Patents by Inventor Diane L. Bakaysa

Diane L. Bakaysa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Asp.sup.B1 insulin analogs
    Patent number: 5559094
    Abstract: Analogs of human insulin containing an aspartic acid at position 1 of the B chain (Asp.sup.B1), and optionally, having a gln modification at position 13 (Gln.sup.B13), display modified physico-chemical and pharmacokinetic properties which enable them to be long acting. These analogs are useful in the treatment of hyperglycemia because they are soluble and display an increased tendency to self-associate.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: September 24, 1996
    Assignee: Eli Lilly and Company
    Inventors: David N. Brems, Diane L. Bakaysa
  • Insulin analog formulations
    Patent number: 5474978
    Abstract: The present invention discloses a human insulin analog hexamer complex and formulations. More specifically, the present invention relates to various parenteral formulations, which comprise: human insulin analogs in a hexamer conformation, zinc ions, and at least three molecules of a phenolic derivative selected from the group consisting of m-cresol, phenol, or a mixture of m-cresol and phenol. The formulation provides a rapid onset of action.
    Type: Grant
    Filed: June 16, 1994
    Date of Patent: December 12, 1995
    Assignee: Eli Lilly and Company
    Inventors: Diane L. Bakaysa, David N. Brems, Bruce H. Frank, Henry A. Havel, Allen H. Pekar