Patents by Inventor Diane J. Mathis

Diane J. Mathis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATION OF HOST IMMUNE CELL POPULATIONS USING GUT MICROBIOTA
    Publication number: 20200268813
    Abstract: Provided herein are methods of modulating selected populations of immune cells by administering specific bacterial strains to a subject. Also provided herein are methods of promoting expansion and/or contraction of selected populations of immune cells following the administration of a bacterial strain to a subject.
    Type: Application
    Filed: February 15, 2018
    Publication date: August 27, 2020
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Christophe O. BENOIST, Naama GEVA-ZATORSKY, Dennis KASPER, Diane J. MATHIS, Esen SEFIK
  • METHODS FOR TREATING RHEUMATOID ARTHRITIS
    Publication number: 20110165144
    Abstract: Provided are methods of treating rheumatoid arthritis by inhibiting Neuromedin U signalling.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 7, 2011
    Applicant: JOSLIN DIABETES CENTER, INC.
    Inventors: Bryce A. Binstadt, Diane J. Mathis, Christophe O. Benoist
  • REGULATORY T CELLS IN ADIPOSE TISSUE
    Publication number: 20110044939
    Abstract: Methods of preventing, delaying, or reducing the development or severity of obesity-associated disorders, including administering Fat-specific regulatory T cells, or administering factors secreted by said T cells.
    Type: Application
    Filed: June 27, 2008
    Publication date: February 24, 2011
    Applicant: JOSLIN DIABETES CENTER, INC.
    Inventors: Markus Feuerer, Diane J. Mathis, Steven Shoelson, Christophe O. Benoist
  • METHODS OF IMAGING INFLAMMATION IN PANCREATIC ISLETS
    Publication number: 20100166669
    Abstract: Described are non-invasive methods for imaging pancreatic inflammation in living mammals using Magnetic Nanoparticle Probes (MNPs).
    Type: Application
    Filed: June 28, 2006
    Publication date: July 1, 2010
    Applicants: JOSLIN DIABETES CENTER, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: Diane J. Mathis, Ralph Weissleder, Umar Mahmood, Christophe O. Benoist
  • Transgenic arthritic mice expressing a T-cell receptor transgene
    Patent number: 5675060
    Abstract: A transgenic animal model for arthritis is disclosed. The arthritic condition results from genetic (or immunologic) manipulations that result in the T cell receptor (TCR) repertoire of the animal being substantially limited relative to the TCR repertoire of a wildtype control animal. The TCR repertoire of the arthritic animal, albeit limited, is functionally viable. In a preferred embodiment, the invention relates to transgenic arthritic mice wherein arthritis results from (1) a transgenic allele which encodes and expresses TCR .alpha. and .beta. subunits that combine in T lymphocytes of the transgenic animal to form a TCR that recognizes an antigen comprising one or more epitopes of an oligopeptide derived from amino acids 41-61 of bovine pancreatic ribonuclease and/or (2) polypeptide arthritogenic self antigens derived from endogenous proteins.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: October 7, 1997
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, Strasbourg 1, E.R. Squibb & Sons, Inc.
    Inventors: Christophe O. Benoist, Diane J. Mathis, Valerie Kouskoff