Abstract: A cap or closure for a pharmaceutical vial includes a fill hole to permit filling of the vial with the cap in place. In one form the vial and cap assembly comprises an open-top vial covered by a cap having a depending peripheral skirt. The inner surface of the cap skirt and the outer surface of the vial are provided with complementary mating interlock elements that preclude manual removal of the cap. The cap includes an integral tear member, defined by one or more weakened, partially circumferential weakened junction lines, such that pulling away the tear member along the junction line allows both manual removal of the cap and ready visual confirmation that vial integrity has been breached. The cap includes a fill hole permitting the filling of the vial with the cap in place. The fill hole is closed, after filling, by a resilient stopper having a configuration effectively precluding its manual removal, so that post-filling tampering and contamination are precluded.