Abstract: A system and method of COVID-19 Detection, Spread Prevention and Medical Assistance Using Machine Learning. The Machine Learning (ML) techniques have been generally utilized in different spaces, there is presently a popularity for ML-helped analysis frameworks for screening, following, and anticipating the spread of COVID-19 and discovering a fix against it. According to one embodiment, the system comprises IoT module, a warm imaging, a social distance monitoring, contact tracing module, and Media analysis based on which the system estimates the and detects the infection. Fundamentally taking a gander at it from a screening, gauging, and antibody points of view, the present system conducts an exhaustive review of the ML calculations and models that can be utilized on this campaign and help with engaging the infection.