Abstract: A method for synthesizing ultrasmall gelatin nanoparticles. A first desolvation is conducted to produce gelatin strands in a first solution and then setting the pH of the solution to charge and separate the strands. Tripolyphosphate (TPP) is added to the first solution to form gelatin-TPP-gelatin bridges. Second desolvation of the gelatin-TPP-gelatin bridges is conducted in a second solution. The second solution contains an TPP-Ethanol:Acetone mixture in a ratio between 1:1 and 1:5 and TPP between 0.005-0.025 vol % or a Glutaraldehyde-Ethanol:Acetone mixture in a ratio of glutaraldehyde-ethanol:Acetone range of 2.5-12% v/v to produce a colloid of self-assembled gelatin nanoparticles. The method can produce nanomaterial consisting of a plurality of gelatin nanoparticles sized at ˜10 nm. The nanomaterial can encapsulate a drug, metal nanoparticle or contrast agent.

Abstract: Provided herein are methods and compositions for sensitizing a cancer cell to a cancer treatment, for example to an anticancer drug by the inhibition of at least two cancer biomarkers. Further provided are methods of treating and/or preventing a cancer including reducing the size of a tumor. Also provided are compositions comprising nanopartides associated with inhibitory molecules, such as siRNA, and/or anti-cancer drugs.

Abstract: Provided herein are methods and compositions for sensitizing a cancer cell to a cancer treatment, for example to an anticancer drug by the inhibition of at least two cancer biomarkers. Further provided are methods of treating and/or preventing a cancer including reducing the size of a tumor. Also provided are compositions comprising nanopartides associated with inhibitory molecules, such as siRNA, and/or anti-cancer drugs.

Abstract: Provided are nanoparticle conjugates comprising a drug encapsulated in a gelatin nanoparticle the surface of which is functionalized with an antibody to which a siRNA is linked. Methods with the nanoconjugates for treating diseases are provided as well.

Abstract: Provided are nanoparticle conjugates comprising a drug encapsulated in a gelatin nanoparticle the surface of which is functionalized with an antibody to which a siRNA is linked. Methods with the nanoconjugates for treating diseases are provided as well.

Abstract: A composition comprising one or more antibodies covalently attached to a magnetic nanoparticle via a linker. The magnetic nanoparticle comprises a magnetic core and a non-magnetic outer surface layer. The one or more antibodies are specific for one or more target cells or one or more target biomolecules in a biological sample. The linker comprises ethylene glycol and/or thiol. The invention also provides methods for fabricating such antibody conjugated nanoparticles and procedures for their applications in selective separation/isolation of target cells or target biomolecules from biological matters.