Abstract: The present invention provides therapeutics for the treatment of CD22-positive cancers such as B-cell acute lymphoblastic leukemia (B-ALL). In particular, the present invention provides an anti-CD22 monoclonal antibody whose scFv as a part of chimeric antigen receptors (CAR) T-cells can target the first Ig extracellular domain of the CD22 antigen, the farthest domain from the membrane, for use in the treatment of CD22-positive cancers.

Abstract: Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor T-cells (CARTs) to T-ALL remains challenging because the shared expression of target antigens between CARTs and T-ALL blasts leads to CARTs fratricide. CD1a is exclusively expressed in cortical T-ALLs, a major subset of T-ALL. The expression of CD1a is restricted to cortical thymocytes and neither CD34+ progenitors nor T-cells express CD1a during ontogeny, confining the risk of on-target/off-tumor toxicity. The present invention provides CARs comprising a CD 1a-targeting moiety which may be transduced or transformed into T cells. The resultant CARTs are suitable for the treatment of cortical T-ALLs.

Abstract: An auxetic bi-stable structure that comprises an auxetic curved shell movable between a first and a second stable position, and a rigid element. At least part of the surface of the auxetic curved shell is joined to the rigid element such that the curved shell is movable with respect to the rigid element between the first and second stable positions.

Abstract: A composite structure (1) for an aircraft, having at least one insert (2) for receiving attachment devices, each insert (2) includes a core (3) having a major dimension and containing at least one through-hole (4), and a composite strip arrangement formed by a first section (5) surrounding the core (3) and attached to said core (3) by an adhesive polymeric layer, and a second section (6) including at least one free end (6a). The first (5) and the second portion (6) of the composite strip arrangement are disposed over a first surface (1a) of the composite structure (1), such that the major dimension of the core (3) is positioned transversal to said first surface (1 a). The at least one insert (2) is co-cured with the composite structure (1).

Abstract: A method of determining occupancy of a vehicle along a route is determined by processing data generated by two different smartphones reported to be travelling in the same vehicle. An app executing within each smartphone. Information that has been transmitted from the two smartphones includes a unique identification of the mobile computing device and a unique identification of a person associated with the mobile computing device. Sensor data is also received, which corresponds to a local ambient environment inside the vehicle of the mobile computing device generating the data. The sensor data does not include location data or data entered by a user. The received data is used to determine if both mobile computing devices were actually present during the portions of the route, by comparing the data from each device.

Abstract: An auxetic bi-stable structure that comprises an auxetic curved shell movable between a first and a second stable position, and a rigid element. At least part of the surface of the auxetic curved shell is joined to the rigid element such that the curved shell is movable with respect to the rigid element between the first and second stable positions.

Abstract: A composite structure (1) for an aircraft, having at least one insert (2) for receiving attachment devices, each insert (2) includes a core (3) having a major dimension and containing at least one through-hole (4), and a composite strip arrangement formed by a first section (5) surrounding the core (3) and attached to said core (3) by an adhesive polymeric layer, and a second section (6) including at least one free end (6a). The first (5) and the second portion (6) of the composite strip arrangement are disposed over a first surface (1a) of the composite structure (1), such that the major dimension of the core (3) is positioned transversal to said first surface (1 a). The at least one insert (2) is co-cured with the composite structure (1).

Abstract: Various mechanisms presented in this disclosure provide for dynamically adjusting the exhibition of subtitles. In one example, check-points are introduced into the subtitle file format that, once achieved by a multimedia player, provoke the rescheduling of the moment in which the texts contained in the subtitle file will be exhibited.

Abstract: A method of determining occupancy of a vehicle along a route is determined by processing data generated by two different smartphones reported to be travelling in the same vehicle. An app executing within each smartphone. Information that has been transmitted from the two smartphones includes a unique identification of the mobile computing device and a unique identification of a person associated with the mobile computing device. Sensor data is also received, which corresponds to a local ambient environment inside the vehicle of the mobile computing device generating the data. The sensor data does not include location data or data entered by a user. The received data is used to determine if both mobile computing devices were actually present during the portions of the route, by comparing the data from each device.

Abstract: Determining occupancy of a vehicle during a trip can be carried out using a computer server which receives data from mobile computing devices within the vehicle. Each of the mobile computing devices is associated with a person, and sends to the server a unique identification of the vehicle, such as a license plate number, and also data generated during the trip from sensors within the device. The sensors collect data that relates to the local ambient environment of the device during the trip, such as a local magnetic field, movements, altitude, location, and sounds. The server compares the data from all devices in the vehicle to determine if the data from all of devices match, within predetermined limits. If there is a match, the server can provide a probable vehicle occupancy count; otherwise, the server can provide an indication that the vehicle occupancy should be investigated in another manner.

Abstract: To identify spaces on shelves which are not full of product and need restocking, markers having a pattern are placed on or near shelves containing product. A camera obtains an image of the shelf, products, and markers. A processor executing software is used to analyze the image to identify the markers and the shelf. Next, storage areas on the shelf are analyzed to identify vacant areas represented by a lower light intensity relative to adjacent areas. The processor determines a location of the vacant areas, and determines the size of the vacant areas using the known marker size and the size of the marker in the image, to generate a scale which is applied to the vacant area. This information and stored product information is used to determine which products should be restocked. The marker pattern can be selected to be readily recognizable by an image processing algorithm.

Abstract: Various mechanisms presented in this disclosure provide for dynamically adjusting the exhibition of subtitles. In one example, check-points are introduced into the subtitle file format that, once achieved by a multimedia player, provoke the rescheduling of the moment in which the texts contained in the subtitle file will be exhibited.

Abstract: Waiting time for the use of activities at a venue with multiple activities, such as an amusement park, is reduced by first receiving selections from visitors to the park using mobile phones, of desired activities and starting times. The selections are transmitted to a server which determines, for each user, waiting times associated with the desired starting times. The server then recommends alternative starting times for those activities. The alternative starting times are chosen to not only reduce the user's waiting time, but the waiting time for all users in the park. The alternative starting times are transmitted back to the mobile phones, where users can accept or reject the alternative starting times. The users are then placed into a virtual queue for each activity.

Abstract: Determining occupancy of a vehicle during a trip can be carried out using a computer server which receives data from mobile computing devices within the vehicle. Each of the mobile computing devices is associated with a person, and sends to the server a unique identification of the vehicle, such as a license plate number, and also data generated during the trip from sensors within the device. The sensors collect data that relates to the local ambient environment of the device during the trip, such as a local magnetic field, movements, altitude, location, and sounds. The server compares the data from all devices in the vehicle to determine if the data from all of devices match, within predetermined limits. If there is a match, the server can provide a probable vehicle occupancy count; otherwise, the server can provide an indication that the vehicle occupancy should be investigated in another manner.

Abstract: Various mechanisms presented in this disclosure provide for dynamically adjusting the exhibition of subtitles. In one example, check-points are introduced into the subtitle file format that, once achieved by a multimedia player, provoke the rescheduling of the moment in which the texts contained in the subtitle file will be exhibited.

Abstract: A method for calculating sales trend of a product at a store shelf based on crowdsourcing, includes receiving, by a retail store server, availability data of a product measured on a shelf in the retail store from a portable device, where the availability data is in the form of a picture acquired of the product on the shelf, identifying products on the shelf using tags attached to the shelves, calculating sales velocity and sales trends of the product from the identified products, and transmitting the sales velocity and sales trend of the product to one or more third parties' systems in a supply chain of said retail store. Products and their locations on retail store shelves have been cataloged in a product database.

Abstract: A system for executing a given scientific code using a suitable finite-volume or finite-element solver for a large dataset represented as a grid, comprising a plurality of equal computing nodes interconnected by node communication means and a parallel computing software package for distributing and controlling the execution in sub-grids among said computing nodes; each computing node comprising at least a CPU-based first processing means and a FPGA-based second processing means interconnected by a bus; said package being configured for the simultaneous execution of at least one first solver process (which is fully executed in a first processing means) and one second solver process (which is fully executed in a second processing means) in each computing node for one sub-grid of said grid and for managing the exchange of boundary data with the solver processes that solve neighbor sub-grids.

Abstract: A method for calculating sales trend of a product at a store shelf based on crowdsourcing, includes receiving, by a retail store server, availability data of a product measured on a shelf in the retail store from a portable device, where the availability data is in the form of a picture acquired of the product on the shelf, identifying products on the shelf using tags attached to the shelves, calculating sales velocity and sales trends of the product from the identified products, and transmitting the sales velocity and sales trend of the product to one or more third parties' systems in a supply chain of said retail store. Products and their locations on retail store shelves have been cataloged in a product database.

Abstract: A method of controlling access to content comprises receiving, at a domain gateway (3) of a domain (4), a request from a device (5) in the domain for access to the content. It is determined at the domain gateway whether the number of devices in the domain currently accessing the content is equal to a specified maximum number of devices that may simultaneously access the content. The maximum number of devices that may simultaneously access the content is independent of the number of devices in the domain. If the determination is that the number of devices in the domain currently accessing the content is less than the specified maximum number the request is allowed, otherwise it is refused.

Abstract: At least some of the illustrative embodiments are a non-transitory machine-readable storage medium including executable instructions that, when executed, cause one or more processors to receive drilling rig safety barrier data based on conditions of safety barriers in one or more drilling rigs. The one or more processors are further caused to identify, based on the drilling rig of safety barrier data, an impending invalidation of at least one of the safety barriers. The one or more processors are further caused to identify, based on the impending invalidation, one or more profiles for alert, and output, based on the one or more profiles, an alert of impending safety barrier invalidation.