Patents by Inventor Diego Ploper

Diego Ploper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemically coupled transporter for low-hydrophobicity bioactive drugs into the central nervous system
    Patent number: 12636371
    Abstract: The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, wherein the modified tetracycline derivative is optionally defined by the following formula:
    Type: Grant
    Filed: February 28, 2024
    Date of Patent: May 26, 2026
    Assignees: Skybio LLC, Consejo Nacional de Investigaciones Cientificas y Tecnias (Conicet), Universidad Nacional de Tucumán, Universidad de Buneos Aries, Sistema Provincial De Salud De Tucumán
    Inventors: Oscar José Varela, Rosana Nieves Chehín, Cesar Luis Ávila, Sergio Benjamin Socías, Diego Ploper, Esteban Vera Pingitore, Analía Silvina Chaves, Martin Luong, Verónica Elena Manzano, Rodrigo Hernán Tomas Grau, Maria Florencia González Lizárraga, Adriana Andrea Kolender, Agustín Osvaldo Pernicone
  • DEVICE AND METHOD FOR THE DETECTION OF BIOMARKERS ASSOCIATED WITH NEURODEGENERATIVE DISEASES
    Publication number: 20250305982
    Abstract: The present disclosure provides devices for the detection and/or quantification of neurotoxic amyloid-type protein aggregates, comprising a doxycycline derivative immobilized on an appropriate surface, as well as electrochemical and immunochemical methods associated to the use of such devices.
    Type: Application
    Filed: May 5, 2023
    Publication date: October 2, 2025
    Applicants: CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), UNIVERSIDAD NACIONAL DE TUCUMÁN, SISTEMA PROVINCIAL DE SALUD DE TUCUMÁN, SKYBIO LLC, UNIVERSIDAD DE BUENOS AIRES
    Inventors: Oscar José VARELA, Rosana Nieves CHEHÍN, Cesar Luis ÁVILA, Sergio Benjamín SOCÍAS, Diego PLOPER, Esteban VERA PINGITORE, Martín LUONG, Verónica Elena MANZANO, Rossana Elena MADRID, Adriana Andrea KOLENDER, María Belén MACHÍN, Agustín Osvaldo PERNICONE, Silvana Estefanía SOLIZ SANTANDER
  • Chemically Coupled Transporter for Low-Hydrophobicity Bioactive Drugs into the Central Nervous System
    Publication number: 20240197892
    Abstract: The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker defined by the generic formula XZX to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, particularly a compound wherein the modified tetracycline derivative is a chemically modified doxycycline derivative and the low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases is dopamine. The disclosure also provides a process for preparing such compound, as well as methods for treating a neurodegenerative disease comprising administering said compound.
    Type: Application
    Filed: February 28, 2024
    Publication date: June 20, 2024
    Inventors: Oscar José Varela, Rosana Nieves Chehín, Cesar Luis Ávila, Sergio Benjamin Socías, Diego Ploper, Esteban Vera Pingitore, Analía Silvina Chaves, Martin Luong, Verónica Elena Manzano, Rodrigo Hernán Tomas Grau, Maria Florencia González Lizárraga, Adriana Andrea Kolender, Agustín Osvaldo Pernicone
  • Chemically coupled transporter for low-hydrophobicity bioactive drugs into the central nervous system
    Patent number: 11951170
    Abstract: The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, wherein the modified tetracycline derivative is optionally defined by the following formula:
    Type: Grant
    Filed: March 14, 2023
    Date of Patent: April 9, 2024
    Assignees: Skybio LLC, Consejo Nacional de Investigaciones Cientificas y Ténicas (Conicet), Universidad Nacional de Tucumán, Universidad de Buenos Aires, Sistema Provincial De Salud De Tucumán
    Inventors: Oscar José Varela, Rosana Nieves Chehín, Cesar Luis Ávila, Sergio Benjamin Socías, Diego Ploper, Esteban Vera Pingitore, Analía Silvina Chaves, Martin Luong, Verónica Elena Manzano, Rodrigo Hernán Tomas Grau, Maria Florencia González Lizárraga, Adriana Andrea Kolender, Agustín Osvaldo Pernicone
  • Chemically Coupled Transporter for Low-Hydrophobicity Bioactive Drugs into the Central Nervous System
    Publication number: 20230218768
    Abstract: The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker defined by the generic formula XZX to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, particularly a compound wherein the modified tetracycline derivative is a chemically modified doxycycline derivative and the low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases is dopamine. The disclosure also provides a process for preparing such compound, as well as methods for treating a neurodegenerative disease comprising administering said compound.
    Type: Application
    Filed: March 14, 2023
    Publication date: July 13, 2023
    Inventors: Oscar José Varela, Rosana Nieves Chehín, Cesar Luis Ávila, Sergio Benjamin Socías, Diego Ploper, Esteban Vera Pingitore, Analía Silvina Chaves, Martin Luong, Verónica Elena Manzano, Rodrigo Hernán Tomas Grau, Maria Florencia González Lizárraga, Adriana Andrea Kolender, Agustín Osvaldo Pernicone