Patents by Inventor Diego Tejedor
Diego Tejedor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10851413Abstract: The present invention provides a method for genotyping alleles in at least one homologous genetic loci set, comprising: (i) providing a DNA-containing sample that includes said at least one homologous genetic loci set; (ii) performing PCR amplification of regions of said homologous genetic loci set using consensus sequence-specific primers, wherein said consensus sequence-specific primers bind to consensus sequences that are common to a plurality of genes within the genetic loci set, thereby generating a pool of amplification products; (iii) sequencing a plurality of said amplification products in order to determine the relative proportion of each nucleotide at each position in a sequencing read; (iv) performing a sequence alignment between the sequencing read results of (iii) and at least one reference sequence, which reference sequence corresponds to one of the genes in said homologous genetic loci set; and (v) performing genotype calling of the allele or alleles in said sample based on the relative proportType: GrantFiled: August 12, 2015Date of Patent: December 1, 2020Assignee: Progenika Biopharma S.A.Inventors: Jorge Ochoa, David Arteta, Mariá José Illescas, Monica Lopez, Marianne Stef, Diego Tejedor, Antonio Martìnez
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Patent number: 10253366Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa and RHD*DIVa-2. The method comprises amplifying by PCR a sample obtained from a human subject at intron 3 of the RHD gene locus. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.Type: GrantFiled: April 29, 2016Date of Patent: April 9, 2019Assignee: Progenika Biopharma, S.A.Inventors: Jorge Ochoa, Monica Lopez, Araitz Molano, Diego Tejedor, Antonio Martinez
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Publication number: 20180305756Abstract: The present invention provides a method for genotyping alleles in at least one homologous genetic loci set, comprising: (i) providing a DNA-containing sample that includes said at least one homologous genetic loci set; (ii) performing PCR amplification of regions of said homologous genetic loci set using consensus sequence-specific primers, wherein said consensus sequence-specific primers bind to consensus sequences that are common to a plurality of genes within the genetic loci set, thereby generating a pool of amplification products; (iii) sequencing a plurality of said amplification products in order to determine the relative proportion of each nucleotide at each position in a sequencing read; (iv) performing a sequence alignment between the sequencing read results of (iii) and at least one reference sequence, which reference sequence corresponds to one of the genes in said homologous genetic loci set; and (v) performing genotype calling of the allele or alleles in said sample based on the relative proportType: ApplicationFiled: August 12, 2015Publication date: October 25, 2018Applicant: Progenika Biopharma S.A.Inventors: Jorge Ochoa, David Arteta, Mária José Illescas, Monica Lopez, Marianne Stef, Diego Tejedor, Antonio Martínez
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Patent number: 9637788Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa, RHD*DIVa-2, RHCE*css and RHCE*ce733G. The method comprises genotyping a sample obtained from a human subject at one or more positions in intron 7 of the RHD gene and/or in intron 7 of the RHCE gene. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.Type: GrantFiled: June 14, 2012Date of Patent: May 2, 2017Assignee: Progenika Biopharma, S.A.Inventors: Jorge Ochoa, Monica Lopez, Sergio Escorza, Diego Tejedor, Antonio Martinez, Laureano Simon
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Publication number: 20160244830Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa and RHD*DIVa-2. The method comprises amplifying by PCR a sample obtained from a human subject at intron 3 of the RHD gene locus. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.Type: ApplicationFiled: April 29, 2016Publication date: August 25, 2016Applicant: Progenika Biopharma S.A.Inventors: Jorge Ochoa, Monica Lopez, Araitz Molano, Diego Tejedor, Antonio Martinez
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Patent number: 9359643Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa and RHD*DIVa-2. The method comprises amplifying by PCR a sample obtained from a human subject at intron 3 of the RHD gene locus. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.Type: GrantFiled: March 8, 2013Date of Patent: June 7, 2016Assignee: Progenika Biopharma S.A.Inventors: Jorge Ochoa, Monica Lopez, Araitz Molano, Diego Tejedor, Antonio Martinez
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Publication number: 20160060696Abstract: The invention relates to genotyping and blood cell antigen determination. In particular, the invention addresses discriminating the RHD*DIIIa-CE(4-7)-D or RHD*DIIIa-CE(4-7)-D)-like blood type variants, from RHD*DIIIa, RHD*DIVa-2 and other blood type variants. The invention provides methods for genotyping a subject, comprising determining at least 4 markers in a sample that has been obtained from the subject, wherein the markers comprise: (i) the presence or absence of an RHCE*C allele; (ii) the presence or absence of an RHD/RHCE hybrid exon 3 (RHD/CE Hex03) allele; (iii) the absence of, or a single nucleotide polymorphism (SNP) variant within, any one of position 602 of exon 4, position 667 of exon 5, or position 819 of exon 6 of RHD; and (iv) the absence of, or SNP variant within, position 1048 of RHD exon 7. The invention also provides probes, primers and kits for use in such methods.Type: ApplicationFiled: November 11, 2015Publication date: March 3, 2016Applicant: PROGENIKA BIOPHARMA, S.A.Inventors: Jorge Ochoa, Monica Lopez, Diego Tejedor, Antonio Martinez, Laureano Simon
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Publication number: 20160032386Abstract: A method for predicting the severity or progression of OA in a human subject, comprising: determining the identity of at least one allele at each of at least 4 positions of single nucleotide polymorphism (SNPs) selected from the group consisting of: rs2206593, rs10465850, rs780094, rs1374281, rs1143634, rs2073508, rs2243250, rs4720262, rs917760, rs7838918, rs12009, rs730720, rs874692, rs893953, rs1799750, rs10845493, rs11054704, rs7986347, rs1802536, rs10519263, rs7342880, rs16947882 and rs10413815, and one or more SNPs in linkage disequilibrium at a level of at least R2?0.8 therewith, as well as products, in particular systems and kits for use in such a method.Type: ApplicationFiled: January 30, 2014Publication date: February 4, 2016Applicants: BIOIBERICA, S.A., PROGENIKA BIOPHARMA S.A.Inventors: Josep Escaich, Josep Vergés, Ruth Alonso, Eulàlia Montell, Helena Martínez, Marta Herrero, Francisco Blanco, Antonio Martínez, Diego Tejedor, Marta Artieda, Nerea Bartolomé
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Publication number: 20160010160Abstract: A method for prognosing recurrence of prostate cancer (PCa) in a subject following prostatectomy using the outcomes of selected single nucleotide polymorphisms (SNPs) and clinical variables. A method for genotyping PCa associated genetic variations comprising use of a DNA microarray. A microarray for use in the described methods.Type: ApplicationFiled: July 13, 2015Publication date: January 14, 2016Applicant: PROGENIKA BIOPHARMA, S.A.Inventors: Jokin del Amo, Diego Tejedor Hernandez, Antonio Martinez Martinez, Laureano Simon Buela, Juan Morote Robles
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Publication number: 20150376708Abstract: A method for determining the presence or absence of a genetic segment of interest, such as an exon, an intron or a promoter, in a DNA-containing sample, and probe sets for use in such methods, including probe sets comprising oligonucleotide probes having nucleotides sequences selected from those of SEQ ID NOS: 1-101.Type: ApplicationFiled: September 10, 2015Publication date: December 31, 2015Inventors: David Garcia, Laureano Simon, Antonio Martinez, Jorge Ochoa, Diego Tejedor, Monica Lopez
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Patent number: 9165108Abstract: A method for determining the presence or absence of a genetic segment of interest, such as an exon, an intron or a promoter, in a DNA-containing sample, and probe sets for use in such methods, including probe sets comprising oligonucleotide probes having nucleotides sequences selected from those of SEQ ID NOS: 1-101.Type: GrantFiled: June 16, 2011Date of Patent: October 20, 2015Assignee: Progenika Biopharma, S.A.Inventors: David Garcia, Laureano Simon, Antonio Martinez, Jorge Ochoa, Diego Tejedor, Monica Lopez
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Patent number: 9109257Abstract: A method for prognosing recurrence of prostate cancer (PCa) in a subject following prostatectomy using the outcomes of selected single nucleotide polymorphisms (SNPs) and clinical variables. A method for genotyping PCa associated genetic variations comprising use of a DNA microarray. A microarray for use in the described methods.Type: GrantFiled: July 12, 2007Date of Patent: August 18, 2015Assignee: Progenika Biopharma, S.A.Inventors: Jokin Del Amo, Diego Tejedor Hernández, Antonio Martínez Martínez, Laureano Simón Buela, Juan Morote Robles
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Patent number: 8835111Abstract: The invention relates to methods of evaluating MS severity based on analysis of single nucleotide polymorphisms (SNPs) and to products and kits for use in such methods.Type: GrantFiled: March 12, 2010Date of Patent: September 16, 2014Assignee: Brainco Biopharma S.L.Inventors: David Arteta, Marta Artieda, Diego Tejedor, Antonio Martinez, Laureano Simon, Bart A. Crusius, Salvador Pena, Madeleine Sombekke, Bernard Uitdehaag, Chris Polman
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Publication number: 20140255923Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa and RHD*DIVa-2. The method comprises amplifying by PCR a sample obtained from a human subject at intron 3 of the RHD gene locus. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.Type: ApplicationFiled: March 8, 2013Publication date: September 11, 2014Applicant: PROGENIKA BIOPHARMA S.A.Inventors: Jorge Ochoa, Monica Lopez, Araitz Molano, Diego Tejedor, Antonio Martinez
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Publication number: 20140220567Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa, RHD*DIVa-2, RHCE*css and RHCE*ce733G. The method comprises genotyping a sample obtained from a human subject at one or more positions in intron 7 of the RHD gene and/or in intron 7 of the RHCE gene. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.Type: ApplicationFiled: June 14, 2012Publication date: August 7, 2014Applicant: PROGENIKA BIOPHARMA, S.A.Inventors: Jorge Ochoa, Monica Lopez, Sergio Escorza, Diego Tejedor, Antonio Martinez, Laureano Simon
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Patent number: 8712696Abstract: A method for prognosing a rheumatoid arthritis phenotype using the outcomes of selected single nucleotide polymorphisms (SNPs) and clinical variables. A method for genotyping multiple rheumatoid arthritis associated genetic variations comprising use of a DNA microrarray. A microarray for use in the described methods.Type: GrantFiled: July 12, 2007Date of Patent: April 29, 2014Assignee: Progenika Biopharma, S.A.Inventors: Arrate Eguiara, Diego Tejedor Hernández, Antonio Martínez Martínez, Laureano Simón Buela
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Patent number: 8669049Abstract: The invention relates to extracorporeal methods of analyzing the presence or absence of mutations which cause familial hypercholesterolemia. The inventive methods describe the way in which said mutations can be detected using a DNA sample from an individual and comprising the following: chain reaction of the polymerase with primers which are complementary to the low-density lipoprotein receptor gene; analysis of the amplified product by sequencing; restriction analysis; single strand conformation polymorphism techniques; heteroduplex analysis and analysis of a device on top of a biochip glass support on which oligonucleotide probes are disposed, which can be used to detect the aforementioned mutations in the DNA.Type: GrantFiled: January 21, 2004Date of Patent: March 11, 2014Assignee: Progenika Biopharma, S.A.Inventors: Pedro Mata Lopez, Rodrigo Alberto Alonso Karlezi, Pilar Mozas Alonso, Gilberto Reyes Leal, Miguel Pocovi Mieras, Sergio Castillo Fernandez, Diego Tejedor Hernandez, Antonio Martinez Martinez, Miguel Mallen Perez
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Publication number: 20130263294Abstract: A method for predicting risk of joint dysplasia, osteoarthritis and/or a condition that is secondary to joint dysplasia in a mammalian subject of the order Carnivora, the method comprising: (a) determining the genotype of said subject in respect of one or more genetic polymorphisms and/or alterations, such as polymorphisms in the CHST3 gene; and (b) providing a prediction of said risk based on said genotype. Products for use in such a method and related methods of determining propensity of a subject to respond to therapy and of selective breeding, are also disclosed.Type: ApplicationFiled: September 19, 2011Publication date: October 3, 2013Applicants: BIOIBERICA, S.A., PROGENIKA BIOPHARMA, S.A.Inventors: Antonio Martinez, Laureano Simon, Diego Tejedor, Marta Artieda, Nerea Bartolome, Jose Escaich, Alfonso Velasco, Miriam Selles, Carlos Chetrit, Daniel Martinez, Armand Sanchez, Olga Francino, Elisenda Sanchez
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Patent number: 8296073Abstract: A method for prognosing osteoporosis phenotypes or estimating osteoporosis quantitative traits comprising determining outcomes for selected SNP variables and clinical variables. Products and methods for genotyping multiple osteoporosis associated genetic variations.Type: GrantFiled: July 12, 2007Date of Patent: October 23, 2012Assignees: Progenika Biopharma, S.A., Bioiberica, S.A.Inventors: Ainara Cadaval, Diego Tejedor Hernández, Antonio Martínez Martínez, Laureano Simón Buela
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Publication number: 20120215459Abstract: The invention relates to methods and algorithms for detecting and analysis of copy number variances in a genetic segment. The invention also relates to a computer implemented sequential method of processing and interpreting experimental data generated by genotyping nucleic acid-chips or nucleic acid-beads based on detection of a hybridization signal.Type: ApplicationFiled: September 2, 2010Publication date: August 23, 2012Inventors: Marianne Stef, Diego Tejedor, Antonio Martinez, Laureano Simon