Patents by Inventor Dianne Schwarz

Dianne Schwarz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING
    Publication number: 20100184827
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: March 29, 2010
    Publication date: July 22, 2010
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. ZAMORE, Gyorgy HUTVAGNER, Dianne SCHWARZ, Martin SIMARD
  • Methods and compositions for enhancing the efficacy and specificity of RNA silencing
    Patent number: 7750144
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: July 6, 2010
    Assignee: University of Massachusetts
    Inventors: Phillip D. Zamore, György Hutvágner, Dianne Schwarz, Martin Simard
  • Compositions and methods for enhancing discriminatory RNA interference
    Publication number: 20070259827
    Abstract: The present invention provides methods for enhancing discriminatory RNA silencing by RNA silencing agents. In particular, the invention provides methods for generating RNA silencing agents which can discriminate between target and non-target mRNAs that differ in sequence by only one nucleotide. Also provided are improved RNA silencing agents with enhanced discriminatory RNA silencing, e.g., single nucleotide discriminatory RNA silencing. The compositions and methods of the invention are useful in therapeutic strategies for treating genetic disorders associated with dominant, gain-of-function gene mutations.
    Type: Application
    Filed: January 25, 2007
    Publication date: November 8, 2007
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Neil Aronin, Dianne Schwarz, Phillip Zamore
  • Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
    Publication number: 20060134787
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: December 22, 2004
    Publication date: June 22, 2006
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip Zamore, Dianne Schwarz
  • Methods and compositions for enhancing the efficacy and specificity of RNAi
    Publication number: 20050186586
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: August 4, 2004
    Publication date: August 25, 2005
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip Zamore, Gyorgy Hutvagner, Dianne Schwarz, Martin Simard
  • Methods and compositions for enhancing the efficacy and specificity of RNAi
    Publication number: 20050181382
    Abstract: The present invention provides methods of enhancing the efficacy and specificity of RNAi. The invention also provides compositions for mediating RNAi. In particular, the invention provides siRNAs, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
    Type: Application
    Filed: June 2, 2004
    Publication date: August 18, 2005
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip Zamore, Gyorgy Hutvagner, Dianne Schwarz, Martin Simard
  • Compositions for RNA interference and methods of use thereof
    Publication number: 20040203145
    Abstract: The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides single-stranded small interfering RNAs. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.
    Type: Application
    Filed: August 7, 2003
    Publication date: October 14, 2004
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Phillip D. Zamore, Gyorgy Hutvagner, Dianne Schwarz, Guiliang Tang, Benjamin Haley