Patents by Inventor Diana YANEZ

Diana YANEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coexpression of CAS9 and TREX2 for targeted mutagenesis
    Patent number: 11427819
    Abstract: A composition used in targeted mutagenesis is provided, which includes a first expression cassette comprising a nucleotide sequence which encodes a CAS9 endonuclease; a second expression cassette comprising a nucleotide sequence which encodes a guide RNA sequence, wherein the guide RNA sequence is complementary to a target genome nucleotide sequence in a cell; and a third expression cassette comprising a nucleotide sequence which encodes a Trex2 exonuclease (Trex2) gene. The first, second, and third expression cassettes may be a part or a portion of one or more expression vectors.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: August 30, 2022
    Assignee: CITY OF HOPE
    Inventors: Jeremy M. Stark, Diana Yanez
  • COEXPRESSION OF CAS9 AND TREX2 FOR TARGETED MUTAGENESIS
    Publication number: 20190093104
    Abstract: A composition used in targeted mutagenesis is provided, which includes a first expression cassette comprising a nucleotide sequence which encodes a CAS9 endonuclease; a second expression cassette comprising a nucleotide sequence which encodes a guide RNA sequence, wherein the guide RNA sequence is complementary to a target genome nucleotide sequence in a cell; and a third expression cassette comprising a nucleotide sequence which encodes a Trex2 exonuclease (Trex2) gene. The first, second, and third expression cassettes may be a part or a portion of one or more expression vectors.
    Type: Application
    Filed: December 5, 2018
    Publication date: March 28, 2019
    Inventors: Jeremy M. Stark, Diana Yanez
  • Coexpression of CAS9 and TREX2 for targeted mutagenesis
    Patent number: 10155938
    Abstract: A composition used in targeted mutagenesis is provided, which includes a first expression cassette comprising a nucleotide sequence which encodes a CAS9 endonuclease; a second expression cassette comprising a nucleotide sequence which encodes a guide RNA sequence, wherein the guide RNA sequence is complementary to a target genome nucleotide sequence in a cell; and a third expression cassette comprising a nucleotide sequence which encodes a Trex2 exonuclease (Trex2) gene. The first, second, and third expression cassettes may be a part or a portion of one or more expression vectors.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: December 18, 2018
    Assignee: CITY OF HOPE
    Inventors: Jeremy M. Stark, Diana Yanez
  • COEXPRESSION OF CAS9 AND TREX2 FOR TARGETED MUTAGENESIS
    Publication number: 20160304855
    Abstract: A composition used in targeted mutagenesis is provided, which includes a first expression cassette comprising a nucleotide sequence which encodes a CAS9 endonuclease; a second expression cassette comprising a nucleotide sequence which encodes a guide RNA sequence, wherein the guide RNA sequence is complementary to a target genome nucleotide sequence in a cell; and a third expression cassette comprising a nucleotide sequence which encodes a Trex2 exonuclease (Trex2) gene. The first, second, and third expression cassettes may be a part or a portion of one or more expression vectors.
    Type: Application
    Filed: April 14, 2016
    Publication date: October 20, 2016
    Inventors: Jeremy M. STARK, Diana YANEZ