Patents by Inventor Diana Quon

Diana Quon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of Abeta levels by beta-secretase BACE2
    Publication number: 20070224656
    Abstract: The present invention is based on the findings that BACE2, a homolog of ?-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A?. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress A? production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.
    Type: Application
    Filed: February 27, 2007
    Publication date: September 27, 2007
    Inventors: Barbara Cordell, Frauke Schimmoller, Yu-Wang Liu, Diana Quon
  • Novel beta-secretase and modulation of beta-secretase activity
    Publication number: 20060183160
    Abstract: The invention concerns a novel ?-secretase, a method of partially purifying this novel ?-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel ?-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.
    Type: Application
    Filed: April 12, 2006
    Publication date: August 17, 2006
    Applicant: Scios, Inc.
    Inventors: Ziyang Zhong, Barbara Cordell, Diana Quon, Yu-Wang Liu, Qiang Xu, Frauke Schimmoller, Paul Hyslop, Edward Johnstone, Sheila Little, Stephen Queener, Tinggui Yin