Patents by Inventor Dhaya Seshasayee

Dhaya Seshasayee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20240117037
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: June 30, 2023
    Publication date: April 11, 2024
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ANTI-INTERLEUKIN-33 ANTIBODIES AND USES THEREOF
    Publication number: 20240092887
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of making and using the same, e.g., for treatment of IL-33 mediated disorders (e.g., ocular disorders such as AMD (e.g., geographic atrophy (GA)).
    Type: Application
    Filed: August 2, 2023
    Publication date: March 21, 2024
    Inventors: Gerald R. NAKAMURA, Dhaya SESHASAYEE, Menno VAN LOOKEREN CAMPAGNE, Tiffany WONG, Jia WU, Hongkang XI, Jack BEVERS, III, Hiu Nam CHAN, Laetitia COMPS-AGRAR, Racquel CORPUZ
  • Isoform-selective anti-TGF? antibodies and methods of use
    Patent number: 11919948
    Abstract: The invention provides isoform-selective anti-TGF? antibodies and methods of using the same. In particular, isoform-selective anti-TGF?2, anti-TGF?3, and anti-TGF?2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGF?-related disorders.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: March 5, 2024
    Assignee: GENENTECH, INC.
    Inventors: Wei-Ching Liang, Joseph R. Arron, Daryle Depianto, Wendy Green Halpern, WeiYu Lin, Patrick J. Lupardus, Thirumalai Rajan Ramalingam, Dhaya Seshasayee, Tianhe Sun, Tulika Tyagi, Jia Wu, Yan Wu, Jian Ping Yin
  • Anti-interleukin-33 antibodies and uses thereof
    Patent number: 11760797
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of making and using the same, e.g., for treatment of IL-33 mediated disorders (e.g., ocular disorders such as AMD (e.g., geographic atrophy (GA)).
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: September 19, 2023
    Assignee: Genentech, Inc.
    Inventors: Gerald R. Nakamura, Dhaya Seshasayee, Menno Van Lookeren Campagne, Tiffany Wong, Jia Wu, Hongkang Xi, Jack Bevers, III, Hiu Nam Chan, Laetitia Comps-Agrar, Racquel Corpuz
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20230279102
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: December 7, 2022
    Publication date: September 7, 2023
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • Anti-interleukin-33 antibodies and uses thereof
    Patent number: 11725050
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: August 15, 2023
    Assignee: Genentech, Inc.
    Inventors: Philip E. Hass, Meredith Hazen, Yi-Chun Hsiao, Rajita Khosla, Gerald R. Nakamura, Dhaya Seshasayee, Menno Van Lookeren Campagne, Hongkang Xi, Wenwu Zhai, Jack Bevers, III, Nancy Chiang
  • Agonists of TREM2
    Publication number: 20220389097
    Abstract: This application discloses, inter alia, certain antibodies that specifically bind to human TREM2 (triggering receptor expressed on myeloid cells 2). In some embodiments, the antibodies act as TREM2 agonists. In some embodiments, antibodies herein specifically bind to the stalk region of intact, human TREM2, without binding to soluble TREM2, which is the product of TREM2 cleavage between residues H157 and S158. In some embodiments, the antibodies act as TREM2 agonists, specifically bind to the stalk region of TREM2 with dissociation constants ranging from 10 nM to as low as 100-500 pM, 10-50pM, or 1-10 pM, specifically bind to a TREM2 epitope spanning the H157-S158 cleavage site, and do not bind to soluble TREM2.
    Type: Application
    Filed: May 12, 2022
    Publication date: December 8, 2022
    Applicant: Genentech Inc.
    Inventors: Ainhoa Echeverria Larraza, David Verne Hansen, Isidro Hotzel, Yi-Chun Hsiao, Zhonghua Lin, Dhaya Seshasayee, Benny Chih
  • DEVELOPING AN EFFICIENT HYBRIDOMA PLATFORM FOR THERAPEUTIC ANTIBODY DISCOVERY
    Publication number: 20220177551
    Abstract: The instant technology generally relates to improved methods for producing antibodies, antibody libraries, hybridomas, hybridoma libraries, etc. For example, these methods increase the number of antigen-specific B cells produced, increase the number of hybridomas, and/or increase the number of monoclonal antibodies that can be made in a given production cycle.
    Type: Application
    Filed: February 25, 2022
    Publication date: June 9, 2022
    Inventors: Meredith Carroll HAZEN, Zhonghua LIN, Dhaya SESHASAYEE
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20220064286
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: November 15, 2021
    Publication date: March 3, 2022
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ISOFORM-SELECTIVE ANTI-TGF-BETA ANTIBODIES AND METHODS OF USE
    Publication number: 20210301005
    Abstract: The invention provides isoform-selective anti-TGF? antibodies and methods of using the same. In particular, isoform-selective anti-TGF?2, anti-TGF?3, and anti-TGF?2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGF?-related disorders.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 30, 2021
    Applicant: Genentech, Inc.
    Inventors: Wei-Ching LIANG, Joseph R. ARRON, Daryle DEPIANTO, Wendy Green HALPERN, WeiYu LIN, Patrick J. LUPARDUS, Thirumalai Rajan RAMALINGAM, Dhaya SESHASAYEE, Tianhe SUN, Tulika TYAGI, Jia WU, Yan WU, Jian Ping YIN
  • ANTI-INTERLEUKIN-33 ANTIBODIES AND USES THEREOF
    Publication number: 20210284725
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of making and using the same, e.g., for treatment of IL-33 mediated disorders (e.g., ocular disorders such as AMD (e.g., geographic atrophy (GA)).
    Type: Application
    Filed: March 12, 2021
    Publication date: September 16, 2021
    Inventors: Gerald R. NAKAMURA, Dhaya SESHASAYEE, Menno VAN LOOKEREN CAMPAGNE, Tiffany WONG, Jiansheng WU, Hongkang XI, Jack BEVERS, III, Joyce CHAN, Laetitia COMPS-AGRAR, Racquel CORPUZ
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20210253693
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 19, 2021
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20210032328
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: October 6, 2020
    Publication date: February 4, 2021
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ANTI-INTERLEUKIN-33 ANTIBODIES AND USES THEREOF
    Publication number: 20210002361
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.
    Type: Application
    Filed: June 16, 2020
    Publication date: January 7, 2021
    Inventors: Philip E. HASS, Meredith HAZEN, Yi-Chun HSIAO, Rajita KHOSLA, Gerald R. NAKAMURA, Dhaya SESHASAYEE, Menno VAN LOOKEREN CAMPAGNE, Hongkang XI, Wenwu ZHAI, Jack BEVERS, III, Nancy CHIANG
  • Anti-interleukin-33 antibodies and uses thereof
    Patent number: 10723795
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: July 28, 2020
    Assignee: Genentech, Inc.
    Inventors: Philip E. Hass, Meredith Hazen, Yi-Chun Hsiao, Rajita Khosla, Gerald R. Nakamura, Dhaya Seshasayee, Menno Van Lookeren Campagne, Hongkang Xi, Wenwu Zhai, Jack Bevers, III, Nancy Chiang
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20190119376
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: May 31, 2018
    Publication date: April 25, 2019
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ANTI-INTERLEUKIN-33 ANTIBODIES AND USES THEREOF
    Publication number: 20190092852
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.
    Type: Application
    Filed: August 31, 2018
    Publication date: March 28, 2019
    Inventors: Philip E. HASS, Meredith HAZEN, Yi-Chun HSIAO, Rajita KHOSLA, Gerald R. NAKAMURA, Dhaya SESHASAYEE, Menno VAN LOOKEREN CAMPAGNE, Hongkang XI, Wenwu ZHAI, Jack BEVERS, III, Nancy CHIANG
  • Anti-interleukin-33 antibodies and uses thereof
    Patent number: 10093730
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: October 9, 2018
    Assignee: Genentech, Inc.
    Inventors: Philip E. Hass, Meredith Hazen, Yi-Chun Hsiao, Rajita Khosla, Gerald R. Nakamura, Dhaya Seshasayee, Menno Van Lookeren Campagne, Hongkang Xi, Wenwu Zhai, Jack Bevers, III, Nancy Chiang
  • Anti-TIGIT antibodies and methods of use
    Patent number: 10047158
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: August 14, 2018
    Assignee: Genentech, Inc.
    Inventors: Jane L. Grogan, Robert J. Johnston, Yan Wu, Wei-Ching Liang, Patrick Lupardus, Mahesh Yadav, Dhaya Seshasayee, Meredith Hazen
  • Anti-tigit antibodies and methods of use
    Patent number: 10017572
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 10, 2018
    Assignee: Genentech, Inc.
    Inventors: Jane L. Grogan, Robert J. Johnston, Yan Wu, Wei-Ching Liang, Patrick Lupardus, Mahesh Yadav, Dhaya Seshasayee, Meredith Hazen