Patents by Inventor Diane P. Copeland

Diane P. Copeland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE
    Publication number: 20210393590
    Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula 1 Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
    Type: Application
    Filed: September 3, 2021
    Publication date: December 23, 2021
    Inventors: Hanlan LIU, Chris WILLIS, Renu BHARDWAJ, Diane P. COPELAND, Abizer HARIANAWALA, Jeffrey SKELL, John MARSHALL, Jianmei KOCHLING, Gerard PALACE, Judith PETERSCHMITT, Craig SIEGEL, Seng CHENG
  • INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE
    Publication number: 20210369672
    Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
    Type: Application
    Filed: January 7, 2021
    Publication date: December 2, 2021
    Inventors: Hanlan LIU, Chris WILLIS, Renu BHARDWAJ, Diane P. COPELAND, Abizer HARIANAWALA, Jeffrey SKELL, John MARSHALL, Jianmei KOCHLING, Gerard PALACE, Judith PETERSCHMITT, Craig SIEGEL, Seng CHENG
  • INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
    Publication number: 20160166542
    Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
    Type: Application
    Filed: February 22, 2016
    Publication date: June 16, 2016
    Inventors: Hanlan Liu, Chris Willis, Renu Bhardwaj, Diane P. Copeland, Abizer Harianawala, Jeffrey Skell, John Marshall, Jianmei Kochling, Gerard Palace, Judith Peterschmitt, Craig Siegel, Seng Cheng
  • AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
    Publication number: 20160120842
    Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
    Type: Application
    Filed: January 13, 2016
    Publication date: May 5, 2016
    Inventors: Hanlan Liu, Chris Willis, Renu Bhardwaj, Diane P. Copeland, Abizer Harianawala, Jeffrey Skell, John Marshall, Jianmei Kochling, Gerard Palace, Judith Peterschmitt, Craig Siegel, Seng Cheng
  • AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
    Publication number: 20130137743
    Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
    Type: Application
    Filed: November 24, 2010
    Publication date: May 30, 2013
    Applicant: GENZYME CORPORATION
    Inventors: Hanlan Liu, Chris Willis, Renu Bhardwaj, Diane P. Copeland, Abizer Harianawala, Jeffrey Skell, John Marshall, Jianmei Kochling, Gerard Palace, Judith Peterschmitt, Craig Siegel, Seng Cheng
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20090312392
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: April 30, 2009
    Publication date: December 17, 2009
    Inventors: James A. Shayman, David J. Harris, Craig Siegel, Carol A. Nelson, Diane P. Copeland
  • Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
    Patent number: 7615573
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: November 10, 2009
    Assignees: The Regents of the University of Michigan, Genzyme Corporation
    Inventors: Craig Siegel, James A. Shayman, Carol A. Nelson, David J. Harris, Diane P. Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20080146533
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: July 27, 2007
    Publication date: June 19, 2008
    Inventors: James A. Shayman, David J. Harris, Craig Siegel, Carol A. Nelson, Diane P. Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 7253185
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: August 7, 2007
    Assignees: The Regents of the University of Michigan, Genzyme Corporation
    Inventors: James A. Shayman, David J. Harris, Craig Siegel, Carol A. Nelson, Diane P. Copeland
  • Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors
    Patent number: 7196205
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: March 27, 2007
    Assignees: The Regents of the University of Michigan, Genzyme Corporation
    Inventors: Craig Siegel, James A. Shayman, Carol A. Nelson, David J. Harris, Diane P. Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6916802
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: July 12, 2005
    Assignees: Genzyme Corporation, The Regents of the University of Michigan
    Inventors: James A. Shayman, David J. Harris, Craig Siegel, Carol A. Nelson, Diane P. Copeland