Patents by Inventor Diego Jaitin

Diego Jaitin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240239886
    Abstract: Provided are antibodies to TREM2 and Gpnmb. Also provided are compositions comprising the antibodies and methods of using same.
    Type: Application
    Filed: February 5, 2024
    Publication date: July 18, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Chamutal BORNSTEIN-OVITS, Adam YALIN, Adi MOSHE, Oren BARBOY, Assaf WEINER, Yonatan KATZENELENBOGEN, Diego JAITIN, Fadi SHEBAN
  • Patent number: 11485971
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 1, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ido Amit, Diego Jaitin, David Lara-Astiaso, Assaf Weiner, Ido Yofe
  • Publication number: 20220307008
    Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 29, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Ido YOFE, Diego JAITIN, Yonatan KATZENELENBOGEN, Mami LENNIKOV, Assaf WEINER, Hadas KEREN-SHAUL
  • Publication number: 20200263168
    Abstract: Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded DNA portion of 15 base pairs and no more than 100 base pairs with a 3?single stranded overhang of at least 3 bases and no more than 10 bases, wherein the double stranded DNA portion is at the 5? end of the polynucleotide and wherein the sequence of the 3?single stranded overhang is selected from the group consisting of SEQ ID NOs: 1-8 and 9, wherein the 5? end of the strand of the double-stranded DNA which is devoid of the 3?single stranded overhang comprises a free phosphate.
    Type: Application
    Filed: February 7, 2020
    Publication date: August 20, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Diego JAITIN, Ido AMIT, Hadas KEREN-SHAUL, Liran VALADARSKY
  • Publication number: 20190194653
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Application
    Filed: September 14, 2017
    Publication date: June 27, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Diego JAITIN, David LARA-ASTIASO, Assaf WEINER, Ido YOFE
  • Publication number: 20170137806
    Abstract: Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded DNA portion of 15 base pairs and no more than 100 base pairs with a 3?single stranded overhang of at least 3 bases and no more than 10 bases, wherein said double stranded DNA portion is at the 5? end of the polynucleotide and wherein the sequence of said 3? single stranded overhang is selected from the group consisting of SEQ ID NOs: 1-8 and 9, wherein the 5? end of the strand of said double-stranded DNA which is devoid of said 3? single stranded overhang comprises a free phosphate.
    Type: Application
    Filed: January 23, 2017
    Publication date: May 18, 2017
    Inventors: Diego JAITIN, Ido Amit, Hadas Keren-Shaul, Liran Valadarsky
  • Publication number: 20150307874
    Abstract: Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded DNA portion of 15 base pairs and no more than 100 base pairs with a 3? single stranded overhang of at least 3 bases and no more than 10 bases, wherein said double stranded DNA portion is at the 5? end of the polynucleotide and wherein the sequence of said 3? single stranded overhang is selected from the group consisting of SEQ ID NOs: 1-8 and 9, wherein the 5? end of the strand of said double-stranded DNA which is devoid of said 3? single stranded overhang comprises a free phosphate.
    Type: Application
    Filed: July 9, 2015
    Publication date: October 29, 2015
    Inventors: Diego JAITIN, Ido Amit, Hadas Keren-Shaul, Liran Valadarsky
  • Patent number: 7919078
    Abstract: The present invention provides IFN?2 mutants and active fragments, analogs, derivatives, and variants thereof, nucleotide molecules encoding same, pharmaceutical compositions containing the same, and methods utilizing the same for treating cancer, infectious diseases, and autoimmune diseases.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: April 5, 2011
    Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Gideon E Schreiber, Laila C. Roisman, Diego Jaitin, Eyal Kalie
  • Patent number: 7767799
    Abstract: The present invention provides IFN?2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFN?2. The present invention further provides pharmaceutical compositions comprising IFN?2 mutants useful for treating or preventing cancer, autoimmune diseases, infectious diseases or disorders associated with increased expression of IFN?2.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: August 3, 2010
    Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Gideon E Schreiber, Laila C. Roisman, Diego Jaitin, Eyal Kalie
  • Publication number: 20080279823
    Abstract: The present invention provides IFN?2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFN?2. The present invention further provides pharmaceutical compositions comprising IFN?2 mutants useful for treating or preventing cancer, autoimmune diseases, infectious diseases or disorders associated with increased expression of IFN?2.
    Type: Application
    Filed: June 28, 2006
    Publication date: November 13, 2008
    Inventors: Gideon E. Schreiber, Laila C. Roisman, Diego Jaitin, Eyal Kalie
  • Publication number: 20080166319
    Abstract: The present invention provides IFN?2 mutants and active fragments, analogs, derivatives, and variants thereof, nucleotide molecules encoding same, pharmaceutical compositions containing the same, and methods utilizing the same for treating cancer, infectious diseases, and autoimmune diseases.
    Type: Application
    Filed: January 4, 2008
    Publication date: July 10, 2008
    Inventors: Gideon E Schreiber, Laila C. Roisman, Diego Jaitin, Eyal Kalie