Abstract: System for individualized multiple-disease quantitative risk assessment, comprising: a database storing clinical data of patients with prognostic variables including biological signals; an analysis module for processing the biological signals for a given patient to automatically calculate prognostic parameters of diagnostic relevance for said patient; a risk-evaluation module for estimating, using a risk-evaluation model that considers predictor variables among the prognostic variables stored in the database and the prognostic parameters calculated by the analysis module, an individualized hazard ratio of having an event or developing a medical condition within a given period of time for the given patient; and an individualized multiple-disease quantitative risk assessment module for computing, based on the risk-evaluation model and specified thresholds for each of the predictor variables, a quantification of the risk for the given patient for each of the events or medical conditions under evaluation.