Patents by Inventor Diego Tesauro

Diego Tesauro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUPRAMOLECULAR AGGREGATES CONTAINING AMPHIPHILIC MONOMERS, CHELATING AGENTS AND PEPTIDES FOR USE FOR DRUG DELIVERY AND AS CONTRAST AGENTS
    Publication number: 20140234211
    Abstract: Delivery systems based on liposomes functionalized with peptides and chelating agents, for therapy and imaging by selective targeting of tumour cells expressing the receptors GRP, BB1, BB2, BB3 e BB4 and any other receptor which recognizes the bombesin peptide or analogues thereof are described. In particular, the liposomes contain within them cytotoxic drugs, such as for example doxorubicin, for target-selective antitumour therapy, and, through the presence of the chelating agent, can contain radioactive or paramagnetic ions for the real time visualization of the tumour cells. The liposomes described in this invention thus act as a selective delivery system for drugs and/or contrast agents onto tumour cells expressing the receptors for the class of known peptides such as bombesin (endogenous sequence, analogous or peptidomimetic peptides, agonists or non agonists).
    Type: Application
    Filed: September 28, 2012
    Publication date: August 21, 2014
    Inventors: Antonella Accardo, Diego Tesauro, Giancarlo Morelli, Carlo Pedone, Giuseppe De Rosa, Giuseppina Salzano
  • Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours
    Patent number: 7329644
    Abstract: This patent application describes the preparation of cyclic and branched peptides of general formula (I) and their conjugated derivatives labelled with a paramagnetic or radioactive metal. The compounds of the present invention are used as diagnostic agents to identify and locate primary tumours and their metastases which over-express type A and/or B cholecystokinin receptors, and as therapeutic agents and cholecystokinin agonists or antagonists.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: February 12, 2008
    Assignee: Bracco Imaging S.p.A.
    Inventors: Michele Saviano, Stefania De Luca, Giancarlo Morelli, Diego Tesauro, Carlo Pedone
  • Peptides conjugates, their derivatives with metal complexes and use thereof for magnetic resonance imaging (mri)
    Publication number: 20050008573
    Abstract: The present invention relates to a novel class of contrast agents for use in nuclear magnetic resonance (MRI), to identify and locate primary human tumours and their metastases which over-express type CCK A and/or type B cholecystokinin receptors, and/or type SSTR 1-5 somatostatin receptors.
    Type: Application
    Filed: July 26, 2002
    Publication date: January 13, 2005
    Inventors: Silvio Aime, Eliana Gianolio, Giancarlo Morelli, Carlo Pedone, Diego Tesauro, Luciano Lattuada, Massimo Visigalli, Pier Anelli
  • Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours
    Publication number: 20040254339
    Abstract: This patent application describes the preparation of cyclic and branched peptides of general formula (I) and their conjugated derivatives labelled with a paramagnetic or radioactive metal. The compounds of the present invention are used as diagnostic agents to identify and locate primary tumours and their metastases which over-express type A and/or B cholecystokinin receptors, and as therapeutic agents and cholecystokinin agonists or antagonists.
    Type: Application
    Filed: July 16, 2004
    Publication date: December 16, 2004
    Inventors: Michele Saviano, Stefania De Luca, Giancarlo Morelli, Diego Tesauro, Carlo Pedone