Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

Abstract: A foldable aquatic stepper includes: a foldable frame device, and a stepping device mounted on the frame device having a pair of paddling pedals reciprocatively and alternatively stepped upon for a smooth aquatic stepping exercise.

Abstract: A foldable aquatic stepper includes: a foldable frame device, and a stepping device mounted on the frame device having a pair of paddling pedals reciprocatively and alternatively trodden for a smooth aquatic stepping exercise.

Abstract: An amphibious foldable treadmill includes: a main frame having at least a wheel rotatably mounted on a base of the main frame to be rolled on a ground floor or on a pool bottom, a tread belt device pivotally secured to the main frame and unfolded from the main frame to be laid on the floor or pool bottom for treading operation, and a hand rail device pivotally secured to the main frame and pivotally connected with the tread belt device, whereby upon folding of the hand rail device and the tread belt device to the main frame, the treadmill can be folded for convenient handling, moving, launching in a pool or landing on the ground floor from the pool for successfully serving as an amphibious treadmill.

Abstract: An amphibious foldable treadmill includes: a main frame having at least a wheel rotatably mounted on a base of the main frame to be rolled on a ground floor or on a pool bottom, a tread belt device pivotally secured to the main frame and unfolded from the main frame to be laid on the floor or pool bottom for treading operation, and a hand rail device pivotally secured to the main frame and pivotally connected with the tread belt device, whereby upon folding of the hand rail device and the tread belt device to the main frame, the treadmill can be folded for convenient handling, moving, launching in a pool or landing on the ground floor from the pool for successfully serving as an amphibious treadmill.

Abstract: An in-line roller skate includes: a mounting plate having a footwear or boot secured on an upper surface of the mounting plate, and having a plurality of arcuate guiding rails respectively juxtapositionally transversely formed on a bottom of the mounting plate, with a longitudinal axis defining at a center of the mounting plate and projectively developing a vertical plane from the longitudinal axis towards a skating surface under the mounting plate; a plurality of cantilever members each slidably engageable with and movably adjustable on each arcuate guiding rail on the mounting plate; and a plurality of wheels each rotatably mounted on each cantilever member, whereby upon an angular adjustment of each cantilever member on each guiding rail, each wheel as rotatably mounted on each cantilever member will be angularly biased from the vertical plane for obtaining a preferred angle for the skater for ergonomically enhancing a skating maneuverability.

Abstract: A shoe buckle, especially for use on a roller skate boot, includes: a buckle body suspended and positioned on a central tongue of a shoe; two straps respectively secured to two upper side portions of a shoe upper and protruding inwardly to the buckle body of the shoe; a reel pivotally secured in the buckle body engageable with the two straps for fastening the two straps; a fastening device provided on a front or first end portion for driving the reel for fastening the straps for wearing the shoe on a wearer's foot; and a releasing device provided on a rear or second end portion for releasing the two straps for removing the shoe, thereby enabling a stable and convenient fastening of a shoe.

Abstract: A skate construction with pre-set buffering, shock-absorbing and the topogrphy compliance functions essentially composed of a footwear, a sole plate, a set of suspended support arms, a set of buffer wheels and a stop fixed block placed on the terminal portion of the sole plate, which is mainly characterized in that by employing a design of a low resistance rubber inflatable tire in combination with a single hub type support, a skate construction is given for keeping stable and smooth when the skate is used on lawns, concrete, unleveled or asphalt pavements.

Abstract: A wheel adapted for use on a roller skate or the like includes a wheel member made of elastomer having shock-absorbing property, and a pair of disk members embedded into a central hole of the wheel member, and combinable with each other for firmly clamping two central rim portions on two opposite sides of the wheel member, so that the wheel member secured with the two disk members will be stably rotatably mounted on an axle provided on a mounting frame of a roller skate, a skate board or any other wheeled sporting equipments for enhancing a better stability, heat resistance, shock-absorbing property and ground-treading property of the wheel.