Patents by Inventor Dieter Bittler

Dieter Bittler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8445469
    Abstract: A 18-Methyl-19-nor-17-pregn-4-ene-21,17-carbolactone of general formula I in which Z, R4, R6, R7 are as defined below with the proviso that the compound is not 18-Methyl-15?,16?-methylene-3-oxo-19-nor-17-pregn-4-ene-21,17-carbolactone.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: May 21, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Rolf Bohlmann, Dieter Bittler, Hermann Kuenzer, Peter Esperling, Hans-Peter Muhn, Karl-Heinrich Fritzemeier, Ulrike Fuhrmann, Katja Prelle, Steffen Borden
  • Publication number: 20090029953
    Abstract: The invention relates to novel 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactones of general formula (I), where Z=O, H2, ?NOR or ?NNHSO2R, where R=H, a straight- or branched-chain 1-4 or 3-4 C alkyl group, R4=H, halogen, methyl or trifluoromethyl, R6 and/or R7 can be ?- or ?-positioned and independently=branched- or straight-chain 1-4 or 3-4 alkyl, or R6=H and R7=a- or ?-positioned, straight- or branched-chain 1-4 or 3-4 C alkyl, or R6 and R7=H, or R6 and R7 together=a- or ?-positioned methylene or an additional bond. The novel compounds have gestagenic and antimineralocorticoid activity and are suitable for the production of pharmaceutical preparations, for example, for oral contraception and the treatment of pre-, peri- and post-menopausal pain.
    Type: Application
    Filed: December 30, 2005
    Publication date: January 29, 2009
    Inventors: Rolf Bohlmann, Dieter Bittler, Hermann Kuenzer, Peter Esperling, Hans Peter Muhn, Karl Heinrich Fritzemeier, Ulrike Fuhrmann, Katja Prelle, Steffen Borden
  • Publication number: 20060252737
    Abstract: This invention describes the new 18-methyl-19-nor-17-pregn-4-ene-21,17-carbolactones of general formula I in which Z means an oxygen atom, two hydrogen atoms, a grouping ?NOR or ?NNHSO2R, whereby R is a hydrogen atom or a straight-chain or branched-chain alkyl group with 1 to 4 or 3 to 4 carbon atoms, R4 is a hydrogen atom, a halogen atom, a methyl group, or a trifluoromethyl group, R6 and/or R7 can be in ?- or ?-position, and, independently of one another, mean a straight-chain or branched-chain alkyl group with 1 to 4 or 3 to 4 carbon atoms, or R6 means a hydrogen atom, and R7 means an ?- or ?-position, straight-chain or branched-chain alkyl group with 1 to 4 or 3 to 4 carbon atoms, or R6 and R7 each mean a hydrogen atom, or R6 and R7 together mean an ?- or ?-position methylene group or an additional bond.
    Type: Application
    Filed: December 30, 2005
    Publication date: November 9, 2006
    Inventors: Rolf Bohlmann, Dieter Bittler, Hermann Kuenzer, Peter Esperling, Hans-Peter Muhn, Karl-Heinrich Fritzemeier, Ulrike Fuhrmann, Katja Prelle, Steffen Borden
  • Patent number: 6288051
    Abstract: This invention describes the new 7&agr;-(5-methylaminopentyl)-estratrienes of general formula I in which R2 stands for a hydrogen or fluorine atom, R17 stands for a hydrogen atom, a methyl or ethinyl group, n stands for 2, 3 or 4, and x stands for 0, 1 or 2. The new compounds are strong, pure antiestrogens and can be used for the production of pharmaceutical agents for treatment of estrogen-dependent diseases, for example, breast cancer, endometrial carcinoma, prostatic hyperplasia, anovulatory infertility and melanoma.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: September 11, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: Dieter Bittler, Rolf Bohlmann, Nikolaus Heinrich, Jorg Kroll, Gerhard Sauer, Yukishige Nishino, Karsten Parczyk, Martin Schneider, Christa Hegelehartung, Rosemarie Lichtner
  • Patent number: 6271403
    Abstract: This invention describes new, substituted 7&agr;-(&egr;-aminoalkyl)-estratrienes of general formula I in which side chain SK is a radical of partial formula The new compounds represent compounds with very strong antiestrogenic action. The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: August 7, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: Rolf Bohlmann, Dieter Bittler, Josef Heindl, Nikolaus Heinrich, Helmut Hofmeister, Hermann K├╝nzer, Gerhard Sauer, Christa Hegele-Hartung, Rosemarie Lichtner, Yukishige Nishino, Karsten Parczyk, Martin Schneider
  • Patent number: 5986115
    Abstract: This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids.The new compounds represent compounds with very strong antiestrogenic action.The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: November 16, 1999
    Assignee: Schering AG
    Inventors: Rolf Bohlmann, Dieter Bittler, Josef Heindl, Nikolaus Heinrich, Helmut Hofmeister, Hermann Kunzer, Gerhard Sauer, Christa Hegele-Hartung, Rosemarie Lichtner, Yukishige Nishino, Karsten Parczyk, Martin Schneider
  • Patent number: 5866560
    Abstract: This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids.The new compounds represent compounds with very strong antiestrogenic action.The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: February 2, 1999
    Assignee: Schering AG
    Inventors: Rolf Bohlmann, Dieter Bittler, Josef Heindl, Nikolaus Heinrich, Helmut Hofmeister, Hermann Kunzer, Gerhard Sauer, Christa Hegele-Hartung, Rosemarie Lichtner, Yukishige Nishino, Karsten Parczyk, Martin Schneider
  • Patent number: 5389624
    Abstract: [3,2-c]Pyrazole and [3,2-d]triazole steroids are useful anti-androgens.
    Type: Grant
    Filed: April 27, 1993
    Date of Patent: February 14, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Hofmeister, Dieter Bittler, Horst Michna, Ursula Habenicht, Karl-Heinrich Fritzemeier, Yukishige Nishino
  • Patent number: 5236912
    Abstract: [3,2-c]Pyrazole and [3,2-d]triazole steroids are useful anti-androgens.
    Type: Grant
    Filed: July 5, 1991
    Date of Patent: August 17, 1993
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Hofmeister, Dieter Bittler, Horst Michna, Ursula Habenicht, Karl-Heinrich Fritzemeier, Yukishige Nishino
  • Patent number: 5010071
    Abstract: Androstane derivatives of the general Formula I ##STR1## in which R.sub.1 represents a hydrogen atom or a methyl group,X and Y each mean hydrogen atoms or together a carbon-carbon bond, andR.sub.2 symbolizes a hydrogen atom or an alkyl group with 1 to 6 carbon atoms,are pharmaceutically effective substances which have a distinct antiandrogenic effectiveness in topical application.
    Type: Grant
    Filed: July 13, 1989
    Date of Patent: April 23, 1991
    Assignee: Schering Aktiengesellschaft
    Inventors: Dieter Bittler, Henry Laurent, Petra Rach, Michael Topert
  • Patent number: 4977147
    Abstract: A pharmaceutical preparation for treating menopausal symptoms, estrogen deficiency and hormone-dependent tumors, and for use as a contraceptive, comprises a compound of formula I ##STR1## wherein R.sub.1 is hydrogen, methyl, a tetrahydropyranyl group or an acyl group andR.sub.2 is hydrogen or methyl.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: December 11, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Peter Jungblut, Rudolf Wiechert, Dieter Bittler
  • Patent number: 4892867
    Abstract: 17.alpha.-Alkyl steroids of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl,R.sub.2 is alkyl or alkenyl of 2-6 carbon atoms,X is oxygen or the grouping H(OR.sub.3) wherein R.sub.3 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, upon topical application, display antiandrogenic properties and can be utilized for the treatment of acne, seborrhea, alopecia and hirsutism.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: January 9, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Rudolf Wiechert, Dieter Bittler, Annerose Schleusener, Manfred Albring
  • Patent number: 4868166
    Abstract: 2,2;6,6-diethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactones of general formula I, ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group,R.sub.2 represents a methyl or ethyl group and ##STR2## process for their production and their pharmaceutical use.
    Type: Grant
    Filed: February 5, 1988
    Date of Patent: September 19, 1989
    Assignee: Schering Aktiengesellschaft
    Inventors: Dieter Bittler, Klaus Nickisch, Henry Laurent, Rudolf Wiechert, Martin Haberey
  • Patent number: 4859659
    Abstract: Dermatics are claimed which are characterized in that they contain as the active compound one or two 17.beta.-methyl-18-nor steroids of general Formula I ##STR1## wherein is a single bond or a double bond,R.sub.1 is a hydrogen atom or a methyl group, andR.sub.2 is an alkyl group of maximally 6 carbon atoms, optionally substituted by an alkanoyloxy group containing 2-6 carbon atoms.
    Type: Grant
    Filed: December 17, 1986
    Date of Patent: August 22, 1989
    Assignee: Schering Aktiengesellschaft
    Inventors: Dieter Bittler, Henry Laurent, Klaus Nickisch, Petra Rach
  • Patent number: 4789668
    Abstract: The disclosure relates to novel 1.alpha.,7.alpha.-dithio-substituted spirolactones of general Formula I ##STR1## wherein R.sup.1 is C.sub.1-3 -alkyl and C.sub.1-3 -acyl andR.sup.2 is hydrogen, C.sub.1-3 -alkyl and C.sub.1-3 -acyl,to their preparation, and to their use as medicinal agents.The compounds of this invention exhibit anti-aldosterone activity and show the profile of effectiveness of a pro-drug.
    Type: Grant
    Filed: October 17, 1986
    Date of Patent: December 6, 1988
    Assignee: Schering Aktiengesellschaft
    Inventors: Klaus Nickisch, Henry Laurent, Dieter Bittler, Rudolf Wiechert, Wolfgang Losert
  • Patent number: 4738957
    Abstract: Estriol esters of Formula I ##STR1## wherein R is, in each case, the residue of an aliphatic monocarboxylic acid of 3-10 carbon atoms,surpass estriol in strength and duration of estrogen activity.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: April 19, 1988
    Assignee: Schering Aktiengesellschaft
    Inventors: Henry Laurent, Dieter Bittler, Sybille Beier, Walter Elger
  • Patent number: 4681875
    Abstract: Estriol esters of Formula I ##STR1## wherein R, in each case, means the residue of a monocarboxylic acid of 2-10 carbon atoms.The novel estriol esters surpass estriol in strength and duration of estrogen effect.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: July 21, 1987
    Assignee: Schering Aktiengesellschaft
    Inventors: Henry Laurent, Dieter Bittler, Sybille Beier, Walter Elger
  • Patent number: 4614616
    Abstract: A process for preparing a 3.beta.,7.beta.-dihydroxy-.DELTA..sup.5 -steroid of the formula ##STR1## wherein Q is ##STR2## and R.sub.1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzylsilyl, comprises fermenting a 3.beta.-hydroxy-.DELTA..sup.5 -steroid of the formula ##STR3## wherein Q is as defined above, andR.sub.2 is hydrogen or alkanoyl of 2-6 carbon atoms, with a culture of Botryodiplodia malorum to obtain the corresponding 3.beta.,7.beta.-dihydroxy-.DELTA..sup.5 -steroid; and, optionally, reacting the resultant product with trimethylacetic anhydride, tert-butyldimethylsilyl chloride, dimethyl-2-(3-methylbutyl)silyl chloride, or tribenzylsilyl chloride.
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: September 30, 1986
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Rudolf Wiechert, Henry Laurent, Klaus Nickisch, Dieter Bittler
  • Patent number: 4587235
    Abstract: Androstane derivatives of Formula I ##STR1## wherein is a single bond or a double bond,R.sub.1 is methyl or ethyl,R.sub.2 is hydrogen or alkyl of 1-8 carbon atoms,--X-- is --(CH.sub.2).sub.n --, --CH.dbd.CH(CH.sub.2).sub.m --, or --C.tbd.C--(CH.sub.2).sub.m -- wherein n is 2 to 6 and m is 1 to 4,--A--B-- is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --CCl.dbd.CH--, ##STR2## --U--V< is --CH.sub.2 --CH<, --CH.dbd.C<, --C(OH).dbd.C<, or --CCl.dbd.C<, and--W--Y-- is --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --C(CH.sub.3).sub.2 --, or ##STR3## with the proviso that the compound is not 17.alpha.-(3-acetoxypropyl)-17.beta.-hydroxy-4,6-androstadien-3-one, are pharmacologically efficacious compounds, e.g., are sebum suppressive.
    Type: Grant
    Filed: June 27, 1984
    Date of Patent: May 6, 1986
    Assignee: Schering Aktiengesellschaft
    Inventors: Dieter Bittler, Henry Laurent, Klaus Nickisch, Rudolf Wiechert
  • Patent number: 4584288
    Abstract: 6,6-ethylene-15,16-methylene-3-oxo-17.alpha.-pregn-4-ene-21,17.alpha.-carbo lactones of general Formula I ##STR1## wherein ##STR2## is a CC-single of CC-double bond, R.sub.1 is a hydrogen atom or a methyl group,R.sub.2 is a methyl or ethyl group, and ##STR3## exhibit strong gestagen potency and an aldosterone-antagonistic activity.
    Type: Grant
    Filed: January 18, 1985
    Date of Patent: April 22, 1986
    Assignee: Schering Aktiengesellschaft
    Inventors: Klaus Nickish, Dieter Bittler, Henry Laurent, Rudolf Wiechert, Sybille Beier, Walter Elger