Patents by Inventor Didier Trono

Didier Trono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA export element and methods of use
    Patent number: 6287814
    Abstract: A cis-acting posttranscriptional regulatory element (PRE) useful for efficient RNA export of RNA is provided. The element, termed WPRE, is originally derived from woodchuck hepatitis virus. The invention also provides a method for enhancing the expression of transgenes by insertion of the WPRE nucleic acid sequences in operably linkage with the transgene.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: September 11, 2001
    Assignee: Salk Institute
    Inventors: Thomas J. Hope, Romain Zufferey, Didier Trono, John Edward Donello
  • RNA export element and methods of use
    Patent number: 6284469
    Abstract: A cis-acting posttranscriptional regulatory element (PRE) useful for efficient RNA export of RNA is provided. The element, termed WPRE, is originally derived from woodchuck hepatitis virus. The invention also provides a method for enhancing the expression of transgenes by insertion of the WPRE nucleic acid sequences in operably linkage with the transgene.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: September 4, 2001
    Assignee: The Salk Institute
    Inventors: Thomas J. Hope, Romain Zufferey, Didier Trono, John Edward Donello
  • RNA export element
    Patent number: 6136597
    Abstract: A cis-acting posttranscriptional regulatory element (PRE) useful for efficient RNA export of RNA is provided. The element termed WPRE, is originally derived from woodchuck hepatitis virus. The invention also provides a method for enhancing the expression of transgenes by insertion of the WPRE nucleic acid sequences in operably linkage with the transgene.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: October 24, 2000
    Assignee: The Salk Institute for Biological Studies
    Inventors: Thomas J. Hope, Romain Zufferey, Didier Trono, John Edward Donello
  • Vector and method of use for nucleic acid delivery to non-dividing cells
    Patent number: 6013516
    Abstract: A recombinant retrovirus capable of infecting a non-dividing cell and a method of producing such a virus is provided. The recombinant retrovirus is preferably of lentivirus origin and is useful for the treatment of a variety of disorders including neurological disorders and disorders of other non-dividing cells.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: January 11, 2000
    Assignee: The Salk Institute for Biological Studies
    Inventors: Inder Verma, Didier Trono, Luigi Naldini, Philippe Gallay
  • Non-infectious HIV particles and uses therefor
    Patent number: 5919458
    Abstract: This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 6, 1999
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Anna Aldovini, Richard A. Young, Mark B. Feinberg, Didier Trono, David Baltimore
  • Non-infectious HIV particles and uses therefor
    Patent number: 5861282
    Abstract: This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: January 19, 1999
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Anna Aldovini, Richard A. Young, Mark B. Feinberg, Didier Trono, David Baltimore
  • Gene expression in mammalian cells using a cap independent 5' noncoding region
    Patent number: 5358856
    Abstract: A construct which includes a cap independent 5' noncoding region of viral or cellular origin and a nucleotide sequence of interest, which is located downstream of the noncoding region. A method of producing a protein or a polypeptide of interest by introducing the construct, including a nucleotide sequence encoding the protein or the polypeptide of interest, into mammalian cells is also described. In one embodiment, the construct comprises all or a portion of the poliovirus cap independent 5' noncoding region and a nucleotide sequence encoding a protein or a polypeptide of interest.
    Type: Grant
    Filed: May 18, 1992
    Date of Patent: October 25, 1994
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: David Baltimore, Didier Trono