Abstract: The invention relates to the field of medicine and pharmaceuticals and particularly to a novel dosage form of an antitumor preparation, which ensures the hydrolytic and physical stability of said preparation, as well as to a method for producing a dosage form of this type. The stable dosage form is a lyophilizate comprising an etidronate-cytarabine conjugate or a pharmaceutically acceptable salt thereof, and a stabilizer, which is a divalent metal salt, in a molar ratio of stabilizer to conjugate of 1:1 to 20:1. A dosage form of this type ensures the hydrolytic and physical stability of the conjugate during long-term storage, and the stability of solutions of the conjugate for parenteral administration during clinical use.

Abstract: This invention relates to oncology, and specifically to a novel medicinal drug and a method for treating bone lesions caused by malignant neoplasms. A medicinal drug that represents a lyophilisate for solution for parenteral administration, including the following components: pharmaceutically acceptable salt of the divalent metal and 1-((((((2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy))(hydroxy)phosphoryloxy)(hydroxy)phosphoryl)-1-hydroxyethylphosphonic acid or pharmaceutically acceptable salt hereof with a molar ratio of the components ranging from 1:1 to 20:1 is proposed for this purpose. The treatment method includes the drug solution administration according to the invention in the form of intravenous drop infusions in a dose ranging from 0.01 to 5 mg/kg of the active component per 1 kg of the patient's weight in the form of intravenous drop infusions.

Abstract: This invention relates to oncology, and specifically to a novel medicinal drug and a method for treating bone lesions caused by malignant neoplasms. A medicinal drug that represents a lyophilisate for solution for parenteral administration, including the following components: pharmaceutically acceptable salt of the divalent metal and 1-((((((2R,3S,4S,5R)-5-(4-amino-2- oxopyrimidine-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy))(hydroxy)phosphoryloxy)(hydroxy)phosphoryl)-1-hydroxyethylphosphonic acid or pharmaceutically acceptable salt hereof with a molar ratio of the components ranging from 1:1 to 20:1 is proposed for this purpose. The treatment method includes the drug solution administration according to the invention in the form of intravenous drop infusions in a dose ranging from 0.01 to 5 mg/kg of the active component per 1 kg of the patient's weight in the form of intravenous drop infusions.

Abstract: Screenshots on a computer display are automatically captured to assist in building a tutorial to demonstrate the functionality of one or more applications. In one possible approach, an event detector, such as an accessibility toolkit, detects when events are generated by the one or more applications. The events may include, e.g., button clicks, windows opening or closing, drag and drop events, check boxes being checked, menus being pulled down or menu items selected, and so forth. Or, a program may monitor pixel changes on the screen to detect when changes occur in the images generated by the one or more applications. A tutorial builder application automatically captures an image when the event or image change is detected, edits the captured image such as by providing a focus on the changed portion, and provides the edited image in a tutorial window. Related text can also be automatically generated.

Abstract: Screenshots on a computer display are automatically captured to assist in building a tutorial to demonstrate the functionality of one or more applications. In one possible approach, an event detector, such as an accessibility toolkit, detects when events are generated by the one or more applications. The events may include, e.g., button clicks, windows opening or closing, drag and drop events, check boxes being checked, menus being pulled down or menu items selected, and so forth. Or, a program may monitor pixel changes on the screen to detect when changes occur in the images generated by the one or more applications. A tutorial builder application automatically captures an image when the event or image change is detected, edits the captured image such as by providing a focus on the changed portion, and provides the edited image in a tutorial window. Related text can also be automatically generated.