Patents by Inventor Diana S. Hamilton

Diana S. Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enone cancer therapeutics
    Patent number: 7569711
    Abstract: Described herein are new enone derivatives and conjugates. Additionally, methods for synthesizing these new enones are also disclosed. These compounds can be employed in cancer therapy.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: August 4, 2009
    Assignee: Cornell Univeristy
    Inventors: Bruce Ganem, Donald J. Creighton, Diana S. Hamilton, Zhebo Ding
  • Enone cancer therapeutics
    Publication number: 20030191066
    Abstract: New enone derivatives and conjugates are described. These compounds can be used as cancer therapeutics.
    Type: Application
    Filed: March 15, 2002
    Publication date: October 9, 2003
    Applicant: Cornell Research Foundation, Inc.
    Inventors: Bruce Ganem, Donald J. Creighton, Diana S. Hamilton, Zhebo Ding
  • Competitive inhibitors of glyoxalase I and method of generating such competitive inhibitors inside tumor cells
    Patent number: 5969174
    Abstract: The present invention provides a compound having the structure ##STR1## wherein S* is S.dbd.O or O.dbd.S.dbd.O; and wherein R.sub.1 is selected from the group consisting of (C.sub.1 -C.sub.9) alkyl, (C.sub.3 -C.sub.8) cycloalkyl, (C.sub.5 -C.sub.7) cycloalkenyl, and (C.sub.6 -C.sub.20) aryl substituted with halogen or (C.sub.1 -C.sub.18) alkyl; and wherein R.sub.2 is selected from the group consisting of alkyl, (C.sub.1 -C.sub.9) alkyl, (C.sub.3 -C.sub.8) cycloalkyl, (C.sub.5 -C.sub.7) cycloalkenyl, and (C.sub.6 -C.sub.20) aryl substituted with halogen or (C.sub.1 -C.sub.18) alkyl. Also provided are various methods of using the compositions of the present invention.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: October 19, 1999
    Assignee: University of Maryland at Baltimore County
    Inventors: Donald Creighton, Malcolm J. Kavarana, Diana S. Hamilton
  • Glutathione N-hydroxycarbamoyl thioesters and method of inhibiting neoplastic growth
    Patent number: 5616563
    Abstract: A compound of the formula ##STR1## with R being hydrogen, alkyl, cycloalkyl or aryl, which may be substituted with halogen or alkyl, and R' and R.sup.a being hydroxyl, or --O-alkyl, pharmaceutically acceptable salts thereof; or mixtures thereof. An anti-neoplastic composition comprises the compound described above and a pharmaceutically acceptable carrier. In vitro and in vivo methods of preventing or inhibiting the growth and proliferation of neoplastic cells and/or tumors comprise contacting the cells with or administering to a subject an anti-growth and proliferation effective amount of the compound described above.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: April 1, 1997
    Assignee: University of Maryland Baltimore Campus
    Inventors: Donald J. Creighton, Diana S. Hamilton