Patents by Inventor Dianne DANIELS ELMAKIAS

Dianne DANIELS ELMAKIAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240100326
    Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.
    Type: Application
    Filed: November 30, 2023
    Publication date: March 28, 2024
    Inventors: Yael MARDOR, Shirley SHARABI, Itzik COOPER, David LAST, David GUEZ, Dianne DANIELS ELMAKIAS, Yael BRESLER
  • Patent number: 11931569
    Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: March 19, 2024
    Assignee: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE & SERVICES LTD.
    Inventors: Yael Mardor, Shirley Sharabi, Itzik Cooper, David Last, David Guez, Dianne Daniels Elmakias, Yael Bresler
  • Patent number: 11933866
    Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: March 19, 2024
    Assignees: Tel Hashomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels Elmakias
  • Patent number: 11892530
    Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: February 6, 2024
    Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels Elmakias
  • Publication number: 20240029249
    Abstract: A method of analyzing CT data comprises receiving data describing a pre-contrast administration CT scan from a body region of the subject, and a post-contrast administration CT scan acquired from the body region at least 1 minute after initiation of administration of a contrast agent to the subject. A subtraction map is formed by subtracting one of the scans from another. The subtraction map is displayed in a manner that identifies leaking of contrast agent out of blood vessels in the region.
    Type: Application
    Filed: October 4, 2023
    Publication date: January 25, 2024
    Applicant: Sheba Impact Ltd.
    Inventors: Yael MARDOR, David LAST, Dianne DANIELS ELMAKIAS, Shirley SHARABI, Jair BAR, Nadav FORIE, Liran LEVY, Edith Michelle MAROM
  • Patent number: 10970594
    Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: April 6, 2021
    Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Leor Zach, David Guez, David Last, Dianne Daniels Elmakias, Yael Mardor, Shirley Sharabi, Noam Nissan, Miriam Sklair-Levy
  • Publication number: 20210016084
    Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.
    Type: Application
    Filed: March 12, 2019
    Publication date: January 21, 2021
    Inventors: Yael MARDOR, Shirley SHARABI, Itzik COOPER, David LAST, David Guez, Dianne DANIELS ELMAKIAS, Yael BRESLER
  • Publication number: 20200371174
    Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
    Type: Application
    Filed: August 13, 2020
    Publication date: November 26, 2020
    Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yael MARDOR, Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS
  • Publication number: 20200371173
    Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
    Type: Application
    Filed: August 13, 2020
    Publication date: November 26, 2020
    Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yael MARDOR, Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS
  • Publication number: 20190180139
    Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 13, 2019
    Applicants: Tel HaShomer Medical Research Infrastructure and S ervices Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS, Yael MARDOR