Abstract: Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

Abstract: Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

Abstract: A method comprising: providing a biological sample from a subject (subject sample); and detecting the expression level of each of the markers FGF-2 and CA125 in the subject sample. A kit comprising means for detection of an expression level of each of markers CA125 and FGF-2 in a biological sample from a subject (subject sample), and instructions to use said markers in a method of the present invention.

Abstract: The present invention concerns a method of prognosing the risk of early ovarian cancer relapse in a subject having ovarian cancer comprising: a) detecting the level of at least one marker selected from the group consisting of BTF4, GCS and HLA-DRbeta1; and b) comparing the level of the above at least one marker with that of a corresponding control sample, wherein the detection of a lower level of the at least one marker compared to that in the control sample is indicative that the subject is at risk of early cancer relapse. Also provided is a method of stratifying a subject suffering from ovarian cancer based on the expression levels of the disclosed markers and kits for practicing the methods of the present invention.

Abstract: A method for the diagnosis of ovarian cancer comprising providing a biological sample from a subject (subject sample), and detecting the expression level of each of the markers FGF-2, CA 125 and IL-18 in the subject sample A kit comprising means for detection of an expression level of each of the markers CA 125, FGF-2 and IL-18 in a biological sample from a subject (subject sample), and instructions to use said markers in a method of the present invention.

Abstract: The present invention relates to primary cultures or established cell lines of ovarian epithelium origin which are substantially equivalent to the cells from the original clinical material from which they are derived and can serve as a powerful model in numerous types of studies including the elaboration of a patient-based tumor profile, thereby permitting a more precise and personalized design of an efficacious therapeutic regimen for cancer therapy. The invention further relates to a method to derive primary cell cultures from benign and malignant ovarian tissue and from ascites.