Abstract: A media pack includes a filtration sheet and a support sheet engaged with the filtration sheet. The support sheet includes a first perforated sheet and a first media sheet, the first perforated sheet and the first media sheet being corrugated. The filtration sheet and the support sheet are wound together in a substantially spiral shape. The filtration sheet and the support sheet together form a plurality of channels that are alternatively sealed on opposing ends of the media pack.

Abstract: The present invention includes method and device for label-free holographic screening and enumeration of tumor cells in bulk flow comprising: a laser source, a micro-objective, a pinhole device and a collimating lens, a mirror, a sample chamber with a sample flow inlet on a first side of the sample chamber and a sample flow outlet connected by a microchannel, and a detector, wherein the collimated laser beam passes through microchannel and interacts with cells in the sample to generate a respective hologram at the detector, wherein a processor calculates a numerical reconstruction from the respective hologram and generates a focused image of the numerous cells using the numerical reconstruction, wherein the numerous cells are enumerated by looking at a size, a maximum intensity and a mean intensity of the focused image.

Abstract: The present invention includes method and device for label-free holographic screening and enumeration of tumor cells in blood for use in connection with cancer treatments and monitoring.