Patents by Inventor Diderik Reinder Kremer
Diderik Reinder Kremer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140187749Abstract: The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate and polishing step comprises in-line anion exchange chromatography (AEX) treatment and mixed mode chromatography (MiMo) treatment in flow through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a mixed mode chromatography part, which are serially connected, wherein the unit comprises an inlet at the upstream end of the anion exchange chromatography part and an outlet at the downstream end of the mixed mode chromatography part and wherein the unit also comprises an inlet between the anion exchange chromatography part and the mixed mode chromatography part.Type: ApplicationFiled: June 8, 2012Publication date: July 3, 2014Applicant: DSM IP ASSETS B.V.Inventors: Maria Perlasca Islas, Diderik Reinder Kremer, Mark K. Doeven, Henderik E. Veenstra
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Publication number: 20130289247Abstract: The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate and polishing step comprises in either order in-line anion exchange chromatography (AEX) chromatography and cation exchange chromatography (CEX) chromatography steps in flow-through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a cation exchange chromatography part in either order, which are serially connected, wherein the unit comprises an inlet at the upstream end of the first ion exchange chromatography part and an outlet at the downstream end of the second ion exchange chromatography part and wherein the unit also comprises an inlet between the first ion exchange chromatography part and the second ion exchange chromatography part.Type: ApplicationFiled: October 13, 2011Publication date: October 31, 2013Applicant: DSM IP ASSETS B.V.Inventors: Diderik Reinder Kremer, Marijke Yvonne Dorst
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Patent number: 8501255Abstract: The invention pertains to a particulate composition comprising calcium lactate and calcium citrate microparticles having an average diameter from 0.1 ?m to 20 ?m, wherein the composition is in the form of particles with an average diameter from 25 ?m to 1 ?m, wherein the ratio by weight of calcium lactate to calcium citrate, based on the dry weight, is 80:20 to 30:70 , and wherein the calcium lactate is a non-polymeric agglomeration agent for the calcium citrate microparticles. The invention further relates to a process for producing the particulate composition wherein an aqueous solution of calcium lactate comprising calcium citrate microparticles is spray-dried to the particulate composition, to the use of the particulate composition as calcium-enhancer, and to alimentary products.Type: GrantFiled: December 10, 2007Date of Patent: August 6, 2013Assignee: Purac Biochem B.V.Inventors: Diderik Reinder Kremer, Jildert Eelke Visser, Marcus Johannes Anthonium Wilhelmus Vorage
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Publication number: 20130131318Abstract: The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate purification and polishing step comprises in-line anion exchange chromatography (AEX) treatment and hydrophobic interaction chromatography (HIC) treatment in flow through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a hydrophobic interaction chromatography part, which are serially connected, wherein the unit comprises an inlet at the upstream end of the anion exchange chromatography part and an outlet at the downstream end of the hydrophobic interaction chromatography part and wherein the unit also comprises an inlet between the anion exchange chromatography part and the hydrophobic interaction chromatography part.Type: ApplicationFiled: February 10, 2011Publication date: May 23, 2013Inventors: Diderik Reinder Kremer, Randal William Maarleveld
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Patent number: 8329638Abstract: An antibacterial composition includes a combination of fatty acid ester of fatty acid and hydroxy carboxylic acid with an antibacterial agent selected from polylysine, chitosan, protamine, their salts and mixtures hereof. The hydroxy carboxylic acid may be present as acid in its free form, in its salt form and/or in its ester form. The composition may be used as an antibacterial agent against gram-negative bacteria in various products, applications and methods.Type: GrantFiled: May 24, 2011Date of Patent: December 11, 2012Assignee: Purac Biochem B.V.Inventors: Roel Otto, Aldana Mariel Ramirez, Diderik Reinder Kremer
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Publication number: 20110230395Abstract: An antibacterial composition includes a combination of fatty acid ester of fatty acid and hydroxy carboxylic acid with an antibacterial agent selected from polylysine, chitosan, protamine, their salts and mixtures hereof. The hydroxy carboxylic acid may be present as acid in its free form, in its salt form and/or in its ester form. The composition may be used as an antibacterial agent against gram-negative bacteria in various products, applications and methods.Type: ApplicationFiled: May 24, 2011Publication date: September 22, 2011Applicant: PURAC BIOCHEM B.V.Inventors: Roel Otto, Aldana Mariel Ramirez, Diderik Reinder Kremer
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Patent number: 7973006Abstract: The present invention relates to an antibacterial composition based on a combination of fatty acid ester of fatty acid and hydroxy carboxylic acid with an antibacterial agent selected from polylysine, protamine, their salts and mixtures hereof. The hydroxy carboxylic acid may be present as acid in its free form, in its salt form and/or in its ester form. The present invention further is directed to the use of said composition as antibacterial agent against gram-negative bacteria in various products, applications and methods. Furthermore, the present invention is related to products comprising said antibacterial agent.Type: GrantFiled: September 17, 2008Date of Patent: July 5, 2011Assignee: Purac Biochem B.V.Inventors: Roel Otto, Aldana Mariel Ramirez, Diderik Reinder Kremer
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Patent number: 7618664Abstract: The invention provides for a method for the preparation of a gluconic acid from glucose. It is an aspect of the invention to provide a method that comprises the use of enzymes. The method according to the invention can be applied with great benefit to the production of calcium gluconate suitable for use as a food fortifier by a process that is economical.Type: GrantFiled: October 7, 2002Date of Patent: November 17, 2009Assignee: Cooperatieve Verkoop-en Productievereniging Van Aardappelmeel en Derivaten Avebe B.A.Inventors: Marcus Johannes Anthonius Wilhelmus Vorage, Diderik Reinder Kremer, Boelem Sloots, Johannes Bernardus Maria Meiberg
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Publication number: 20090104339Abstract: The invention provides for a method for the preparation of a gluconic acid from glucose. It is an aspect of the invention to provide a method that comprises the use of enzymes. The method according to the invention can be applied with great benefit to the production of calcium gluconate suitable for use as a food fortifier by a process that is economical.Type: ApplicationFiled: December 19, 2008Publication date: April 23, 2009Applicant: PURAC BIOCHEM B.V.Inventors: Marcus Johannes Anthonius Wilhelmus Vorage, Diderik Reinder KREMER, Boelem SLOOTS, Johannes Bernardus Maria MEIBERG
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Publication number: 20090082253Abstract: The present invention relates to an antibacterial composition based on a combination of fatty acid ester of fatty acid and hydroxy carboxylic acid with an antibacterial agent selected from polylysine, protamine, their salts and mixtures hereof. The hydroxy carboxylic acid may be present as acid in its free form, in its salt form and/or in its ester form. The present invention further is directed to the use of said composition as antibacterial agent against gram-negative bacteria in various products, applications and methods. Furthermore, the present invention is related to products comprising said antibacterial agent.Type: ApplicationFiled: September 17, 2008Publication date: March 26, 2009Applicant: PURAC BIOCHEM B.V.Inventors: Roel Otto, Aldana Mariel Ramirez, Diderik Reinder Kremer
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Publication number: 20090082443Abstract: The present invention relates to a method for the prevention and/or reduction of the presence, growth and/or activity of gram-negative bacteria comprising application of a composition comprising glycerol-based fatty acid esters and polylysine and/or salts of polylysine, wherein said glycerol-based fatty acid ester is used as antibacterial agent. The present invention further relates to the use of said composition as antibacterial agent in various products and applications ranging from technical products and personal-care products to food and drink products for animals and human consumption.Type: ApplicationFiled: September 17, 2008Publication date: March 26, 2009Applicant: PURAC BIOCHEM B.V.Inventors: Roel Otto, Aldana Mariel Ramirez, Diderik Reinder Kremer
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Publication number: 20080152764Abstract: The invention pertains to a particulate composition comprising calcium lactate and calcium citrate microparticles having an average diameter from 0.1 ?m to 20 ?m, wherein the composition is in the form of particles with an average diameter from 25 ?m to 1 mm, wherein the ratio by weight of calcium lactate to calcium citrate, based on the dry weight, is 80:20 to 30:70, and wherein the calcium lactate is a non-polymeric agglomeration agent for the calcium citrate microparticles. The invention further relates to a process for producing the particulate composition wherein an aqueous solution of calcium lactate comprising calcium citrate microparticles is spray-dried to the particulate composition, to the use of the particulate composition as calcium-enhancer, and to alimentary products.Type: ApplicationFiled: December 10, 2007Publication date: June 26, 2008Applicant: PURAC BIOCHEM BVInventors: Diderik Reinder Kremer, Jildert Eelke Visser, Marcus Johannes Anthonium Wilhelmus Vorage