Patents by Inventor Dharmendra Saikia
Dharmendra Saikia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9018226Abstract: The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and ?-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R.Type: GrantFiled: March 31, 2010Date of Patent: April 28, 2015Assignee: Council of Scientific & Industrial ResearchInventors: Santosh Kumar Srivastava, Ashok Kumar Agrawal, Subhash Chandra Singh, Vinay Kumar Khanna, Janardan Singh, Chandeshwar Nath, Madan Mohan Gupta, Shikha Gupta, Ram Kishor Verma, Anirban Pal, Dnyaneshwar Umrao Bawankule, Dharmendra Saikia, Anil Kumar Gupta, Anupam Maurya, Suman Preet Singh Khanuja
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Publication number: 20120184576Abstract: The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-der?ethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and ?-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkabids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R.Type: ApplicationFiled: March 31, 2010Publication date: July 19, 2012Inventors: Santosh Kumar Srivastava, Ashok Kumar Agrawal, Subhash Chandra Singh, Vinay Kumar Khanna, Janardan Singh, Chandeshwar Nath, Madan Mohan Gupta, Shikha Gupta, Ram Kishor Verma, Anirban Pal, Duyaneshwar Umrao Bawankule, Dharmendra Saikia, Anil Kumar Gupta, Anupam Maurya, Suman Preet Singh Khanuja
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Patent number: 7291349Abstract: The present invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungus. More particularly, the present invention relates to the synergistic enhancement of activity of a combination by menthyl acetate or Geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations.Type: GrantFiled: January 21, 2004Date of Patent: November 6, 2007Inventors: Suman Preet Singh Khanuja, Pushplata Chaturvedi, Anil Kumar Singh, Ajit Kumar Shasany, Vinay Kumar Agarwal, Vivek Kumar Gupta, Subhash Chandra Gupta, Arun Kumar Tripathy, Anirban Pal, Dharmendra Saikia, Mahendra Pandurang Darokar, Krishna Kumar Aggarwal, Ravi Prakash Bansal
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Patent number: 7262004Abstract: An in vitro screening method for identifying insect tolerant genotypes or clones is described. The method comprises growing plantlets in an in vitro system, screening the plantlets for molecular variation of somaclones using RAPD analysis in vitro, selecting the somaclones having molecular variation, exposing the somaclones to insect larvae or nymphs and identifying the surviving somaclones.Type: GrantFiled: January 18, 2000Date of Patent: August 28, 2007Assignee: Council of Scientific and Industrial ResearchInventors: Suman Preet Singh Khanuja, Ajit Kumar Shasany, Sunita Dhawan, Mahendra Pandurang Darokar, Sarita Satapathy, Tiruppadiripuliyur Ranganathan Santha Kumar, Dharmendra Saikia, Nirmal Kumar Patra, Janak Raj Bahl, Arun Kumar Tripathy, Sushil Kumar
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Patent number: 7262003Abstract: The present invention relates to a method of testing Bacopa monnieri response to abiotic stress factors and for testing bioactivity of natural, synthetic and semisynthetic compounds using Bacopa monnieri plant, which comprises growing the said plant and plant parts aseptically in MS 0 basal medium with agar in microcentrifuge tubes by adding the compounds to be tested either to the culture media or by spraying the said compounds on the plant or plant parts or on the said medium to detect the distinct morphological and cytological responses.Type: GrantFiled: December 13, 2002Date of Patent: August 28, 2007Assignee: Council of Scientific and Industrial ResearchInventors: Sushil Kumar, Suman Preet Singh Khanuja, Mahendra Pandurang Darokar, Tiruppadiripuliyur Ranganathan Santha Kumar, Anita Gangwar, Ajit Kumar Shasany, Srilekha Mishra, Shalini Mathur, Dharmendra Saikia
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Publication number: 20070099993Abstract: The present invention relates to the new use of an already known biomolecule methyl-?-orcinol carboxylate of formula I isolated from a lichen (Everniastrum cirrhatum), for treating pathogenic fungal infections of humans that are resistant to polyene and azole antibiotics such as amphotericin B, nystatin, clotrimazole etc.Type: ApplicationFiled: December 7, 2006Publication date: May 3, 2007Inventors: Suman Khanuja, Ranganathan Tiruppadiripuliyur, Vivek Gupta, Preeti Chand, Ankur Garg, Santosh Srivastava, Subash Verma, Dharmendra Saikia, Mahendra Darokar, Ajit Shasany, Anirban Pal
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Publication number: 20050181081Abstract: The present invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungus. More particularly, the present invention relates to the synergistic enhancement of activity of a combination by menthyl acetate or Geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations.Type: ApplicationFiled: January 21, 2004Publication date: August 18, 2005Inventors: Suman Khanuja, Pushplata Chaturvedi, Anil Singh, Ajit Shasany, Vinay Agarwal, Vivek Gupta, Subhash Gupta, Arun Tripathy, Anirban Pal, Dharmendra Saikia, Mahendra Darokar, Krishna Aggarwal, Ravi Bansal
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Publication number: 20050044600Abstract: The present invention relates to the development of a novel multiutility vigorously growing robust mint plant ‘Ganga’ of Mentha spicata L. var. viridis producing essential oil exhibiting anti-insect and anti-microbial activities and useful for agrochemical and pharmaceutical purposes.Type: ApplicationFiled: May 7, 2004Publication date: February 24, 2005Applicant: Council of Scientific and Industrial ResearchInventors: Suman Khanuja, Sushil Kumar, Ajit Shasany, Sunita Dhawan, Mahendra Darokar, Arun Tripathy, Sarita Satapathy, Tiruppadiripuliyur Kumar, Vivek Gupta, Arvind Tripathi, Soumya Awasthi, Veena Prajapati, Ali Naqvi, Krishna Agrawal, Janak Bahl, Anil Singh, Ateeque Ahmed, Ravi Bansal, Alok Krishna, Dharmendra Saikia
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Patent number: 6858588Abstract: The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (?) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.Type: GrantFiled: March 31, 2003Date of Patent: February 22, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Suman Preet Singh Khanuja, Jai Shanker Arya, Ranganathan Santha Kumar Tiruppadiripuliyur, Dharmendra Saikia, Harpreet Kaur, Monika Singh, Subhash Chandra Gupta, Ajit Kumar Shasany, Mahendra Pandurang Darokar, Santosh Kumar Srivastava, Madan Mohan Gupta, Subash Chandra Verma, Anirban Pal
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Patent number: 6824795Abstract: A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.Type: GrantFiled: December 19, 2002Date of Patent: November 30, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Suman Preet Singh Khanuja, Suchi Srivastava, Ajit Kumar Shasney, Mahendra Pandurang Darokar, Tiruppadiripuliyur Ranganathan Santha Kumar, Krishna Kumar Agarwal, Ateeque Ahmed, Nirmal Kumar Patra, Prachi Sinha, Sunita Dhawan, Dharmendra Saikia, Sushil Kumar
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Publication number: 20040198669Abstract: The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.Type: ApplicationFiled: March 31, 2003Publication date: October 7, 2004Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Suman Preet Singh Khanuja, Jai Shanker Arya, Ranganathan Santha Kumar Tiruppadiripuliyur, Dharmendra Saikia, Harpreet Kaur, Monika Singh, Subhash Chandra Gupta, Ajit Kumar Shasany, Mahendra Pandurang Darokar, Santosh Kumar Srivastava, Madan Mohan Gupta, Subash Chandra Verma, Anirban Pal
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Publication number: 20040198815Abstract: The present invention relates to the new use of an already known biomolecule methyl-&bgr;-orcinol carboxylate of formula 1 isolated from a lichen (Everniastrum cirrhatum), for treating pathogenic fungal infections of humans that are resistant to polyene and azole antibiotics such as amphotericin B, nystatin, clotrimazole etc.Type: ApplicationFiled: March 31, 2003Publication date: October 7, 2004Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Suman Preet Singh Khanuja, Ranganathan Santha Kumar Tiruppadiripuliyur, Vivek Kumar Gupta, Preeti Chand, Ankur Garg, Santosh Kumar Srivastava, Subash Chandra Verma, Dharmendra Saikia, Mahendra Pandurang Darokar, Ajit Kumar Shasany, Anirban Pal
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Publication number: 20040029098Abstract: The present invention relates to a method of testing Bacopa monnieri response to abiotic stress factors and for testing bioactivity of natural, synthetic and semisynthetic compounds using Bacopa monnieri plant, which comprises growing the said plant and plant parts aseptically in MS 0 basal medium with agar in microcentrifuge tubes by adding the compounds to be tested either to the culture media or by spraying the said compounds on the plant or plant parts or on the said medium to detect the distinct morphological and cytological responses.Type: ApplicationFiled: December 13, 2002Publication date: February 12, 2004Applicant: Council of Scientific and Industrial ResearchInventors: Sushil Kumar, Suman Preet Singh Khanuja, Mahendra Pandurang Darokar, Tiruppadiripuliyur Ranganathan Santha Kumar, Anita Gangwar, Ajit Kumar Shasany, Srilekha Mishra, Shalini Mathur, Dharmendra Saikia
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Publication number: 20030175283Abstract: A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.Type: ApplicationFiled: December 19, 2002Publication date: September 18, 2003Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Suman Preet Singh Khanuja, Suchi Srivastava, Ajit Kumar Shasney, Mahendra Pandurang Darokar, Tiruppadiripuliyur Ranganathan Santha Kumar, Krishna Kumar Agarwal, Ateeque Ahmed, Nirmal Kumar Patra, Prachi Sinha, Sunita Dhawan, Dharmendra Saikia, Sushil Kumar
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Patent number: 6514541Abstract: A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.Type: GrantFiled: March 28, 2000Date of Patent: February 4, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Suman Preet Singh Khanuja, Suchi Srivastava, Ajit Kumar Shasney, Mahendra Pandurang Darokar, Tiruppadiripuliyur Ranganathan Santha Kumar, Krishna Kumar Agarwal, Ateeque Ahmed, Nirmal Kumar Patra, Prachi Sinha, Sunita Dhawan, Dharmendra Saikia, Sushil Kumar
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Patent number: 6423741Abstract: This invention is related to the development of strategic and novel composition comprising &agr; arteether and nalidixic acid or quinolone drugs, said composition useful as an advanced generation drug to counter the resistance development itself and having a potential to be used in treating infectious diseases and in inhibiting the resistance developed due to mutation in the gyr A gene of bacteria, particularly in those cases where drug resistant strains are known to appear very frequently.Type: GrantFiled: March 29, 2000Date of Patent: July 23, 2002Assignee: Council of Scientific and Industrial ResearchInventors: Suman Preet Singh Khanuja, Suchi Srivastava, Tiruppadiripuliyur Ranganathan Santha Kumar, Ajit Kumar Shasany, Dharam Chand Jain, Mahendra Pandurang Darokar, Dharmendra Saikia, Sushil Kumar
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Patent number: 6423541Abstract: The invention provides a rapid in vitro method for selection of menthol rich mint genotypes from a large population of independent clones, said method comprising the steps of (i) raising a heterogeneous population of Mentha arvensis clones in vitro or by vegetative methods, (ii) transferring the plantlets/shoots to a basal medium, containing cytotoxic compounds in an amount sufficient to cause toxic effect in more than 95% of the clones, (iii) selecting surviving clones, their hardening in the glasshouse, transfer to field, reconfirmation of menthol tolerance through repeated in vitro assays, and (iv) multiplying selected clones and confirming genetic uniformity through RAPD analysis.Type: GrantFiled: March 21, 2000Date of Patent: July 23, 2002Assignee: Council of Scientific&Industrial ReaearchInventors: Suman Preet Singh Khanuja, Ajit Kumar Shasany, Sunita Dhawan, Mahendra Pandurang Darokar, Tiruppadiripuliyur Ranganathan Santha Kumar, Dharmendra Saikia, Arif Ali Naqui, Sushil Kumar
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Patent number: 6420174Abstract: The present invention is related to a method of producing organogenetic tissues from a plant of the genus Mentha, said method comprising the steps of culturing an explant from a plant of genus Mentha on an initiation medium in the presence of 400 to 600 lux light at a temperature of 23-27° C., with 16 hours of photoperiod, to obtain calli, transferring the calli to a basal medium comprising minerals and vitamins to ensure development of shoots, and culturing the shoots in a medium substantially free of growth hormones and containing menthol in a concentration of about 80 &mgr;g ml−1 to ensure root formation.Type: GrantFiled: March 28, 2000Date of Patent: July 16, 2002Assignee: Council of Scientific and Industrial ResearchInventors: Suman Preet Singh Khanuja, Ajit Kumar Shasany, Sunita Dhawan, Mahendra Pandurang Darokar, Tiruppadiripuliyur Ranganathan Santha Kumar, Dharmendra Saikia, Sushil Kumar
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Patent number: PP16747Abstract: The present invention relates to the development of a novel multiutility vigorously growing robust mint plant ‘Ganga’ of Mentha spicata L. var. viridis producing essential oil exhibiting anti-insect and anti-microbial activities and useful for agrochemical and pharmaceutical purposes.Type: GrantFiled: May 7, 2004Date of Patent: July 4, 2006Assignees: Council of Scientific and Industrial Research, Department of BiotechnologyInventors: Suman P. S. Khanuja, Sushil Kumar, Ajit K. Shasany, Sunita Dhawan, Mahendra P. Darokar, Arun K. Tripathy, Sarita Satapathy, Tiruppadiripuliyur R. S. Kumar, Vivek K. Gupta, Arvind K. Tripathi, Soumya Awasthi, Veena Prajapati, Ali A. Naqvi, Krishna K. Agrawal, Janak R. Bahl, Anil K. Singh, Ateeque Ahmed, Ravi P. Bansal, Alok Krishna, Dharmendra Saikia
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Patent number: PP14538Abstract: The present invention relates to a novel, insect tolerant, high yielding essential oil and menthol yielding mint plant named ‘Sambhav’, which is a cultivar of Mentha arvensis L.. The mint plant of the present invention has been developed as a result of planned experiments which devised a procedure for early selection of somaclonal variants at the in vitro stage of the variety of Mentha arvensis.Type: GrantFiled: January 18, 2000Date of Patent: February 17, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Suman Preet Singh Khanuja, Ajit Kumar Shasany, Sunita Dhawan, Mahendra Pandurang Darokar, Sarita Satapathy, Tiruppadiripuliyur Ranganathan Santha Kumar, Dharmendra Saikia, Nirmal Kumar Patra, Janak Raj Bahl, Arun Kumar Tripathy, Sushil Kumar