Patents by Inventor Diane Simeone

Diane Simeone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Using C-Met Modulators
    Publication number: 20150202196
    Abstract: Disclosed are methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt thereof, in combination with gemcitabine (GEM), or a pharmaceutically acceptable salt thereof, and optionally one or more additional treatments, wherein: R1 is halo; R2 is halo; R3 is (C1-C6)alkyl; R4 is (C1-C6)alkyl; and Q is CH or N.
    Type: Application
    Filed: October 20, 2014
    Publication date: July 23, 2015
    Inventors: Lynne Canne Bannen, Diva Sze-Ming Chan, Timothy Patrick Forsyth, Richard George Khoury, James William Leahy, Morrison B. Mac, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Yong Wang, Wei Xu, Diane Simeone
  • Multimodal spectroscopic systems and methods for classifying biological tissue
    Patent number: 8694266
    Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: April 8, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Mary-Ann Mycek, Malavika Chandra, James Scheiman, Robert H. Wilson, Diane Simeone, Barbara McKenna, Jeremy Taylor, Oliver Lee, Leng-Chun Chen, William Lloyd
  • Methods for Diagnosing The Malignant Potential of Pancreatic Cystic Lesions
    Publication number: 20130005598
    Abstract: A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, determining whether the glycan alteration is differentially present in the sample, and diagnosing the malignant potential of the pancreatic cystic lesion. A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: (a) detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, (b) detecting CA 19-9 in the sample, (c) determining whether the glycan alteration and CA 19-9 are differentially present in the sample, and (d) diagnosing the malignant potential of the pancreatic cystic lesion. Related methods of treatment and kits also are included.
    Type: Application
    Filed: December 30, 2010
    Publication date: January 3, 2013
    Applicants: The Regents of the University of Michigan, Van Andel Research Institute
    Inventors: Brian B. Haab, Diane Simeone
  • MULTIMODAL SPECTROSCOPIC SYSTEMS AND METHODS FOR CLASSIFYING BIOLOGICAL TISSUE
    Publication number: 20120245473
    Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes.
    Type: Application
    Filed: May 16, 2012
    Publication date: September 27, 2012
    Inventors: Mary-Ann Mycek, Malavika Chandra, James Scheiman, Robert H. Wilson, Diane Simeone, Barbara McKenna, Jeremy Taylor, Oliver Lee, Leng-Chun Chen, William Lloyd
  • Multimodal spectroscopic systems and methods for classifying biological tissue
    Patent number: 8239139
    Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with preset criteria configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: August 7, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Mary-Ann Mycek, Malavika Chandra, James Scheiman, Robert H. Wilson, Diane Simeone, Barbara McKenna, Julianne Purdy
  • Multimodal spectroscopic systems and methods for classifying biological tissue
    Patent number: 8234078
    Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: July 31, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Mary-Ann Mycek, Malavika Chandra, James Scheiman, Robert H. Wilson, Diane Simeone, Barbara McKenna, Julianne Purdy, Jeremy Taylor, Oliver Lee
  • Methods of Using C-Met Modulators
    Publication number: 20120070368
    Abstract: Disclosed are methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt thereof, in combination with gemcitabine (GEM), or a pharmaceutically acceptable salt thereof, and optionally one or more additional treatments, wherein: R1 is halo; R2 is halo; R3 is (C1-C6)alkyl; R4 is (C1-C6)alkyl; and Q is CH or N.
    Type: Application
    Filed: April 14, 2011
    Publication date: March 22, 2012
    Applicant: Exelixis, Inc.
    Inventors: Lynne Canne Bannen, Diva Sze-Ming Chan, Timothy Patrick Forsyth, Richard George Khoury, James William Leahy, Morrison B. Mac, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Yong Wang, Wei Xu, Diane Simeone
  • Compositions and methods for treating cancer
    Patent number: 8088749
    Abstract: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target ATDC (TRIM29) expression in cancer with ATDC overexpression.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: January 3, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Diane Simeone, Mats Ljungman, Liang Xu, Lidong Wang, Fengtian He
  • Multimodal Spectroscopic Systems and Methods for Classifying Biological Tissue
    Publication number: 20100330611
    Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.
    Type: Application
    Filed: September 14, 2010
    Publication date: December 30, 2010
    Applicant: The Regents of the University of Michigan
    Inventors: Mary-Ann Mycek, Malavika Chandra, James Scheiman, Robert H. Wilson, Diane Simeone, Barbara McKenna, Julianne Purdy, Jeremy Taylor, Oliver Lee
  • Multimodal Spectroscopic Systems and Methods for Classifying Biological Tissue
    Publication number: 20090317856
    Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with preset criteria configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 24, 2009
    Inventors: Mary-Ann Mycek, Malavika Chandra, James Scheiman, Robert H. Wilson, Diane Simeone, Barbara McKenna, Julianne Purdy
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20090192112
    Abstract: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target ATDC (TRIM29) expression in cancer with ATDC overexpression.
    Type: Application
    Filed: December 12, 2008
    Publication date: July 30, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Diane Simeone, Mats Ljungman, Liang Xu, Lidong Wang
  • Expression profile of pancreatic cancer
    Publication number: 20050009067
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with pancreatic cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of pancreatic cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
    Type: Application
    Filed: May 18, 2004
    Publication date: January 13, 2005
    Inventors: Craig Logsdon, Samir Hanash, Diane Simeone