nee Koranyi
-
Patent number: 4565817Abstract: Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,R.sub.2 stands for hydrogen or straight or branched chain alkyl,R.sub.3 stands for hydrogen or straight or branched chain alkyl or,R.sub.2 and R.sub.3 together with the nitrogen atom may form a 5-6 membered ring, which ring can optionally contain an oxygen or a second nitrogen atom, the latter, optionally substituted by methyl or,R.sub.1 can stand for a phenyl group of the formulaR.sub.4 R.sub.5 C.sub.6 H.sub.3whereinR.sub.4 and R.sub.5 represent independently hydrogen, chlorine, hydroxy, methoxy, ethoxy, methyl or amino or,R.sub.Type: GrantFiled: March 11, 1983Date of Patent: January 21, 1986Assignee: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara R.T.Inventors: Dezso Korbonits, Maria Szomor nee Wundele, Gergely Heja, Ida Szvoboda nee Kanzel, Pal Kiss, Csaba Gonczi, Endre Palosi, Gabor Kovacs, Judit Kun, Emil Minker, Sandor Virag, Gyula Sebestyen, Tamas Szuts
-
Patent number: 4518588Abstract: An inclusion complex is disclosed of N-(1-phenylethyl)-3, 3-diphenyl-propylamine or its hydrochloride complexed with a cyclodextrin as well as a process for the preparation thereof and pharmaceutical compositions containing same. The new inclusion complexes have coronary dilatory activity and have greater water soluble than simple N-(1-phenylethyl)-3, 3-diphenyl-propyl amine or the hydrochloride thereof.Type: GrantFiled: December 22, 1982Date of Patent: May 21, 1985Assignee: CHINOIN Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Jozsef Szejtli, Agnes Stadler nee Szoke, Maria Vikmon nee Kiraly, Dezso Korbonits, Sandor Virag, Istvan Turcsan, Pal Kiss
-
Patent number: 4473697Abstract: A new process is disclosed for the preparation of a compound of the formula (VIII) ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, or trifluoromethyl;R.sup.5 is amino or C.sub.1-4 alkoxycarbonylamino; or a salt thereof, which comprises reacting a compound of the formula (II) ##STR2## with gaseous chlorine and a rhodanide of the formula (III)R--SCN (III)wherein R represents a metal ion or ammonium.Type: GrantFiled: January 17, 1983Date of Patent: September 25, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Csaba Gonczi, Dezso Korbonits, Endre Palosi, Pal Kiss, Gergely Heja, Judit Kun, Maria Szomor nee Wundele, Ida Szvoboda nee Kanzel, Ede Marvanyos, Karoly Horvath, Vera Kovacs nee Mindler, Livia Nagy nee Koranyi
-
Patent number: 4465855Abstract: Arylacetic acid derivatives of the formula ##STR1## with R.sup.1, R.sup.2 and R.sup.3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are prepared by catalytic hydrogenation of new compounds of the formula ##STR2## in which R and R.sup.10 are also specifically defined. The method of making the latter compound is also set forth.Type: GrantFiled: April 15, 1982Date of Patent: August 14, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Endre Palosi, Dezso Korbonits, Pal Kiss, Csaba Gonczy, Gergely Heja, Judit Cser nee Kun, Rudolf Szebeni, Maria Szomor nee Wundele, Ida Szvoboda nee Kanzel
-
Patent number: 4393008Abstract: 2-(3-phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.Type: GrantFiled: August 12, 1981Date of Patent: July 12, 1983Assignee: Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara RtInventors: Endre Palosi, Gergely Heja, Dezso Korbonits, Pal Kiss, Csaba Gunczi, Judit Cser, Ida Szvoboda, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky, Maria Szomor
-
Patent number: 4391821Abstract: The present invention relates to novel 7-substituted benzopyranes of formula (I), whereinR.sub.1 and R.sub.2 are hydrogen, alkyl of from 1 to 6 carbon atoms, hydroxyalkyl, alkenyl, cycloalkyl, phenylalkyl, dimethoxy-phenylalkyl, or R.sub.1 and R.sub.2 together with the joining nitrogen atom may represent a 5-7-membered heterocyclic ring,R.sub.3 is hydrogen, alkyl of from 1 to 4 carbon atoms or phenyl,R.sub.4 is hydrogen,R.sub.5 is hydrogen or phenyl, orR.sub.4 and R.sub.5 together may represent a bonding electron pair between the second and the third carbon atoms of the benzopyrane ring,R.sub.6 and R.sub.7 are hydrogen or they may represent an oxygen atom together,n is 1 or 2,with the proviso, that the pyrane ring may bear only one alkyl or phenyl substituent, and preparation process thereof.The novel compounds have valuable therapeutical effects, mainly in cardiotherapy.Type: GrantFiled: July 17, 1981Date of Patent: July 5, 1983Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Dezso Korbonits, Mihaly Nogradi, Borbala Vermes nee Szluha, Janos Strelisky, Andras Wolfner, Gergely Heja, Gabor Kovacz, Jozsef Szegi, Sandor Virag
-
Patent number: 4385004Abstract: New compounds of the formula (VIIIa) are disclosed ##STR1## wherein R.sup.1 is hydrogen, methyl or ethyl;R.sup.2 is hydrogen, fluoro, or alkyl having 1 to 4 carbon atoms;R.sup.3 is hydrogen, phenyl, alkoxy having 1 to 6 carbon atoms; phenoxy, thenoyl, or benzoyl; orR.sup.2 and R.sup.3 together with the phenyl group to which they are attached form a naphthyl group which is unsubstituted or substituted by C.sub.1 to C.sub.4 alkyl or C.sub.1 to C.sub.4 alkoxy;R.sup.10 is phenylaminocarbonyl, 1-phenyl-5-tetrazolyl, a group --SO.sub.2 OMe, wherein Me is a metal atom selected from the group which consists of sodium or potassium, or a group --SO.sub.2 R.sup.6 in which R.sup.6 is alkyl having 1 to 4 carbon atoms, 4-methylphenyl, amino, C.sub.1 to C.sub.4 alkoxycarbonyl-amino, or benzoylamino, or R.sup.10 is a group ##STR2## in which R.sup.7 is cycloalkyl having 5 to 6 carbon atoms, and R is vinyl. The compounds are intermediates useful in the preparation of arylacetic acids having antiinflammatory compounds.Type: GrantFiled: March 23, 1981Date of Patent: May 24, 1983Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Endre Palosi, Dezso Korbonits, Pal Kiss, Csaba Gonczy, Gergely Heja, Judit Cser nee Kun, Rudolf Szebeni, Maria Szomor nee Wundele, Ida Szvoboda nee Kanzel
-
Patent number: 4317920Abstract: Arylacetic acid derivatives of the formula ##STR1## with R.sup.1, R.sup.2 and R.sup.3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are practiced by catalytic hydrogenation of new compounds of the formula ##STR2## in which R and R.sup.10 are also specifically defined. The method of making the latter compound is also set forth.Type: GrantFiled: May 21, 1979Date of Patent: March 2, 1982Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Endre Palosi, Dezso Korbonits, Pal Kiss, Csaba Gonczy, Gergely Heja, Judit Cser nee Kun, Rudolf Szebeni, Maria Szomor nee Wundele, Ida Szvoboda nee Kanzel
-
Patent number: 4304938Abstract: 3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.Type: GrantFiled: December 21, 1979Date of Patent: December 8, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Endre Palosi, Gergely Heja, Dezso Korbonits, Pal Kiss, Csaba Gonczi, Judit Cser nee Kun, Ida Szvoboda nee Kauzel, Gabor Kovacs, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky