Patents by Inventor Dieter Dorsch

Dieter Dorsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinolin-2-one derivatives
    Patent number: 11939314
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: March 26, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • QUINOLIN-2-ONE DERIVATIVES
    Publication number: 20230028687
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Application
    Filed: October 12, 2021
    Publication date: January 26, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
  • 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES
    Publication number: 20220267320
    Abstract: Compounds of the formula I are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer. R1 denotes H, Hal, CF3, NO2, A, [C(R3)2]nN(R3)2, [C(R3)2]nHet1, OR3, O[C(R3)2]nN(R3)2, O[C(R3)2]nS(O)mR3, O[C(R3)2]nCOOR3, O[C(R3)2]nCOON(R3)2, O[C(R3)2]nHet1, O[C(R3)2]nN(R3)Het1, O[C(R3)2]nPh, or O[C(R3)2]nCyc. R2 denotes H or CH3. R3 denotes H or A. V denotes H or Hal. X denotes O or N(R3). Y denotes phenylene, pyridin-diyl, thiophen-diyl, 1,3-thiazol-diyl or pyrazol-diyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal and/or A. Z denotes CON(R3)2, phenyl, Het4 or —O-A.
    Type: Application
    Filed: July 22, 2020
    Publication date: August 25, 2022
    Applicant: Merck Patent GmbH
    Inventors: Dieter Dorsch, Andreas Blum, Hans-Peter Buchstaller
  • INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER
    Publication number: 20220127254
    Abstract: Compounds of the formula I are provided. These compounds can inhibit c-Kit kinase and can be employed for the treatment of cancer.
    Type: Application
    Filed: February 10, 2020
    Publication date: April 28, 2022
    Applicant: Merck Patent GmbH
    Inventors: Dieter DORSCH, Andreas Blum
  • Quinolin-2-one derivatives
    Patent number: 11186562
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: November 30, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • Quinolin-2-one derivatives
    Patent number: 11174241
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: November 16, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • QUINOLIN-2-ONE DERIVATIVES
    Publication number: 20200190054
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 18, 2020
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
  • QUINOLIN-2-ONE DERIVATIVES
    Publication number: 20200190055
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 18, 2020
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
  • Quinolin-2-one derivatives
    Patent number: 10669251
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: June 2, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • 1,4-dicarbonyl-piperidyl derivatives
    Patent number: 10570116
    Abstract: Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: February 25, 2020
    Assignee: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Dieter Dorsch
  • Tricyclic heterocylic derivatives
    Patent number: 10570149
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of ATR, and can be employed for the treatment of diseases such as cancer.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: February 25, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Lars Burgdorf, Dieter Dorsch, Christos Tsaklakidis
  • TRICYCLIC HETEROCYLIC DERIVATIVES
    Publication number: 20190300547
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of ATR, and can be employed for the treatment of diseases such as cancer.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 3, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Lars BURGDORF, Dieter DORSCH, Christos TSAKLAKIDIS
  • 1,4-DICARBONYL-PIPERIDYL DERIVATIVES
    Publication number: 20190092751
    Abstract: Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: October 7, 2016
    Publication date: March 28, 2019
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH
  • QUINOLIN-2-ONE DERIVATIVES
    Publication number: 20190023685
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Application
    Filed: December 16, 2016
    Publication date: January 24, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
  • 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives
    Patent number: 10179777
    Abstract: Compounds of the formula I in which W, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of ALK1, AL2 and ALK5, and can be employed for the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: January 15, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Alfred Jonczyk, Mireille Krier
  • 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES
    Publication number: 20180099947
    Abstract: Compounds of the formula I in which W, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of ALK1, AL2 and ALK5, and can be employed for the treatment of diseases such as cancer.
    Type: Application
    Filed: March 22, 2016
    Publication date: April 12, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Alfred JONCZYK, Mireille KRIER
  • Oxoquinazolinyl-butanamide derivatives
    Patent number: 9901577
    Abstract: Compounds of the formula I in which R1-R3 and Z have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: February 27, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Hans-Peter Buchstaller
  • Macrocycles as kinase inhibitors
    Patent number: 9861635
    Abstract: Compounds of the formula I in which X, Y, Q1, M, Q2 and B have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: January 9, 2018
    Assignee: Merck Patent Gmbh
    Inventors: Guenter Hoelzemann, Dieter Dorsch, Ansgar Wegener, Oliver Poeschke, Michael Busch
  • Triazolo[4,5-d]pyrimidine derivatives
    Patent number: 9855268
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: January 2, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Guenter Hoelzemann, Michel Calderini, Ansgar Wegener, Oliver Poeschke
  • Heterocyclyl-butanamide derivatives
    Patent number: 9809598
    Abstract: Compounds of the formula I in which W, X and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: November 7, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Dieter Dorsch