Abstract: A method for fault diagnosis of a pressure sensor of an electro-hydraulic system with an explicit controller and an implicit controller in parallel is provided. The method may include receiving parameter information of the electro-hydraulic system; estimating a first chamber pressure of the hydraulic actuator online by utilizing a second chamber pressure of the hydraulic actuator; obtaining valve opening signals of the explicit controller and the implicit controller in a valve controller; converting the valve opening signals are difference-calculated to obtain two residual signals; and the residuals of an independent metering valve 1 and an independent metering valve 2 are compared with a preset threshold, respectively, to identify whether the independent metering valve 1 and the independent metering valve 2 are faulty or not. The method is simple to operate, has a fast response time and low cost for troubleshooting, and improves the diagnostic accuracy and coverage of the electro-hydraulic system.

Abstract: This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.