Patents by Inventor Diane Ellis-Busby
Diane Ellis-Busby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8541193Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or the absence of degradation of the peptide, as an indicator of the presence or absence of the enzyme in the sample, and thus indicative of the presence or absence of a microorganism in the sample. The present invention also features a biosensor for detecting the presence or absence of a microorganism in a sample.Type: GrantFiled: December 22, 2011Date of Patent: September 24, 2013Assignee: Systagenix Wound Management (US), Inc.Inventors: Mitchell T. Sanders, Gerard Colpas, Shite Sebastian, Diane Ellis-Busby
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Patent number: 8377651Abstract: Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: GrantFiled: September 30, 2010Date of Patent: February 19, 2013Assignee: Systagenix Wound Management (US), Inc.Inventors: Gerard J. Colpas, Diane Ellis-Busby, Shite Sebastian, Mitchell C. Sanders
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Publication number: 20120135440Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or the absence of degradation of the peptide, as an indicator of the presence or absence of the enzyme in the sample, and thus indicative of the presence or absence of a microorganism in the sample. The present invention also features a biosensor for detecting the presence or absence of a microorganism in a sample.Type: ApplicationFiled: December 22, 2011Publication date: May 31, 2012Applicant: Systagenix Wound Management (US), INC.Inventors: Mitchell C. Sanders, Gerard J. Colpas, Shite Sebastian, Diane Ellis-Busby
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Patent number: 8124370Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or the absence of degradation of the peptide, as an indicator of the presence or absence of the enzyme in the sample, and thus indicative of the presence or absence of a microorganism in the sample. The present invention also features a biosensor for detecting the presence or absence of a microorganism in a sample.Type: GrantFiled: January 30, 2004Date of Patent: February 28, 2012Assignee: Systagenix Wound Management (US), Inc.Inventors: Mitchell C. Sanders, Gerard J. Colpas, Shite Sebastian, Diane Ellis-Busby
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Publication number: 20110070594Abstract: Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: September 30, 2010Publication date: March 24, 2011Applicant: SYSTAGENIX WOUND MANAGEMENTInventors: Gerard J. Colpas, Diane Ellis-Busby, Shite Sebastian, Mitchell C. Sanders
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Publication number: 20070275423Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the ?1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: November 3, 2004Publication date: November 29, 2007Inventors: Shite Sebastian, Gerard Colpas, Diane Ellis-Busby, Jennifer Havard, Mitchell Sanders
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Publication number: 20070269851Abstract: Described herein is a substrate comprising at least one colorimetric component attached to a peptide, as well as methods for detecting a modification of said substrate. Also described are methods of detecting the presence or absence of a protein, for example, a protein produced by a microorganism, by contacting a substrate with a sample. If the sample contains the protein of interest, the substrate is modified and a visible color change results, indicating the presence or absence of the protein in the sample. The present invention also features biosensors and kits for detecting the presence or absence of microorganisms and/or proteins in a sample.Type: ApplicationFiled: November 3, 2004Publication date: November 22, 2007Inventors: Mitchell Sanders, Gerard Colpas, Diane Ellis-Busby, Jennifer Havard
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Publication number: 20070128589Abstract: Described herein are substrates, methods, articles, and kits that are useful for detecting a condition in a female mammal. The substrates interact with one or more proteins (e.g., an enzyme) produced by a microorganism or the female animal. The substrates are labelled in order to produce a visible signal (e.g., a fluorescent glow and/or a visible change in color or hue) when modified by a protein produced by a microorganism of interest. The visible signal is used to assess a condition in the female mammal.Type: ApplicationFiled: July 13, 2006Publication date: June 7, 2007Inventors: Mitchell Sanders, Diane Ellis-Busby, Jennifer Havard, John McCarty
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Publication number: 20060257955Abstract: Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: January 30, 2004Publication date: November 16, 2006Inventors: Gerard Colpas, Diane Ellis-Busby, Shite Sebastian, Mitchell Sanders
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Publication number: 20060240507Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or the absence of degradation of the peptide, as an indicator of the presence or absence of the enzyme in the sample, and thus indicative of the presence or absence of a microorganism in the sample. The present invention also features a biosensor for detecting the presence or absence of a microorganism in a sample.Type: ApplicationFiled: January 30, 2004Publication date: October 26, 2006Inventors: Mitchell Sanders, Gerard Colpas, Shite Sebastian, Diane Ellis-Busby
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Publication number: 20060205646Abstract: The present invention features methods of increasing cell or tissue viability by administering to the cell or tissue a protective protein. The invention also features methods of treating a condition characterized by cell or tissue damage in a subject by administering to the subject a protective protein. Also included are chimeric proteins as well as methods of inhibiting proteolysis of a cationic antimicrobial peptide in a cell or tissue including contacting the cell or tissue with a protective protein, chimeric protein that includes the protective protein, or a biologically active fragment, variant, or derivative thereof.Type: ApplicationFiled: November 11, 2005Publication date: September 14, 2006Inventors: Mitchell Sanders, Diane Ellis-Busby, Shite Sebastian
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Patent number: 7074175Abstract: Disclosed are compositions comprising magnetic nanoparticles, a biocompatible coating, and a target-specific ligand. Also disclosed are devices for treating diseased tissue for use with such compositions. Further disclosed are methods for treating diseased tissue, such as cancer, using such compositions and devices, as well as methods for treating diseased tissue utilizing hypertermia.Type: GrantFiled: June 18, 2002Date of Patent: July 11, 2006Inventors: Erik Schroeder Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman
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Patent number: 6997863Abstract: Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.Type: GrantFiled: July 19, 2002Date of Patent: February 14, 2006Assignee: Triton BioSystems, Inc.Inventors: Erik S. Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman, Susan J. Braunhut, Douglas U. Gwost, Blair Ardman
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Publication number: 20040156852Abstract: Methods for treating cells, diseased tissue, pathogens, or other undesirable matter involve the administration of a bioprobe (energy susceptive materials that are attached to a target-specific ligand) to a patient's body, body part, tissue, or body fluid (such as blood, blood plasma, or blood serum). An energy source provides energy to the bioprobe so as to destroy, rupture, or inactivate the target. Various energy forms, such as AMF, microwave, acoustic, or a combination thereof, created via a variety of mechanisms, may be used. The disclosed methods may be useful in the treatment of a variety of indications, including but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer, AIDS, adverse angiogenesis, restenosis, amyloidosis, tuberculosis, obesity, malaria, and illnesses due to viruses, such as HIV.Type: ApplicationFiled: February 6, 2003Publication date: August 12, 2004Applicant: Triton Biosystems, Inc.Inventors: Wolfgang Daum, Diane Ellis-Busby, Alan Foreman, Robert C. Goldstein, Douglas U. Gwost, Erik Schroeder Handy, Robert Ivkov, Valentin S. Nemkov
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Publication number: 20040156846Abstract: Methods for treating cells, diseased tissue, pathogens, or other undesirable matter involve the administration of a bioprobe (energy susceptive materials that are attached to the target-specific ligand chimeric L6 antibody) to a patient's body, body part, tissue, or body fluid (such as blood, blood plasma, or blood serum). An energy source provides energy to the bioprobe so as to destroy, rupture, or inactivate the target. Various energy forms, such as AMF, microwave, acoustic, or a combination thereof, created via a variety of mechanisms, may be used. The disclosed methods may be useful in the treatment of a variety of indications, including but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer.Type: ApplicationFiled: February 6, 2003Publication date: August 12, 2004Applicant: Triton Biosystems, Inc.Inventors: Wolfgang Daum, Gerald DeNardo, Diane Ellis-Busby, Alan Foreman, Douglas U. Gwost, Erik Schroeder Handy, Robert Ivkov
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Publication number: 20030032995Abstract: Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.Type: ApplicationFiled: July 19, 2002Publication date: February 13, 2003Applicant: Triton Biosystems, Inc.Inventors: Erik S. Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman, Susan J. Braunhut, Douglas U. Gwost, Blair Ardman
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Publication number: 20030028071Abstract: Disclosed are compositions comprising magnetic nanoparticles, a biocompatible coating, and a target-specific ligand. Also disclosed are devices for treating diseased tissue for use with such compositions. Further disclosed are methods for treating diseased tissue, such as cancer, using such compositions and devices, as well as methods for treating diseased tissue utilizing hypertermia.Type: ApplicationFiled: June 18, 2002Publication date: February 6, 2003Applicant: Triton Biosystems, Inc.Inventors: Erik Schroeder Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman