Patents by Inventor Didier Schils

Didier Schils has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Patent number: 11072582
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: July 27, 2021
    Assignee: Epics Therapeutics
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • SUBSTITUTED PYRROLIDINES AS G-PROTEIN COUPLED RECEPTOR 43 AGONISTS
    Publication number: 20200347016
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Application
    Filed: July 15, 2020
    Publication date: November 5, 2020
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Patent number: 10781171
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: September 22, 2020
    Assignee: Epics Therapeutics
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS AS AGONISTS OF G-PROTEIN COUPLED RECEPTOR 43 (GPR43)
    Publication number: 20200148636
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 14, 2020
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Patent number: 10577318
    Abstract: The present invention is directed to novel intermediates of the formula E: which are useful in the synthesis of agonists of g-protein coupled receptor 43 for treating and/or preventing metabolic diseases.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 3, 2020
    Assignee: Epics Therapeutics
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • SUBSTITUTED PYRROLIDINES AS G-PROTEIN COUPLED RECEPTOR 43 AGONISTS
    Publication number: 20190300478
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and or preventing metabolic diseases.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 3, 2019
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Patent number: 10358416
    Abstract: The present invention is directed to a process for the preparation of aryl-carbonyl-pyrrolidine carboxylic acid derivative compounds which are useful in treating metabolic diseases, said process consisting of coupling a pyrrolidine ester compound with an aryl carboxylic acid derivative, followed by alkaline or acidic treatment, hydrogenolysis or treatment with a fluoride of the obtained intermediate, to afford novel aryl-carbonyl-pyrrolidine carboxylic acid derivative compounds.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: July 23, 2019
    Assignee: Epics Therapeutics
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • SUBSTITUTED PYRROLIDINES AS G-PROTEIN COUPLED RECEPTOR 43 AGONISTS
    Publication number: 20180297944
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Application
    Filed: June 20, 2018
    Publication date: October 18, 2018
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Patent number: 10017468
    Abstract: The present invention is directed to a process for the preparation of aryl-pyrrolidine carboxylic acid derivative compounds which are useful in treating metabolic diseases, said process consisting of coupling an aryl-pyrrolidine compound with an aryl carboxylic acid compound followed by alkaline or acidic treatment, hydrogenolysis or treatment with a fluoride of the ester intermediate to afford novel aryl-pyrrolidine carboxylic acid derivative compounds.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: July 10, 2018
    Assignee: Ogeda SA
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • SUBSTITUTED PYRROLIDINES AS G-PROTEIN COUPLED RECEPTOR 43 AGONISTS
    Publication number: 20170283376
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Application
    Filed: June 15, 2017
    Publication date: October 5, 2017
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases
    Patent number: 9770435
    Abstract: Compounds of formula I are useful in treating and/or preventing inflammatory diseases.
    Type: Grant
    Filed: November 27, 2014
    Date of Patent: September 26, 2017
    Assignee: OGEDA SA
    Inventors: Hamid Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq, Jerome Bernard, Graeme Fraser
  • Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Patent number: 9695120
    Abstract: The present invention is directed to novel pyrrolidine carboxylic acid derivatives, pharmaceutical compositions, and their use in treating and/or preventing metabolic diseases as agonists of g-protein coupled receptor 43.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: July 4, 2017
    Assignee: Ogeda SA
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING INFLAMMATORY DISEASES
    Publication number: 20160303075
    Abstract: Compounds of formula I are useful in treating and/or preventing inflammatory diseases.
    Type: Application
    Filed: November 27, 2014
    Publication date: October 20, 2016
    Inventors: Hamid HOVEYDA, Didier SCHILS, Ludivine ZOUTE, Julien PARCQ, Jerome BERNARD, Graeme FRASER
  • PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS AS AGONISTS OF G-PROTEIN COUPLED RECEPTOR 43 (GPR43)
    Publication number: 20130023539
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Application
    Filed: June 18, 2012
    Publication date: January 24, 2013
    Applicant: Euroscreen S.A.
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
    Publication number: 20110230477
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.
    Type: Application
    Filed: December 7, 2009
    Publication date: September 22, 2011
    Applicant: Euroscreen S.A.
    Inventors: Hamid Hoveyda, Cyrille Evangelos Brantis, Guillaume Dutheuil, Ludivine Zoute, Didier Schils, Jerome Bernard
  • PROCESSES FOR THE PREPARATION OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]-2-PYRIMIDINYL]AMINO]BENZONITRILE
    Publication number: 20070191407
    Abstract: Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).
    Type: Application
    Filed: April 23, 2007
    Publication date: August 16, 2007
    Inventors: Didier Schils, Joannes Willems, Bart Petrus Anna Medaer, Elisabeth Therese Pasquier, Paul Janssen, Jan Heeres, Ruben Gerardus Leenders, Jerome Guillemont