Patents by Inventor Dhanir Tailor

Dhanir Tailor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Y BOX BINDING PROTEIN 1 INHIBITORS
    Publication number: 20240016784
    Abstract: Provided herein are novel azopodophyllotoxin analog compounds, pharmaceutical compositions comprising them, and their use as inhibitors of Y box protein 1 (YB1 or YBX1) in treatments for conditions including gynecological, breast, bladder, kidney, head and neck, neuronal, and prostate cancers, lymphomas, and leukemias. Methods of their use in sensitizing resistant cancers to treatment with anticancer agents and radiation are also provided.
    Type: Application
    Filed: December 3, 2021
    Publication date: January 18, 2024
    Applicants: Oregon Health & Science University, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sanjay V. Malhotra, Dhanir Tailor, Arpit Dheeraj
  • N-hydroxyethyl didehydroazapodophyllotoxins as GBP1 inhibitors and methods of overcoming treatment resistance in cancer
    Patent number: 11771692
    Abstract: Compounds, compositions and methods are provided for the inhibition of GBP1. The subject inhibitor compounds can act by inhibiting GBP1 alone and/or GBP1: pro-survival kinase (e.g. serine/threonine-protein kinase pim-1 (PIM1)) interactions. Aspects of the subject methods include contacting a cellular sample with a GBP 1 inhibitor to inhibit the GBP 1 alone and/or GBP 1: PIM 1 interactions. Also provided are compositions and methods for treating cancer. In certain cases the cancer is resistant towards chemotherapy and radiation therapy.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: October 3, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sanjay Malhotra, Vineet Kumar, Dhanir Tailor
  • METHOXYCHALCONE DERIVATIVES AND USES THEREOF
    Publication number: 20210347724
    Abstract: Methoxychalone derivatives with anti-cancer activity are provided.
    Type: Application
    Filed: May 4, 2021
    Publication date: November 11, 2021
    Inventors: Meghan A. Rice, Vineet Kumar, Dhanir Tailor, Sanjay V. Malhotra, Tanya Stoyanova
  • NOVEL N-HYDROXYETHYL DIDEHYDROAZAPODOPHYLLOTOXINS AS GBP1 INHIBITORS AND METHODS OF OVERCOMING TREATMENT RESISTANCE IN CANCER
    Publication number: 20200375977
    Abstract: Compounds, compositions and methods are provided for the inhibition of GBP1. The subject inhibitor compounds can act by inhibiting GBP1 alone and/or GBP1: pro-survival kinase (e.g. serine/threonine-protein kinase pim-1 (PIM1)) interactions. Aspects of the subject methods include contacting a cellular sample with a GBP 1 inhibitor to inhibit the GBP 1 alone and/or GBP 1: PIM 1 interactions. Also provided are compositions and methods for treating cancer. In certain cases the cancer is resistant towards chemotherapy and radiation therapy.
    Type: Application
    Filed: March 12, 2019
    Publication date: December 3, 2020
    Inventors: Sanjay Malhotra, Vineet Kumar, Dhanir Tailor