Patents by Inventor Didier Mazel

Didier Mazel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC ATTC RECOMBINATION SITES FOR PROTEIN DOMAIN SHUFFLING
    Publication number: 20200165600
    Abstract: Recombinant nucleic acids comprising a protein coding sequence of a multidomain protein, wherein the protein coding sequence comprises at least one synthetic attC recombination site are provided. Cells comprising the recombinant nucleic acids and methods of making the recombinant nucleic acids are also provided, among other things.
    Type: Application
    Filed: July 28, 2017
    Publication date: May 28, 2020
    Inventors: Didier MAZEL, Aleksandra NIVINA, David BIKARD, Maj Svea GRIEB
  • Method for obtaining new life forms
    Patent number: 7960103
    Abstract: The present invention relates to a method for generating a novel form of life comprising the steps consisting of: a) irreversible alteration of the genome of a microbial clone; b) cultivation of a vast population of microbial cells originating from the altered clone obtained in step a) during numerous generations under conditions allowing selection for a higher and stable proliferation rate; c) isolation of descendant clones within the cultivated population of step b) still bearing the alteration of step a).
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: June 14, 2011
    Assignees: Institut Pasteur, Evologic SA, Centre National de la Recherche Scientifique
    Inventors: Rupert Mutzel, Philippe Marliere, Didier Mazel
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Patent number: 7399611
    Abstract: Eubacterial cells which produce non-formylated proteins, polypeptides and/or peptides and methods for making such non-formylated products. The eubacterial cells may be produced by inactivating or deleting the def (deformylase) and/or fmt (Met-tRNA transformylase) gene(s) from the def-fmt operon of the corresponding wild-type strain.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: July 15, 2008
    Assignee: Institut Pasteur
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel
  • Method for Modulating the Evolution of a Polypeptide Encoded by a Nucleic Acid Sequence
    Publication number: 20080044825
    Abstract: A method for modulating the ability of a gene to mutate by analyzing codon usage within the gene and selecting a synonymous nucleotide sequence with a higher, lower or different capacity to mutate. The method permits widening and optimization of the evolutionary landscape of a protein. A computer-implemented method for analyzing and selecting nucleotide sequences with an altered ability to mutate.
    Type: Application
    Filed: September 19, 2005
    Publication date: February 21, 2008
    Applicant: INSTITUT PASTEUR
    Inventors: Didier Mazel, Guillaume Cambray
  • Method for obtaining new life forms
    Publication number: 20070212781
    Abstract: The present invention relates to a method for generating a novel form of life comprising the steps consisting of: a) irreversible alteration of the genome of a microbial clone; b) cultivation of a vast population of microbial cells originating from the altered clone obtained in step a) during numerous generations under conditions allowing selection for a higher and stable proliferation rate; c) isolation of descendant clones within the cultivated population of step b) still bearing the alteration of step a).
    Type: Application
    Filed: September 13, 2006
    Publication date: September 13, 2007
    Applicants: INSTITUT PASTEUR, EVOLOGIC SA, Rupert MUTZEL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Rupert Mutzel, Philippe Marliere, Didier Mazel
  • Method for modulating the evolution of a polypeptide encoded by a nucleic acid sequence
    Publication number: 20060177839
    Abstract: A method for modulating the ability of a gene to mutate by analyzing codon usage within the gene and selecting a synonymous nucleotide sequence with a higher, lower or different capacity to mutate. The method permits widening and optimization of the evolutionary landscape of a protein. A computer-implemented method for analyzing and selecting nucleotide sequences with an altered ability to mutate.
    Type: Application
    Filed: September 19, 2005
    Publication date: August 10, 2006
    Inventors: Didier Mazel, Guillaume Cambray
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Publication number: 20060014250
    Abstract: Eubacterial cells which produce non-formylated proteins, polypeptides and/or peptides and methods for making such non-formylated products. The eubacterial cells may be produced by inactivating or deleting the def (deformylase) and/or fmt (Met-tRNA transformylase) gene(s) from the def-fmt operon of the corresponding wild-type strain.
    Type: Application
    Filed: July 8, 2005
    Publication date: January 19, 2006
    Applicant: INSTITUT PASTEUR
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Patent number: 6962807
    Abstract: The present invention relates to producing non-formylated proteins and/or peptides in bacterial cells lacking deformylase and/or transformylase.
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: November 8, 2005
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Publication number: 20030143680
    Abstract: The present invention relates to producing non-formylated proteins and/or peptides in bacterial cells lacking deformylase and/or transformylase.
    Type: Application
    Filed: July 8, 2002
    Publication date: July 31, 2003
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel