Abstract: This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

Abstract: This application discloses a three-dimensional human pose estimation method performed by a computer device. An initialization pose estimation result of a single video frame in a video frame sequence of n views is extracted based on a neural network model. Single-frame and single-view human pose estimation is performed on the initialization pose estimation result for each video frame, to obtain n single-view pose estimation sequences respectively corresponding to the n views. Single-frame and multi-view human pose estimation is performed according to single-view pose estimation results with the same timestamp in the n single-view pose estimation sequences, to obtain a multi-view pose estimation sequence. Multi-frame and multi-view human pose estimation is performed on a multi-view pose estimation result in the multi-view pose estimation sequence, to obtain a multi-view and multi-frame pose estimation result. Therefore, accuracy of human pose estimation is improved.

Abstract: Provided are a compound of formula (I) that inhibit the activity of PARP7, a stereoisomer thereof, a deuterated derivative thereof, or a pharmaceutically acceptable salt thereof, an intermediate to prepare the compound, a process to prepare the compound, a composition comprising the same, and the methods of using the same.

Abstract: This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

Abstract: This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

Abstract: A method, device, and apparatus for synthesizing a motion sequence of a virtual object and a non-transitory computer-readable storage medium are disclosed. The method can include obtaining description information of a motion sequence of a virtual object, and determining a continuous motion clip set similar to at least some motions in the motion sequence based on the description information and a continuous motion clip library constructed with video materials. The method can further include synthesizing the motion sequence of the virtual object based on the continuous motion clip set, where each continuous motion clip in the continuous motion clip library includes a unique identifier of the continuous motion clip, motion information of the continuous motion clip, and a representation vector corresponding to the each continuous motion clip.

Abstract: Disclosed is use of a compound in preventing and/or treating pathogen infection in animals. The compound is 4-(3-(((2-amino-5-(2-(1-methylpiperidin-4-yl)thiazol-5-yppyridin-3-ypoxy)methyl) phenyl)-2-methylbut-3-yn-2-ol, having a structure of formula I below. The compound can effectively treat diseases (such as feline infectious peritonitis) caused by pathogen (especially virus, such as coronavirus) infection in animals, improves the survival conditions of the animals, and has better commercial value and application prospect in the field of veterinary anti-pathogen (especially virus, such as coronavirus) therapies.

Abstract: This application discloses a three-dimensional human pose estimation method performed by a computer device. An initialization pose estimation result of a single video frame in a video frame sequence of n views is extracted based on a neural network model. Single-frame and single-view human pose estimation is performed on the initialization pose estimation result for each video frame, to obtain n single-view pose estimation sequences respectively corresponding to the n views. Single-frame and multi-view human pose estimation is performed according to single-view pose estimation results with the same timestamp in the n single-view pose estimation sequences, to obtain a multi-view pose estimation sequence. Multi-frame and multi-view human pose estimation is performed on a multi-view pose estimation result in the multi-view pose estimation sequence, to obtain a multi-view and multi-frame pose estimation result. Therefore, accuracy of human pose estimation is improved.

Abstract: A method, device, and apparatus for synthesizing a motion sequence of a virtual object and a non-transitory computer-readable storage medium are disclosed. The method can include obtaining description information of a motion sequence of a virtual object, and determining a continuous motion clip set similar to at least some motions in the motion sequence based on the description information and a continuous motion clip library constructed with video materials. The method can further include synthesizing the motion sequence of the virtual object based on the continuous motion clip set, where each continuous motion clip in the continuous motion clip library includes a unique identifier of the continuous motion clip, motion information of the continuous motion clip, and a representation vector corresponding to the each continuous motion clip.

Abstract: The present invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, the present invention provides a pharmaceutical composition comprising the said compound.

Abstract: The invention encompasses novel methods of operating electrochemical sensors such as aptamer-based sensors to analyze complex samples, such as flowing whole blood both in vitro or in vivo. In such environments, electrochemical sensors are often subject to drift, which complicates the interpretation of sensor output in terms of target concentration. The method of the invention utilizes a dual-reporter recognition element that generates a first, sensing current that is responsive to target binding and to environmental factors and a second, reference current that is only affected by environmental factors. The reference current provides information about environmentally-induced drift, which allows the drift effect to be subtracted out. By removing drift artifacts, electrochemical sensors may be deployed to analyze complex samples, such as whole blood, in vivo.

Abstract: This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: The invention encompasses novel methods of operating electrochemical sensors such as aptamer-based sensors to analyze complex samples, such as flowing whole blood both in vitro or in vivo. In such environments, electrochemical sensors are often subject to drift, which complicates the interpretation of sensor output in terms of target concentration. The method of the invention utilizes a dual-reporter recognition element that generates a first, sensing current that is responsive to target binding and to environmental factors and a second, reference current that is only affected by environmental factors. The reference current provides information about environmentally-induced drift, which allows the drift effect to be subtracted out. By removing drift artifacts, electrochemical sensors may be deployed to analyze complex samples, such as whole blood, in vivo.

Abstract: Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.

Abstract: This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.

Abstract: This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.