Abstract: A Wasserstein distance and difference metric-combined chest radiograph anomaly identification domain adaptation method and a corresponding system are provided. The method includes the following steps: step 1, data preparation and data pre-processing for chest radiographs; step 2, multi-scale feature extraction based on a swin transformer network; step 3, loss minimization based on a Wasserstein distance and a contrastive domain discrepancy; and step 4, using the model to perform chest radiograph prediction after verifying the model. The method selects source domain samples closest to target domain samples, narrows a distance of the same class between the target domain samples and the source domain samples in feature space, and expands a distance between different classes. Meanwhile, a classification prediction task for the chest radiographs is performed by using the multi-scale features, improving a receptive field and capturing more information conducive to the classification prediction task.

Abstract: The disclosure relates to novel compounds that include one or more aromatic boron-containing groups and methods of making the disclosed compounds. The present disclosure further relates to pharmaceutical compositions comprising the disclosed compounds, and their use in prevention and treatment of diseases and disorders.

Abstract: Embodiments of the present disclosure relate to sensors that can selectively bind to specific vicinal diols in the presence of other diols. These boronated vicinal diol-responsive sensor compounds can sense levels of specific vicinal diols and respond to these molecules in the body. In certain embodiments, the vicinal diol is a cis diol, for example, a hexose such as glucose. In certain embodiments the sensors are conjugated to a drug substance, and the sensors may change the biophysical characteristics, pharmacokinetics, and/or activity of the drug substance in response to the vicinal diol. The drug substance may be or include a polypeptide, such as an insulin, a human endocrine or incretin peptide, or an analogue thereof, and may contain one or more modified amino acids containing a vicinal diol-responsive sensor.