Patents by Inventor Dianna Maar

Dianna Maar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200270677
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Application
    Filed: March 30, 2020
    Publication date: August 27, 2020
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: John F. REGAN, Dianna MAAR, Dawne N. SHELTON, Tina C. LEGLER, Samantha COOPER, Wei YANG, Eli A. HEFNER, Niels KLITGORD
  • Patent number: 10718008
    Abstract: Methods of detecting or quantifying short RNA or DNA molecules using split cycle amplification are provided.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: July 21, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Dianna Maar, Samantha Cooper, Wei Yang
  • Patent number: 10604789
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: March 31, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John F. Regan, Dianna Maar, Dawne N. Shelton, Tina C. Legler, Samantha Cooper, Wei Yang, Eli A. Hefner, Niels Klitgord
  • Publication number: 20190211388
    Abstract: Methods and compositions are provided for improved nucleic acid amplification assays. In some embodiments, the nucleic acid amplification assay is a tagged amplicon primer extension (TAPE) nucleic acid amplification reaction.
    Type: Application
    Filed: March 22, 2019
    Publication date: July 11, 2019
    Inventors: Nicholas HEREDIA, Dianna MAAR
  • Publication number: 20190161793
    Abstract: Methods of detecting or quantifying short RNA or DNA molecules using split cycle amplification are provided.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 30, 2019
    Inventors: Dianna MAAR, Samantha COOPER, Wei YANG
  • Patent number: 10280455
    Abstract: Methods and compositions are provided for improved nucleic acid amplification assays.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: May 7, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Nicholas Heredia, Dianna Maar
  • Publication number: 20190119736
    Abstract: Methods of, and compositions for, analysis using digital amplification assays with unconventional/inverse changes in photoluminescence to indicate the presence of one or more targets. In an exemplary method, isolated volumes may be formed, only a subset of which contain a target. Each volume may include a probe having a label, a sink having a quencher and configured to hybridize with the probe to quench the label, and a separator configured to hybridize with the probe and/or the sink to block hybridization of the sink with the probe. An amplification reaction may be performed in the volumes to generate an amplicon corresponding to the target. The separator may hybridize with the amplicon, and may be extended or degraded by the amplification reaction. Photoluminescence of the label may be detected from the volumes, and the photoluminescence of target-positive volumes may be less than that of target-negative volumes.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 25, 2019
    Inventors: Eli A. HEFNER, Dianna MAAR
  • Publication number: 20180363041
    Abstract: Methods and compositions for detecting genetic instability using digital amplification assays. The methods may be performed in a set of isolated volumes and generally may involve competitive hybridization of a competitor and a probe/primer with a normal allele and one or more mutant alleles of a microsatellite locus. The competitor may be configured to compete similarly with, or to outcompete, the primer/probe for hybridization with the normal allele. The primer/probe may be configured to outcompete the competitor for hybridization with various mutant alleles of the locus that alter the length of the repetitive sequence by different amounts. Isolated volumes in which the primer/probe outcompetes the competitor may be enumerated, and represent one or more of the mutant alleles. The methods may enable diagnosing microsatellite instability and treating a subject based on the diagnosis.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 20, 2018
    Inventor: Dianna Maar
  • Publication number: 20180251817
    Abstract: Digital assay system, including methods, apparatus, and compositions, for assay of one or more targets in a set of partitions containing a generic reporter of target amplification.
    Type: Application
    Filed: May 7, 2018
    Publication date: September 6, 2018
    Inventors: Duc DO, Claudia LITTERST, Dianna MAAR
  • Patent number: 9970052
    Abstract: Digital assay system, including methods, apparatus, and compositions, for assay of one or more targets in a set of partitions containing a generic reporter of target amplification.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: May 15, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Duc Do, Claudia Litterst, Dianna Maar
  • Patent number: 9845496
    Abstract: Digital assay system, including methods, apparatus, and compositions, for performing target assays in partitions each containing a generic reporter and a specific reporter for target amplification.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: December 19, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John F. Regan, Svilen S. Tzonev, Yann Jouvenot, Claudia Litterst, Dianna Maar, Geoff McDermott
  • Publication number: 20170191124
    Abstract: Methods and compositions are provided for improved nucleic acid amplification assays.
    Type: Application
    Filed: December 28, 2016
    Publication date: July 6, 2017
    Inventors: Nicholas Heredia, Dianna Maar
  • Publication number: 20170166957
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Application
    Filed: January 20, 2017
    Publication date: June 15, 2017
    Inventors: John F. Regan, Dianna Maar, Dawne N. Shelton, Tina C. Legler, Samantha Cooper, Wei Yang, Eli A. Hefner, Niels Klitgord
  • Patent number: 9556475
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: January 31, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John F. Regan, Dianna Maar, Dawne N. Shelton, Tina C. Legler, Samantha Cooper, Wei Yang, Eli A. Hefner, Niels Klitgord
  • Publication number: 20160265041
    Abstract: Methods of detecting or quantifying short RNA or DNA molecules using split cycle amplification are provided.
    Type: Application
    Filed: February 17, 2016
    Publication date: September 15, 2016
    Inventors: Dianna MAAR, Samantha COOPER, Wei YANG
  • Publication number: 20160102346
    Abstract: Digital assay system, including methods, apparatus, and compositions, for performing target assays in partitions each containing a generic reporter and a specific reporter for target amplification.
    Type: Application
    Filed: December 21, 2015
    Publication date: April 14, 2016
    Inventors: John F. Regan, Svilen S. Tzonev, Yann Jouvenot, Claudia Litterst, Dianna Maar, Geoff McDermott
  • Patent number: 9217175
    Abstract: Digital assay system, including methods, apparatus, and compositions, for performing target assays in partitions each containing a generic reporter and a specific reporter for target amplification.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: December 22, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John F. Regan, Svilen S. Tzonev, Yann Jouvenot, Claudia Litterst, Dianna Maar, Geoff McDermott
  • Publication number: 20150148250
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Application
    Filed: August 12, 2014
    Publication date: May 28, 2015
    Inventors: John F. Regan, Dianna Maar, Dawne N. Shelton, Tina C. Legler, Samantha Cooper, Wei Yang, Eli A. Hefner, Niels Klitgord
  • Publication number: 20140221238
    Abstract: Digital assay system, including methods, apparatus, and compositions, for performing target assays in partitions each containing a generic reporter and a specific reporter for target amplification.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Inventors: John F. Regan, Svilen S. Tzonev, Yann Jouvenot, Claudia Litterst, Dianna Maar, Geoff McDermott
  • Publication number: 20140178889
    Abstract: Digital assay system, including methods, apparatus, and compositions, for assay of one or more targets in a set of partitions containing a generic reporter of target amplification.
    Type: Application
    Filed: February 26, 2014
    Publication date: June 26, 2014
    Inventors: Duc Do, Claudia Litterst, Dianna Maar