Patents by Inventor Dick Schipper
Dick Schipper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9115378Abstract: The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism.Type: GrantFiled: October 17, 2012Date of Patent: August 25, 2015Assignee: DSM IP ASSETS B.V.Inventors: Marie-Gabrielle Beuzelin-Ollivier, Bastien Chevreux, Manuela Dalluege, Marina Van Gelder, Markus G. Goese, Corina Hauk, Bertus P. Koekman, Connie Lee, Anne F. Mayer, Anja Meury, Nigel J. Mouncey, Dick Schipper, Masako Shinjoh, Christine Toepfer, Adrianus W. H. Vollebregt
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Patent number: 8945898Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: GrantFiled: July 1, 2011Date of Patent: February 3, 2015Assignee: DSM IP Assets B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
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Publication number: 20130144034Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: ApplicationFiled: July 1, 2011Publication date: June 6, 2013Applicant: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
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Patent number: 8318462Abstract: The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism.Type: GrantFiled: August 1, 2007Date of Patent: November 27, 2012Assignee: DSM IP Assets B.V.Inventors: Marie-Gabrielle Beuzelin-Ollivier, Bastian Chevreux, Manuela Dalluege, Marina Van Gelder, Markus G. Goese, Corina Hauk, Bertus P. Koekman, Connie Lee, Anne F. Mayer, Anja Meury, Nigel J. Mouncey, Dick Schipper, Masako Shinjoh, Christine Toepfer, Adrianus W. H. Vollebregt
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Publication number: 20100248315Abstract: The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism.Type: ApplicationFiled: August 1, 2007Publication date: September 30, 2010Inventors: Marie-Gabrielle Beuzelin-Ollivier, Bastian Chevreux, Manuela Dalluegge, Marina Van Gelder, Markus G. Goese, Corina Hauk, Bertus P. Koekman, Connie Lee, Anne F. Mayer, Anja Meury, Nigel J. Mouncey, Dick Schipper, Masako Shinjoh, Christine Toepfer, Adrianus W.H. Vollebregt
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Patent number: 6803460Abstract: A method for the recovery of an N-substituted cephalosporanic acid compound of general formula (I), wherein R2 is selected from the group consisting of adipyl (1,4-dicarboxybutane), succinyl, glutaryl, adipyl, pimelyl, suberyl, 2-carboxyethyithio)acetyl, 3-carboxyethylthio)propionyl, higher alkyl saturated and higher alkyl unsaturated dicarboxylic acids, from a complex mixture comprising in addition to the compound of general formula (I) 6-aminopenicillanic acid (6-APA) and optionally one or more N-substituted penicillanic acid compounds, comprising the steps of: (a) acidifying the complex mixture to a pH below 6.5 and maintaining the mixture below said pH at a temperature of between 10° C. and 150° C.; and/or (b) contacting the complex mixture with a carbon dioxide source; and (c) recovering the cephalosporanic acid compound of formula (I) from the mixture obtained after steps (a) and/or (b).Type: GrantFiled: September 24, 2002Date of Patent: October 12, 2004Assignee: DSM IP Assets B.V.Inventors: Ilco Adrainus Lambertus Antonius Boogers, Emilius Johannes Albertus Xaverius Van De Sandt, Dick Schipper
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Publication number: 20030139595Abstract: A method for the recovery of an N-substituted cephalosporanic acid compound of general formula (I), wherein R2 is selected from the group consisting of adipyl (1,4-dicarboxybutane), succinyl, glutaryl adipyl, pimelyl, suberyl, 2-carboxyethyithio)acetyl, 3-carboxyethylthio)propionyl, higher alkyl saturated and higher alkyl unsaturated dicarboxylic acids, from a complex mixture comprising in addition to the compound of general formula (I) 6-aminopenicillanic acid (6-APA) and optionally one or more N-substituted penicillanic acid compounds, comprising the steps of: (a) acidifying the complex mixture to a pH below 6.5 and maintaining the mixture below said pH at a temperature of between 10° C. and 150° C.; and/or (b) contacting the complex mixture with a carbon dioxide source; and (c) recovering the cephalosporanic acid compound of formula (I) from the mixture obtained after steps (a) and/or (b).Type: ApplicationFiled: September 24, 2002Publication date: July 24, 2003Inventors: Ilco Adrianus Lambertus Antonius Boogers, Emilius Johannes Albertus Xaverius Van De Sandt, Dick Schipper
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Patent number: 6552185Abstract: A method for the recovery of a compound formula (I) from a complex mixture, comprising the steps of: (a) acidifying the complex mixture to a pH below 6.5 and maintaining the mixture below said pH at a temperature of between 50° C. and 130° C.; and/or (b) contacting the complex mixture with a carbon dioxide source; and (c) subjecting the mixture obtained after steps (a) and/or (b) to chromatography to obtain the compound of formula (I).Type: GrantFiled: November 16, 2000Date of Patent: April 22, 2003Assignee: DSM N.V.Inventors: Ilco Adrianus Lambertus Antonius Boogers, Emilius Johannes Albertus Xaverius Van De Sandt, Dick Schipper