Patents by Inventor DIANA VIVIAN

DIANA VIVIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods to evaluate hepatobiliary/gastrointestinal health, enterohepatic circulation, and drug interactions
    Patent number: 9597417
    Abstract: The present invention relates to the synthesis and use of a novel trifluorinated bile acid analog, that being, CA-sar-TFMA which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analog can be used as a 19F MRI tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: March 21, 2017
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMETN OF VETERANS AFFAIRS
    Inventors: James E. Polli, Jean-Pierre Raufman, Diana Vivian
  • COMPOSITIONS AND METHODS TO EVALUATE HEPATOBILIARY/GASTROINTESTINAL HEALTH, ENTEROHEPATIC CIRCULATION, AND DRUG INTERACTIONS
    Publication number: 20150132228
    Abstract: The present invention relates to the synthesis and use of a novel trifluorinated bile acid analogue, that being, CA-sar-TFMA which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analogue can be used as a 19F MRI tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: JAMES E. POLLI, JEAN-PIERRE RAUFMAN, DIANA VIVIAN