Patents by Inventor Diego Sebastián D'Astolfo

Diego Sebastián D'Astolfo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSDUCTION BUFFER
    Publication number: 20210087585
    Abstract: The invention relates to transduction compounds, buffers and methods for introducing molecules into cells. The invention also relates to methods of treatment, pharmaceutical compositions and other uses of the transduction compounds and buffers. The invention also relates to modified cells obtainable by the transduction compounds, buffers and methods of the invention.
    Type: Application
    Filed: August 10, 2020
    Publication date: March 25, 2021
    Inventors: Niels Geijsen, Diego Sebastián D'Astolfo
  • DNA-PK INHIBITORS
    Publication number: 20210060028
    Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions, or disorders.
    Type: Application
    Filed: January 16, 2019
    Publication date: March 4, 2021
    Inventors: Marc Saul WEINBERG, Diego Sebastian D'ASTOLFO, Sudipta MAHAJAN
  • Transduction buffer
    Patent number: 10883116
    Abstract: The invention relates to transduction compounds, buffers and methods for introducing molecules into cells. The invention also relates to methods of treatment, pharmaceutical compositions and other uses of the transduction compounds and buffers. The invention also relates to modified cells obtainable by the transduction compounds, buffers and methods of the invention.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: January 5, 2021
    Assignee: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Niels Geijsen, Diego Sebastián D'Astolfo
  • QUINOXALINONE COMPOUNDS, COMPOSITIONS, METHODS, AND KITS FOR INCREASING GENOME EDITING EFFICIENCY
    Publication number: 20200361877
    Abstract: Compounds, methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNA-PK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNA-PK inhibitor disclosed herein.
    Type: Application
    Filed: January 16, 2019
    Publication date: November 19, 2020
    Inventors: Sudipta MAHAJAN, Marc Saul WEINBERG, Diego Sebastian D'ASTOLFO, Kevin M. COTTRELL, Mark A. MORRIS, John Patrick MAXWELL
  • TRANSDUCTION BUFFER
    Publication number: 20160273001
    Abstract: The invention relates to transduction compounds, buffers and methods for introducing molecules into cells. The invention also relates to methods of treatment, pharmaceutical compositions and other uses of the transduction compounds and buffers. The invention also relates to modified cells obtainable by the transduction compounds, buffers and methods of the invention.
    Type: Application
    Filed: August 28, 2014
    Publication date: September 22, 2016
    Applicant: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Niels Geijsen, Diego Sebastián D'Astolfo