Abstract: An apparatus for photonic biosensors for multiplexed diagnostics and a method of use are disclosed. The apparatus includes a portable device configured for point-of-care diagnostics. The portable device includes a photonic sensor chip that includes one or more resonators that is substantially in contact with at least a fluid that includes one or more analytes and the reader device communicatively connected to the photonic sensor chip that includes at least a light source and the reader device is configured to provide an input optical signal using the at least a light source, receive the one or more sensor signals from the photonic sensor chip and determine one or more characteristics of the one or more analytes as a function of the one or more sensor signals and a connecting system, wherein the connecting system is configured to connect the photonic sensor chip and the reader device.

Abstract: An apparatus for performing analyte detection, wherein the apparatus comprises an optoelectronic reader device, the optoelectronic reader device comprising a microfluidic subassembly comprising a microfluidic pump, the microfluidic pump configured to route the flow of at least a fluid, wherein the at least a fluid contains an analyte, and at least a reservoir configured to contain the at least a fluid, an optics subassembly, the optics subassembly comprising an optical device having at least one light source directed at the at least a fluid, and a sensor device configured to sense the at least a fluid and detect at least an optical property of the analyte, and a portable device, wherein the portable device is configured for point of care diagnostics.

Abstract: An apparatus for controlling assay steps using active flow components, the apparatus includes a microfluidic device containing a reservoir configured to contain a fluid and microfluidic channels connected to the reservoir, wherein the microfluidic channels are configured to create a microfluidic environment for an assay, active flow components, a sensor device configured to detect a sensed property of the fluid, and an external device connected to the microfluidic device including actuators, wherein the actuators are configured to connect the active flow components using a mechanical interface and initiate active flow processes corresponds to assay steps of the assay based on the active flow components, and a reading device configured to read the sensed property of the fluid from the sensor device, wherein the active flow components are configured to flow the fluid bi-directionally through the sensor device within the microfluidic environment based on active flow processes.

Abstract: Apparatus of a multipurpose fluid extraction device for diagnostics and method of use are disclosed. The apparatus includes a fluid extraction system, wherein the fluid extraction system is configured to extract a fluid from a user, a microfluidic assembly, wherein the microfluidic assembly is configured to provide a flow of extracted fluid, where the microfluidic assembly includes a microfluidic channel, a photonic sensor, wherein the photonic sensor is configured to output a sensor signal to a reader device that is configured to detect one or more characteristics of the extracted fluid as a function of the sensor signal, an assay component fluidically connected to the microfluidic assembly, wherein the assay component is configured for testing the extracted fluid and a fluid collecting reservoir fluidically connected to the microfluidic assembly, wherein the fluid collecting reservoir is configured to collect the extracted fluid from the microfluidic assembly.

Abstract: Systems and methods for coupling photonic integrated subcircuits are described herein. The example system can include a first cartridge (4702) including a first photonic integrated subcircuit (4706) and a first alignment feature (4720, 4722). The system can include a second cartridge (4704) including a second photonic integrated subcircuit (4708) and a second alignment feature (4724, 4726), where the first alignment feature (4720, 4722) and the second alignment feature (4724, 4726) can be configured to enable alignment between the first photonic integrated subcircuit (4706) and the second photonic integrated subcircuit (4708). When the first photonic integrated subcircuit (4706) is aligned to the second photonic integrated subcircuit (4708), a first light path of the first photonic integrated subcircuit (4706) can be optically coupled to a second light path of the second photonic integrated subcircuit (4708).

Abstract: Systems and methods for generating a virtual environment for implementing an integrated photonics assembly are presented. An example system can include one or more processors and a memory coupled with the processors, where the processor executes a plurality of modules stored in the memory. The plurality of modules can include a user interface module for deploying one or more virtual photonic integrated subcircuits within the virtual environment, in which the virtual environment is configured to enable coupling of at least two virtual photonic integrated subcircuits. The coupling of the virtual photonic integrated subcircuits can form a virtual integrated photonics assembly. The modules can include a library module comprising a plurality of virtual photonic integrated subcircuits. One or more virtual photonic integrated subcircuits can include a performance characteristic.

Abstract: Disclosed herein are integrated photonics systems (3800) for biosensing including an interrogator photonic circuit (3802) and cartridge (3804) and methods using these systems. The cartridge (3804) comprises a sensor photonic integrated subcircuit. The cartridge (3804) is configured to receive a biological sample. The interrogator photonic circuit (3802) is optically coupled to the cartridge (3804) an comprises: (i) a light source (3806) configured to generate light; and (ii) one or more waveguides configured to carry the light, wherein the light is used to determine a characteristic of the biological sample in the cartridge (3804). A system can have an assembly of a plurality of modular photonic integrated subcircuits. Each subcircuit can be pre-fabricated and can be configured to transfer light to and receive light from another subcircuit based on the first functionality.

Abstract: Disclosed herein are integrated photonics assemblies, circuits, systems and methods therefor. The systems can include a first integrated photonics assembly having a first functionality, in which the first assembly includes a plurality of modular photonic integrated subcircuits. Each subcircuit can be pre-fabricated and can be configured to transfer light to and receive light from another subcircuit based on the first functionality. An output port of a first subset of the subcircuits can be configured to be aligned with an input port of a second subset of the subcircuits. At least one subcircuit can be configured to be removed from the first integrated photonics assembly and connected to a second integrated photonics assembly having a second functionality. The first integrated photonics assembly can be different from the second integrated photonics assembly and the first functionality can be different from the second functionality.

Abstract: Aspects relate to systems and methods for fluid sensing using passive flow. An exemplary system includes a microfluidic device, the microfluidic device including at least a reservoir configured to contain at least a fluid and at least a passive flow component in fluidic communication with the at least a reservoir and configured to flow the at least a fluid with predetermined flow properties, at least an sensor device configured to be in sensed communication with the at least a fluid and detect at least a sensed property; and at least an sensor interface configured to wet at least a surface of the at least a sensor device with the at least a fluid.

Abstract: A method of tagged-base DNA sequencing readout on waveguide surfaces includes immobilizing, a surface of a waveguide, a nucleotide fragment, exposing the nucleotide fragment to a first plurality of capped nucleotides, wherein the first plurality of capped nucleotides include a first plurality of nucleotide types, each distinct nucleotide type has a distinct capping agent, and each distinct capping agent has a distinct optical signature, severing base pair connections between the at least a nucleotide fragment and the first plurality of capped nucleotides, wherein the nucleotide fragment remains attached and a first single nucleotide, of the first plurality of capped nucleotides, remains immobilized on a nucleotide binding locus adjacent to the first nucleotide sequence, and detecting a first distinct optical signature of a first distinct capping agent of the first single nucleotide using the waveguide.

Abstract: Aspects relate to methods and systems for optical matrix calculation. An exemplary system includes at least a first light source configured to output at least a first optical output having a first wavelength, at least a second light source configured to output at least a second optical output having a second wavelength substantially different from the first wavelength, at least an optical modulator configured to modulate the at least a first optical output, at least an optical matrix multiplier configured to perform at least two matrix multiplications, a first matrix multiplication as a function of the first optical output and a second matrix multiplication as a function of the second optical output, and at least a photodetector configured to measure the at least a first optical output and the at least a second optical output.