Patents by Inventor Diane Trainor
Diane Trainor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5622964Abstract: Methods of treating asthma are provided which methods comprise administering to a mammal in need of such treatment an effective amount of a compound of Formula I ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.2, R.sup.3, R.sup.4, R.sup.10 and R.sup.11 have any of the meanings given in the specification.Type: GrantFiled: August 18, 1995Date of Patent: April 22, 1997Assignee: Zeneca LimitedInventors: Cyrus J. Ohnmacht, Jr., Diane A. Trainor, Janet M. Forst, Mark M. Stein, Robert J. Harris
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Patent number: 5550136Abstract: Compounds of formula I ##STR1## wherein X and Y are H or halo; R.sup.2 is: [structures Ia, Ib or Ic;] ##STR2## R.sup.3 is selected from unsubstituted or substituted alkyl, aryl or heteroaryl groups;R.sup.4 is selected from H or (C1-6)alkyl,and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disoders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropschiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective mount of a compound of formula I, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 19, 1995Date of Patent: August 27, 1996Assignee: Zeneca LimitedInventors: Robert T. Jacobs, Cyrus J. Ohnmacht, Diane A. Trainor
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Patent number: 5484792Abstract: Compounds of general formula I, ##STR1## and pharmaceutically acceptable salts thereof, in which R.sup.1 has any of the meanings given in the specification, pharmaceutical compositions comprising them and their use in the treatment of urinary incontinence.Type: GrantFiled: February 8, 1994Date of Patent: January 16, 1996Assignee: Imperial Chemical Industries, plcInventors: Cyrus J. Ohnmacht, Robert J. Harris, Diane A. Trainor
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Patent number: 5482969Abstract: Compounds of formula I: ##STR1## wherein, ring C, A-B, R.sup.1, n, R.sup.2, and R.sup.3 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinary incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: March 11, 1994Date of Patent: January 9, 1996Assignee: Zeneca LimitedInventors: James R. Empfield, Cyrus J. Ohnmacht, Keith Russell, Diane A. Trainor, Paul J. Warwick, Jr.
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Patent number: 5455246Abstract: Compounds of formula I, Ia or Ib and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disorders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropschiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 13, 1993Date of Patent: October 3, 1995Assignee: Imperial Chemical Industries, plcInventors: Ying K. Yee, Cyrus J. Ohnmacht, Diane A. Trainor, Joseph J. Lewis
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Patent number: 5455253Abstract: Compounds of formula I ##STR1## wherein R.sup.2, R.sup.3, R.sup.4, R.sup.10 and R.sup.11 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinery incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: April 14, 1994Date of Patent: October 3, 1995Assignee: Zeneca LimitedInventors: Cyrus J. Ohnmacht, Jr., Diane Trainor, Janet M. Forst, Mark M. Stein, Robert J. Harris
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Patent number: 5414132Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.Type: GrantFiled: September 4, 1992Date of Patent: May 9, 1995Assignee: Zeneca Inc.Inventors: Mark M. Stein, Diane A. Trainor
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Patent number: 5399568Abstract: Compounds of formula I ##STR1## wherein X and Y are H or halo; R.sup.2 is: [structures Ia, Ib or Ic;] ##STR2## R.sup.3 is selected from unsubstituted or substituted alkyl, aryl or heteroaryl groups;R.sup.4 is selected from H or (Cl-6)alkyl,and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disoders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropschiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 6, 1992Date of Patent: March 21, 1995Assignee: Imperial Chemical Industries plcInventors: Robert T. Jacobs, Cyrus J. Ohnmacht, Diane A. Trainor
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Patent number: 5340819Abstract: Compounds of general formula I, ##STR1## and pharmaceutically acceptable salts thereof, in which R.sup.1 has any of the meanings given in the specification, pharmaceutical compositions comprising them and their use in the treatment of urinary incontinence.Type: GrantFiled: October 20, 1992Date of Patent: August 23, 1994Assignee: Imperial Chemical Industries plcInventors: Cyrus J. Ohnmacht, Robert J. Harris, Diane A. Trainor
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Patent number: 5266570Abstract: Compounds of formula I, Ia or Ib and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disorders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropschiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof; ##STR1##Type: GrantFiled: August 6, 1992Date of Patent: November 30, 1993Assignee: Imperial Chemical Industries PLCInventors: Ying K. Yee, Cyrus J. Ohnmacht, Diane A. Trainor, Joseph J. Lewis
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Patent number: 5194588Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.Type: GrantFiled: March 9, 1990Date of Patent: March 16, 1993Assignee: ICI Americas Inc.Inventors: Philip D. Edwards, John A. Schwartz, Mark M. Stein, Diane A. Trainor, Richard A. Wildonger
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Patent number: 5164371Abstract: The invention provides a series of novel heterocyclic ketones of formula I ##STR1## and pharmaceutically acceptable base-addition salts thereof, in which the values of R.sup.4, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I.Type: GrantFiled: May 11, 1988Date of Patent: November 17, 1992Assignee: ICI Americas Inc.Inventors: Philip D. Edwards, Joseph J. Lewis, Charles W. Perkins, Diane A. Trainor, Richard A. Wildonger
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Patent number: 5055450Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.Type: GrantFiled: March 13, 1990Date of Patent: October 8, 1991Assignee: ICI Americas Inc.Inventors: Philip D. Edwards, John A. Schwartz, Mark M. Stein, Diane A. Trainor, Richard A. Wildonger
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Patent number: 4923890Abstract: The invention relates to selected difluoro compounds of formulae Ia, Ib and Ic (set out hereinafter) which are useful as inhibitors of human leukocyte elastase.Type: GrantFiled: May 19, 1987Date of Patent: May 8, 1990Assignee: ICI Americas Inc.Inventors: Diane A. Trainor, Mark M. Stein
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Patent number: 4910190Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.Type: GrantFiled: January 20, 1987Date of Patent: March 20, 1990Assignee: ICI Americas Inc.Inventors: Scott H. Bergeson, Philip D. Edwards, John A. Schwartz, Andrew Shaw, Mark M. Stein, Diane A. Trainor, Richard A. Wildonger, Donald J. Wolanin
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Patent number: 4880780Abstract: The invention discloses a series of difluoroketone, mono- di- and tri-peptide derivatives of formula Ia, Ib and Ic:______________________________________ (Formula set out on pages following Examples) Ia (Formula set out on pages following Examples) Ib (Formula set out on pages following Examples) Ic ______________________________________and salts thereof where appropriate, and wherein the radicals are defined hereafter in the specification. The derivatives are useful in inhibiting the action of human leukocyte elastase. There are also disclosed methods and intermediates for the manufacture of, and pharmaceutical compositions comprising, the said derivatives.Type: GrantFiled: June 4, 1987Date of Patent: November 14, 1989Assignee: ICI Americas Inc.Inventors: Diane A. Trainor, Mark M. Stein
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Patent number: 4873221Abstract: The invention relates to selected difluoro compounds of formulae Ia, Ib and Ic ( set out hereinafter) which are useful as inhibitors of human leukocyte elastase.Type: GrantFiled: May 19, 1987Date of Patent: October 10, 1989Assignee: ICI Americas Inc.Inventor: Diane A. Trainor
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Patent number: 4691007Abstract: Proline derivatives of the formulae: ##STR1## wherein R.sup.1 through R.sup.11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.Type: GrantFiled: December 6, 1985Date of Patent: September 1, 1987Assignees: ICI Americas Inc., Imperial Chemical Industries PLCInventors: Anand S. Dutta, Ross L. Stein, Diane A. Trainor, Richard A. Wildonger
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Patent number: 4596789Abstract: Proline derivatives of the formulae: ##STR1## wherein R.sup.1 through R.sup.11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.Type: GrantFiled: April 24, 1984Date of Patent: June 24, 1986Assignees: ICI Americas Inc., Imperial Chemical Industries PLCInventors: Anand S. Dutta, Ross L. Stein, Diane A. Trainor, Richard A. Wildonger