Patents by Inventor Diana L. Clarke

Diana L. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9084787
    Abstract: The invention is directed to methods of promoting the healing of spinal cord injury. The invention is further directed to methods of minimizing the extent of scarring following spinal cord injury. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), each alone or in combination with each other and/or other agents.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: July 21, 2015
    Assignee: STEMNION, INC.
    Inventors: George L Sing, Diana L Clarke, Vivienne S Marshall
  • Patent number: 8475788
    Abstract: The invention is directed to methods of promoting the healing of spinal cord injury. The invention is further directed to methods of minimizing the extent of scarring following spinal cord injury. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), each alone or in combination with each other and/or other agents.
    Type: Grant
    Filed: November 27, 2007
    Date of Patent: July 2, 2013
    Assignee: Stemnion, Inc.
    Inventors: George L. Sing, Diana L. Clarke, Vivienne S. Marshall
  • Publication number: 20120301444
    Abstract: The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies.
    Type: Application
    Filed: July 3, 2012
    Publication date: November 29, 2012
    Inventors: Diana L. Clarke, Richard A. Banas
  • Publication number: 20120270319
    Abstract: The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies.
    Type: Application
    Filed: October 6, 2011
    Publication date: October 25, 2012
    Inventors: Diana L. Clarke, Charlotte A. Smith, Richard A. Banas, Vivienne S. Marshall
  • Patent number: 8278095
    Abstract: The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: October 2, 2012
    Assignee: Stemnion, Inc.
    Inventors: Diana L. Clarke, Charlotte A. Smith, Vivienne S. Marshall
  • Publication number: 20120230941
    Abstract: The invention is directed to methods for treating nervous system injury and disease, in particular traumatic brain injury and degenerative nervous system disease. Such methods utilize novel compositions, including but not limited to trophic factor-secreting extraembryonic cells (herein referred to as TSE cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), each alone or in combination with each other and/or other agents.
    Type: Application
    Filed: May 23, 2012
    Publication date: September 13, 2012
    Inventors: George L. Sing, Vivienne S. Marshall, Diana L. Clarke
  • Publication number: 20120164115
    Abstract: The invention is directed to methods related to surgery, for example gastrointestinal surgery. In particular, the invention is methods of treating fistulae, promoting accelerated healing of anastomoses and preventing failure of anastomoses. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.
    Type: Application
    Filed: February 15, 2012
    Publication date: June 28, 2012
    Inventors: Linda O. Palladino, Diana L. Clarke, Vivienne S. Marshall, Charlotte A. Smith, Martin C. Robson
  • Patent number: 8197804
    Abstract: The invention is directed to methods for treating nervous system injury and disease, in particular traumatic brain injury and degenerative nervous system disease. Such methods utilize novel compositions, including but not limited to trophic factor-secreting extraembryonic cells (herein referred to as TSE cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), each alone or in combination with each other and/or other agents.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: June 12, 2012
    Assignee: Stemnion, Inc.
    Inventors: George L. Sing, Vivienne S. Marshall, Diana L. Clarke
  • Patent number: 8153430
    Abstract: The invention is directed to methods related to surgery, for example gastrointestinal surgery. In particular, the invention is methods of treating fistulae, promoting accelerated healing of anastomoses and preventing failure of anastomoses. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: April 10, 2012
    Assignee: Stemnion, Inc.
    Inventors: Linda O. Palladino, Diana L. Clarke, Vivienne S. Marshall, Charlotte A. Smith, Martin C. Robson
  • Publication number: 20100129328
    Abstract: The invention is directed to methods for promoting hair growth. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.
    Type: Application
    Filed: July 21, 2008
    Publication date: May 27, 2010
    Inventors: George L. Sing, Vivienne S. Marshall, Diana L. Clarke, Charlotte A. Smith, Martin C. Robson
  • Publication number: 20100028306
    Abstract: The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies.
    Type: Application
    Filed: March 29, 2006
    Publication date: February 4, 2010
    Applicant: STEMNION, INC.
    Inventors: Diana L. Clarke, Charlotte A. Smith, Richard A. Banas, Vivienne S. Marshall
  • Publication number: 20090136457
    Abstract: The invention is directed to methods of promoting the healing of spinal cord injury. The invention is further directed to methods of minimizing the extent of scarring following spinal cord injury. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), each alone or in combination with each other and/or other agents.
    Type: Application
    Filed: November 27, 2007
    Publication date: May 28, 2009
    Inventors: George L. Sing, Diana L. Clarke, Vivienne S. Marshall
  • Publication number: 20090075381
    Abstract: The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies.
    Type: Application
    Filed: July 17, 2008
    Publication date: March 19, 2009
    Inventors: Diana L. Clarke, Charlotte A. Smith, Richard A. Banas, Vivienne S. Marshall
  • Publication number: 20090010899
    Abstract: The invention is directed to methods related to surgery, for example gastrointestinal surgery. In particular, the invention is methods of treating fistulae, promoting accelerated healing of anastomoses and preventing failure of anastomoses. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.
    Type: Application
    Filed: July 2, 2008
    Publication date: January 8, 2009
    Inventors: Linda O. Palladino, Diana L. Clarke, Vivienne S. Marshall, Charlotte A. Smith, Martin C. Robson
  • Publication number: 20090004161
    Abstract: The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.
    Type: Application
    Filed: June 25, 2008
    Publication date: January 1, 2009
    Inventors: Linda O. Palladino, Vivienne S. Marshall, Diana L. Clarke, Charlotte A. Smith, Martin C. Robson
  • Publication number: 20080286267
    Abstract: The invention is directed to methods for treating nervous system injury and disease, in particular traumatic brain injury and degenerative nervous system disease. Such methods utilize novel compositions, including but not limited to trophic factor-secreting extraembryonic cells (herein referred to as TSE cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), each alone or in combination with each other and/or other agents.
    Type: Application
    Filed: May 13, 2008
    Publication date: November 20, 2008
    Inventors: George L. Sing, Vivienne S. Marshall, Diana L. Clarke