Abstract: A process, and corresponding system for performing the process, is described for editing and representing property values for a digital map. The process stores a library of expressions for styling a digital map. The process retrieves electronic map data and displays a user interface including a property editor panel and a visual map portion. The property editor panel displays a plurality of map styles. The visual map portion displays a representation of the electronic map data. For a selected map style, the process displays a plurality of style properties and a text field for receiving expressions corresponding to a style property. The process receives, via the text field, an expression and determines a set of suggested expressions corresponding to the style property. The process applies the received expression to the electronic map data and renders in the visual map portion an edited representation of the electronic map data.

Abstract: A process, and corresponding system for performing the process, is described for editing and representing property values for a digital map. The process stores a library of expressions for styling a digital map. The process retrieves electronic map data and displays a user interface including a property editor panel and a visual map portion. The property editor panel displays a plurality of map styles. The visual map portion displays a representation of the electronic map data. For a selected map style, the process displays a plurality of style properties and a text field for receiving expressions corresponding to a style property. The process receives, via the text field, an expression and determines a set of suggested expressions corresponding to the style property. The process applies the received expression to the electronic map data and renders in the visual map portion an edited representation of the electronic map data.

Abstract: A method of screening a candidate compound for an ability to inhibit a cytochrome P450. The method includes the steps of reacting the candidate compound, an indicator compound precursor, a cytochrome P450 substrate, and the cytochrome P450, the cytochrome P450 characterized as having a side reaction associated with metabolic activity of the cytochrome P450 wherein a chemical species capable of reacting with the indicator compound precursor is produced; quantifying the amount of indicator compound produced in the presence of the candidate compound, and comparing the amount of indicator compound produced in the presence of the candidate compound to an amount of indicator produced under identical conditions in the absence of the candidate compound, the comparison indicating the ability of the candidate compound to inhibit the cytochrome P450. Also disclosed is a method for determining an inhibitory potency of a candidate compound for a cytochrome P450.

Abstract: The present invention provides methods and kits for determining the metabolic stability of compounds (e.g., stability to oxidative metabolism). In particular embodiments, the invention provides a method of determining the susceptibility of a compound to metabolism by an enzyme. In one representative embodiment, the enzyme is a cytochrome P450 enzyme. The invention is well-adapted for use in high throughput drug screening programs.