Abstract: The invention relates to the use of acridine or acridine derivatives, preferably in combination with benzalkonium chloride, for the inactivation of enveloped or nonenveloped viruses. The process according to the invention is preferably carried out in the presence of proteins whose biological activity is substantially retained.

Abstract: Methods for growing and neutralizing or removing circoviruses, in particular porcine circoviruses, which are obtained from an infected cell culture after one or more passages in cultures of porcine, bovine or human cells are described. When the porcine circoviruses grow, a cytopathogenic effect occurs in the cell culture. The circoviruses can be neutralized by treatment with an antibody-containing substrate such as porcine serum or human immunoglobulin or be removed by a pasteurization method. Also described are a vaccine and a diagnostic aid containing inactivated or avirulent circoviruses.

Abstract: Methods for growing circoviruses, in particular porcine circoviruses, which are obtained from an infected cell culture after one or more passages in cultures of porcine, bovine or human cells are described. When the porcine circoviruses grow, a cytopathogenic effect occurs in the cell culture.

Abstract: The invention relates to the removal of viruses from aqueous solutions, as a rule protein solutions, by ultrafiltration. This entails the viruses to be removed being increased in size by incubation with a high molecular weight receptor binding thereto, preferably a specific antibody, so that, on the one hand, the separation effect is improved and, on the other hand, a larger pore diameter which can now be chosen for the filters used also makes it possible for smaller viruses to be separated from larger protein molecules present in protein solutions, and, where appropriate, the filtration rate is increased.

Abstract: A process and an agent for the sanitization of tissues or cell cultures and also of materials and equipment which can be contaminated with viruses are described. For sanitization, a solution of a substituted phenol or of a substituted phenol ether is employed here which as substituents carries one or two saturated or unsaturated hydrocarbon radicals which in each case can have up to 4 carbon atoms.

Abstract: The invention relates to the removal of viruses from aqueous solutions, as a rule protein solutions, by ultrafiltration. This entails the viruses to be removed being increased in size by incubation with a high molecular weight receptor binding thereto, preferably a specific antibody, so that, on the one hand, the separation effect is improved and, on the other hand, a larger pore diameter which can now be chosen for the filters used also makes it possible for smaller viruses to be separated from larger protein molecules present in protein solutions, and, where appropriate, the filtration rate is increased.

Abstract: Methods for growing and neutralizing or removing circoviruses, in particular porcine circoviruses, which are obtained from an infected cell culture after one or more passages in cultures of porcine, bovine or human cells are described. When the porcine circoviruses grow, a cytopathogenic effect occurs in the cell culture. The circoviruses can be neutralized by treatment with an antibody-containing substrate such as porcine serum or human immunoglobulin or be removed by a pasteurization method. Also described are a vaccine and a diagnostic aid containing inactivated or avirulent circoviruses.

Abstract: A permanent cell line PH2, and a process for replication of rabies viruses which have a cytopathic effect (CPE) is claimed. The process comprises: infecting the PH2 cell line with the virus to be replicated; incubating the cells; and isolating and purifying virus particles after they have reached a sufficiently high titer.

Abstract: A bovine ovary cell line (FROv), a process for its preparation, and its use for replicating viruses, are described.

Abstract: A solution containing antigen and adjuvant for eliciting an immune response. The adjuvant comprises zinc hydroxide or iron hydroxide in an amount sufficient to enhance the immune response elicited by the antigen. A process for preparation of such a solution is also provided.

Abstract: A process for treating antigen solutions with an adjuvant is described, in which process a zinc hydroxide/calcium hydroxide gel and, where appropriate, additionally a lecithin and, where appropriate, additionally a polyalphaolefin is added to the antigen solution.

Abstract: Iron powder of high compressibility and low bulk density is made by atomizing a stream of molten steel by means of a conical jet of water at a rate in excess of 10 cubic meters water per metric ton of steel, the half cone angle is between 40.degree. and 60.degree., preferably 45.degree.; and air suction is provided in a region upstream from the cone, adjacent to the stream at a pressure of 0.02 to 0.20 bars below ambient, by means of a length adjustable tube extending down from the nozzle chamber. The powder is reduced at 1,000.degree. C. to 1,200.degree. C., and the resulting cake is broken up to obtain a powder having a particle size distribution with a higher content of larger particles than the powder immediately resulting from the atomization.