Patents by Inventor Didier Benard

Didier Benard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoindole derivatives, compositions containing same, preparation thereof and pharmaceutical uses thereof in particular as inhibitors of chaperone protein Hsp90 activities
    Patent number: 8034939
    Abstract: This invention relates to isoindole derivates of Formula I to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising administering of such derivatives.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 11, 2011
    Assignee: Aventis Pharma S.A..
    Inventors: Patrick Mailliet, Luc Bertin, Didier Benard, Chantal Carrez, François Vallee, Eric Bacque
  • Pyridazinone kinase inhibitors
    Patent number: 7968546
    Abstract: Disclosed are compounds of Formula I wherein X is and R2, R1, A, B, D, E, R9 are as defined herein useful for treating cancers.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: June 28, 2011
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Swen Hoelder, Gunter Muller, Karl Schoenafinger, David William Will, Hans Matter, Martin Bossart, Cecile Combeau, Christine Delaisi, Ingrid Sassoon, Anke Steinmetz, Didier Benard
  • Cyclic urea compounds, preparation thereof and pharmaceutical use thereof as kinase inhibitors
    Patent number: 7825115
    Abstract: The disclosure relates to a cyclic urea compound of formula I: as defined herein, to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use as an inhibitor on a protein kinase. Thus, the compound of formula I is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: November 2, 2010
    Assignee: Aventis Pharma S.A.
    Inventors: Marcel Patek, Anil Nair, Augustin Hittinger, Conception Nemecek, Daniel Bond, Greg Harlow, Herve Bouchard, Jacques Mauger, Jean-Luc Malleron, Mark Palermo, Fahad Al-Obeidi, Thomas Faitg, Hartmut Strobel, Sven Ruf, Kurt Ritter, Youssef El-Ahmad, Dominique Lesuisse, Didier Bénard
  • Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
    Patent number: 7759379
    Abstract: The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4?, R4?, R4??, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: July 20, 2010
    Assignee: Aventis Pharma S.A.
    Inventors: Hartmut Strobel, Sven Ruf, Dominique Lesuisse, Conception Nemecek, Youssef El-Ahmad, Stefan Guessregen, Anne Lebrun, Kurt Ritter, Didier Benard, Augustin Hittinger, Hervé Bouchard
  • Fluorene derivatives, composition containing said derivatives and the use thereof
    Patent number: 7674795
    Abstract: This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising administering such derivatives.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: March 9, 2010
    Assignee: Aventis Pharma SA
    Inventors: Patrick Mailliet, Luc Bertin, Fabienne Thompson, Jean-Marie Ruxer, Fabienne Pilorge, Didier Benard, Hervé Minoux, Chantal Carrez, Hélène Goulaouic, Thierry Gouyon
  • Novel Pyridazinone Derivatives
    Publication number: 20090130209
    Abstract: Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
    Type: Application
    Filed: January 26, 2009
    Publication date: May 21, 2009
    Applicant: Aventis Pharma S.A.
    Inventors: Swen HOELDER, Gunter MULLER, Karl SCHOENAFINGER, David William WILL, Hans MATTER, Martin BOSSART, Cecile COMBEAU, Christine DELAISI, Ingrid SASSOON, Anke STEINMETZ, Didier BENARD
  • Pyridazinone derivatives
    Patent number: 7507734
    Abstract: Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: March 24, 2009
    Assignee: Aventis Pharma S.A.
    Inventors: Swen Hoelder, Gunter Muller, Karl Schoenafinger, David William Will, Hans Matter, Martin Bossart, Cecile Combeau, Christine Delaisi, Ingrid Sassoon, Anke Steinmetz, Didier Benard
  • Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof
    Publication number: 20080153837
    Abstract: This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising administering such derivatives.
    Type: Application
    Filed: November 14, 2007
    Publication date: June 26, 2008
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Patrick MAILLIET, Luc BERTIN, Fabienne THOMPSON, Jean-Marie RUXER, Fabienne PILORGE, Didier BENARD, Herve MINOUX, Chantal CARREZ, Helene GOULAOUIC, Thierry GUYON
  • Novel Isoindole Derivatives, Compositions Containing Same, Preparation Thereof and Pharmaceutical Uses Thereof in Particular as Inhibitors of Chaperone Protein HSP90 Activities
    Publication number: 20080119507
    Abstract: This invention relates to isoindole derivates of Formula I to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising administering of such derivatives.
    Type: Application
    Filed: September 28, 2007
    Publication date: May 22, 2008
    Applicant: Aventis Pharma S.A.
    Inventors: Patrick MAILLIET, Luc BERTIN, Didier BENARD, Chantal CARREZ, Francois VALLEE, Eric BACQUE
  • Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
    Patent number: 7354933
    Abstract: The present invention relates to a cyclic urea compound of formula I: as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use, as an inhibitor on a protein kinase. Thus, it is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: April 8, 2008
    Assignee: Aventis Pharma SA
    Inventors: Marcel Patek, Anil Nair, Augustin Hittinger, Conception Nemecek, Daniel Bond, Greg Harlow, Herve Bouchard, Jacques Mauger, Jean-Luc Malleron, Mark Palermo, Fahad Al-Obeidi, Thomas Faitg, Hartmut Strobel, Sven Ruf, Kurt Ritter, Youssef El-Ahmad, Dominique Lesuisse, Didier Bénard
  • Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors
    Publication number: 20080004300
    Abstract: The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4?, R4?, R4??, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
    Type: Application
    Filed: January 26, 2007
    Publication date: January 3, 2008
    Applicant: Aventis Pharma S.A.
    Inventors: Hartmut Strobel, Sven Ruf, Dominique Lesuisse, Conception Nemecek, Youssef El-Ahmad, Stefan Guessregen, Anne Lebrun, Kurt Ritter, Didier Benard, Augustin Hittinger, Herve Bouchard
  • Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation
    Patent number: 7223758
    Abstract: The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined herein, pharmaceutical composition thereof, process for its preparation, and its pharmaceutical use.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: May 29, 2007
    Assignee: Sanofi-Aventis
    Inventors: Neerja Bhatnagar, Didier Benard, Jean-Francois Gourvest, Jacques Mauger
  • Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation
    Publication number: 20050165017
    Abstract: The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined herein, pharmaceutical composition thereof, process for its preparation, and its pharmaceutical use.
    Type: Application
    Filed: August 11, 2004
    Publication date: July 28, 2005
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Neerja Bhatnagar, Didier Benard, Jean-Francois Gourvest, Jacques Mauger
  • Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use
    Publication number: 20050154048
    Abstract: The invention concerns novel compounds of formula (I), process for making, pharmaceutical compositions and methods of treating diseases associated with abnormal physiological behavior in the secretion and/or the activity of cysteine proteases especially cathepsins.
    Type: Application
    Filed: January 4, 2005
    Publication date: July 14, 2005
    Applicant: Aventis Pharma S.A.
    Inventors: Didier Benard, Jean-Francois Gourvest