Patents by Inventor Dharmesh R. Tailor

Dharmesh R. Tailor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8554305
    Abstract: Prior approaches have delivered 17O2 to a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by H217O created in non-cerebral tissues. During a brief pulse of 17O2 inhalation, this arterial input function for H217O is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation of 17O2 even more effective. Accordingly, ventilator system are provided to deliver 17O2 as a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of H217O in the cerebral ventricles, suggesting that the arterial input function of H217O is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: October 8, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dharmesh R. Tailor, James E. Baumgardner, Ravinder Reddy
  • Publication number: 20100282258
    Abstract: Prior approaches have delivered O2 to a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by H217O created in non-cerebral tissues. During a brief pulse of 17O2 inhalation, this arterial input function for H217O is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation of 17O2 even more effective. Accordingly, ventilator system are provided to deliver 17O2 as a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of H217O in the cerebral ventricles, suggesting that the arterial input function of H217O is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.
    Type: Application
    Filed: July 18, 2008
    Publication date: November 11, 2010
    Applicant: The Trustee of the University of Pennsylvania
    Inventors: Dharmesh R. Tailor, James E. Baumgardner, Ravinder Reddy